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Effect of Mixer Type on Particle Coating by Magnesium Stearate for Friction and Adhesion Modification
Glidants and lubricants are often used to modify interparticle friction and adhesion in order to improve powder characteristics, such as flowability and compactability. Magnesium stearate (MgSt) powder is widely used as a lubricant. Shear straining causes MgSt particles to break, delaminate, and adh...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400245/ https://www.ncbi.nlm.nih.gov/pubmed/34452172 http://dx.doi.org/10.3390/pharmaceutics13081211 |
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author | Goh, Wei Pin Montoya Sanavia, Ana Ghadiri, Mojtaba |
author_facet | Goh, Wei Pin Montoya Sanavia, Ana Ghadiri, Mojtaba |
author_sort | Goh, Wei Pin |
collection | PubMed |
description | Glidants and lubricants are often used to modify interparticle friction and adhesion in order to improve powder characteristics, such as flowability and compactability. Magnesium stearate (MgSt) powder is widely used as a lubricant. Shear straining causes MgSt particles to break, delaminate, and adhere to the surfaces of the host particles. In this work, a comparison is made of the effect of three mixer types on the lubricating role of MgSt particles. The flow behaviour of α-lactose monohydrate, coated with MgSt at different mass percentages of 0.2, 0.5, 1, and 5 is characterised. The mixing and coating process is carried out by dry blending using Turbula, ProCepT, and Mechanofusion. Measures have been taken to operate under equivalent mixing conditions, as reported in the literature. The flow resistance of the coated samples is measured using the FT4 rheometer. The results indicate that the flow characteristics of the processed powders are remarkably similar in the cases of samples treated by Turbula and Mechanofusion, despite extreme conditions of shear strain rate. The least flow resistance of samples is observed in the case of samples treated by the ProCepT mixer. High-velocity collisions of particles round off the sharp corners and edges, making them less resistant to flow. The optimal percentage of magnesium stearate is found to be approximately 1% by weight for all mixer types, as the addition of higher amounts of lubricant does not further improve the flowability of the material. |
format | Online Article Text |
id | pubmed-8400245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84002452021-08-29 Effect of Mixer Type on Particle Coating by Magnesium Stearate for Friction and Adhesion Modification Goh, Wei Pin Montoya Sanavia, Ana Ghadiri, Mojtaba Pharmaceutics Article Glidants and lubricants are often used to modify interparticle friction and adhesion in order to improve powder characteristics, such as flowability and compactability. Magnesium stearate (MgSt) powder is widely used as a lubricant. Shear straining causes MgSt particles to break, delaminate, and adhere to the surfaces of the host particles. In this work, a comparison is made of the effect of three mixer types on the lubricating role of MgSt particles. The flow behaviour of α-lactose monohydrate, coated with MgSt at different mass percentages of 0.2, 0.5, 1, and 5 is characterised. The mixing and coating process is carried out by dry blending using Turbula, ProCepT, and Mechanofusion. Measures have been taken to operate under equivalent mixing conditions, as reported in the literature. The flow resistance of the coated samples is measured using the FT4 rheometer. The results indicate that the flow characteristics of the processed powders are remarkably similar in the cases of samples treated by Turbula and Mechanofusion, despite extreme conditions of shear strain rate. The least flow resistance of samples is observed in the case of samples treated by the ProCepT mixer. High-velocity collisions of particles round off the sharp corners and edges, making them less resistant to flow. The optimal percentage of magnesium stearate is found to be approximately 1% by weight for all mixer types, as the addition of higher amounts of lubricant does not further improve the flowability of the material. MDPI 2021-08-05 /pmc/articles/PMC8400245/ /pubmed/34452172 http://dx.doi.org/10.3390/pharmaceutics13081211 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Goh, Wei Pin Montoya Sanavia, Ana Ghadiri, Mojtaba Effect of Mixer Type on Particle Coating by Magnesium Stearate for Friction and Adhesion Modification |
title | Effect of Mixer Type on Particle Coating by Magnesium Stearate for Friction and Adhesion Modification |
title_full | Effect of Mixer Type on Particle Coating by Magnesium Stearate for Friction and Adhesion Modification |
title_fullStr | Effect of Mixer Type on Particle Coating by Magnesium Stearate for Friction and Adhesion Modification |
title_full_unstemmed | Effect of Mixer Type on Particle Coating by Magnesium Stearate for Friction and Adhesion Modification |
title_short | Effect of Mixer Type on Particle Coating by Magnesium Stearate for Friction and Adhesion Modification |
title_sort | effect of mixer type on particle coating by magnesium stearate for friction and adhesion modification |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400245/ https://www.ncbi.nlm.nih.gov/pubmed/34452172 http://dx.doi.org/10.3390/pharmaceutics13081211 |
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