Cargando…

Metabolic Changes in SARS-CoV-2 Infection: Clinical Data and Molecular Hypothesis to Explain Alterations of Lipid Profile and Thyroid Function Observed in COVID-19 Patients

It seems that during SARS-CoV-2 infection, total cholesterol, LDL-C, and HDL-C values decrease and lipids could play a fundamental role in viral replication. Moreover, it has been shown that SARS-CoV-2 infection could influence thyroid function. We performed a retrospective analysis of 118 hospitali...

Descripción completa

Detalles Bibliográficos
Autores principales: D’Ardes, Damiano, Rossi, Ilaria, Bucciarelli, Benedetta, Allegra, Marco, Bianco, Francesco, Sinjari, Bruna, Marchioni, Michele, Di Nicola, Marta, Santilli, Francesca, Guagnano, Maria Teresa, Cipollone, Francesco, Bucci, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400261/
https://www.ncbi.nlm.nih.gov/pubmed/34440605
http://dx.doi.org/10.3390/life11080860
_version_ 1783745273798852608
author D’Ardes, Damiano
Rossi, Ilaria
Bucciarelli, Benedetta
Allegra, Marco
Bianco, Francesco
Sinjari, Bruna
Marchioni, Michele
Di Nicola, Marta
Santilli, Francesca
Guagnano, Maria Teresa
Cipollone, Francesco
Bucci, Marco
author_facet D’Ardes, Damiano
Rossi, Ilaria
Bucciarelli, Benedetta
Allegra, Marco
Bianco, Francesco
Sinjari, Bruna
Marchioni, Michele
Di Nicola, Marta
Santilli, Francesca
Guagnano, Maria Teresa
Cipollone, Francesco
Bucci, Marco
author_sort D’Ardes, Damiano
collection PubMed
description It seems that during SARS-CoV-2 infection, total cholesterol, LDL-C, and HDL-C values decrease and lipids could play a fundamental role in viral replication. Moreover, it has been shown that SARS-CoV-2 infection could influence thyroid function. We performed a retrospective analysis of 118 hospitalized patients with COVID-19, comparing pre-infection lipid profile (53 patients) and thyroid-stimulating hormone (TSH) values (45 patients) to those measured on admission. Our aim was to evaluate whether SARS-CoV-2 infection could be involved in thyroid and lipid profile alterations and study possible correlations with disease severity and clinical outcome. Median baseline values at the admission time were: total cholesterol at 136.89 ± 42.73 mg/dL, LDL-C 81.53 ± 30.35 mg/dL, and HDL-C 32.36 ± 15.13 mg/dL; and triglycerides at 115.00 ± 40.45 mg/dL, non-HDL-C 104.53 ± 32.63 md/dL, and TSH 1.15 ± 1.08 μUI/mL. Median values of pre-infection total cholesterol, HDL-C, and TSH were significantly higher than those measured at the admission time (p value < 0.05). The C-reactive protein (CRP) negatively correlated with LDL-C (p = 0.013) and HDL-C (p = 0.05). Our data underline a possible impact of SARS-CoV-2 infection on thyroid function. Moreover it suggests a possible relation between COVID-19 and the lipid profile with a negative correlation between CRP, LDL-C, and HDL-C values, proposing the hypothesis that lipid lowering could follow the rising of the COVID-19 inflammatory state.
format Online
Article
Text
id pubmed-8400261
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84002612021-08-29 Metabolic Changes in SARS-CoV-2 Infection: Clinical Data and Molecular Hypothesis to Explain Alterations of Lipid Profile and Thyroid Function Observed in COVID-19 Patients D’Ardes, Damiano Rossi, Ilaria Bucciarelli, Benedetta Allegra, Marco Bianco, Francesco Sinjari, Bruna Marchioni, Michele Di Nicola, Marta Santilli, Francesca Guagnano, Maria Teresa Cipollone, Francesco Bucci, Marco Life (Basel) Article It seems that during SARS-CoV-2 infection, total cholesterol, LDL-C, and HDL-C values decrease and lipids could play a fundamental role in viral replication. Moreover, it has been shown that SARS-CoV-2 infection could influence thyroid function. We performed a retrospective analysis of 118 hospitalized patients with COVID-19, comparing pre-infection lipid profile (53 patients) and thyroid-stimulating hormone (TSH) values (45 patients) to those measured on admission. Our aim was to evaluate whether SARS-CoV-2 infection could be involved in thyroid and lipid profile alterations and study possible correlations with disease severity and clinical outcome. Median baseline values at the admission time were: total cholesterol at 136.89 ± 42.73 mg/dL, LDL-C 81.53 ± 30.35 mg/dL, and HDL-C 32.36 ± 15.13 mg/dL; and triglycerides at 115.00 ± 40.45 mg/dL, non-HDL-C 104.53 ± 32.63 md/dL, and TSH 1.15 ± 1.08 μUI/mL. Median values of pre-infection total cholesterol, HDL-C, and TSH were significantly higher than those measured at the admission time (p value < 0.05). The C-reactive protein (CRP) negatively correlated with LDL-C (p = 0.013) and HDL-C (p = 0.05). Our data underline a possible impact of SARS-CoV-2 infection on thyroid function. Moreover it suggests a possible relation between COVID-19 and the lipid profile with a negative correlation between CRP, LDL-C, and HDL-C values, proposing the hypothesis that lipid lowering could follow the rising of the COVID-19 inflammatory state. MDPI 2021-08-22 /pmc/articles/PMC8400261/ /pubmed/34440605 http://dx.doi.org/10.3390/life11080860 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
D’Ardes, Damiano
Rossi, Ilaria
Bucciarelli, Benedetta
Allegra, Marco
Bianco, Francesco
Sinjari, Bruna
Marchioni, Michele
Di Nicola, Marta
Santilli, Francesca
Guagnano, Maria Teresa
Cipollone, Francesco
Bucci, Marco
Metabolic Changes in SARS-CoV-2 Infection: Clinical Data and Molecular Hypothesis to Explain Alterations of Lipid Profile and Thyroid Function Observed in COVID-19 Patients
title Metabolic Changes in SARS-CoV-2 Infection: Clinical Data and Molecular Hypothesis to Explain Alterations of Lipid Profile and Thyroid Function Observed in COVID-19 Patients
title_full Metabolic Changes in SARS-CoV-2 Infection: Clinical Data and Molecular Hypothesis to Explain Alterations of Lipid Profile and Thyroid Function Observed in COVID-19 Patients
title_fullStr Metabolic Changes in SARS-CoV-2 Infection: Clinical Data and Molecular Hypothesis to Explain Alterations of Lipid Profile and Thyroid Function Observed in COVID-19 Patients
title_full_unstemmed Metabolic Changes in SARS-CoV-2 Infection: Clinical Data and Molecular Hypothesis to Explain Alterations of Lipid Profile and Thyroid Function Observed in COVID-19 Patients
title_short Metabolic Changes in SARS-CoV-2 Infection: Clinical Data and Molecular Hypothesis to Explain Alterations of Lipid Profile and Thyroid Function Observed in COVID-19 Patients
title_sort metabolic changes in sars-cov-2 infection: clinical data and molecular hypothesis to explain alterations of lipid profile and thyroid function observed in covid-19 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400261/
https://www.ncbi.nlm.nih.gov/pubmed/34440605
http://dx.doi.org/10.3390/life11080860
work_keys_str_mv AT dardesdamiano metabolicchangesinsarscov2infectionclinicaldataandmolecularhypothesistoexplainalterationsoflipidprofileandthyroidfunctionobservedincovid19patients
AT rossiilaria metabolicchangesinsarscov2infectionclinicaldataandmolecularhypothesistoexplainalterationsoflipidprofileandthyroidfunctionobservedincovid19patients
AT bucciarellibenedetta metabolicchangesinsarscov2infectionclinicaldataandmolecularhypothesistoexplainalterationsoflipidprofileandthyroidfunctionobservedincovid19patients
AT allegramarco metabolicchangesinsarscov2infectionclinicaldataandmolecularhypothesistoexplainalterationsoflipidprofileandthyroidfunctionobservedincovid19patients
AT biancofrancesco metabolicchangesinsarscov2infectionclinicaldataandmolecularhypothesistoexplainalterationsoflipidprofileandthyroidfunctionobservedincovid19patients
AT sinjaribruna metabolicchangesinsarscov2infectionclinicaldataandmolecularhypothesistoexplainalterationsoflipidprofileandthyroidfunctionobservedincovid19patients
AT marchionimichele metabolicchangesinsarscov2infectionclinicaldataandmolecularhypothesistoexplainalterationsoflipidprofileandthyroidfunctionobservedincovid19patients
AT dinicolamarta metabolicchangesinsarscov2infectionclinicaldataandmolecularhypothesistoexplainalterationsoflipidprofileandthyroidfunctionobservedincovid19patients
AT santillifrancesca metabolicchangesinsarscov2infectionclinicaldataandmolecularhypothesistoexplainalterationsoflipidprofileandthyroidfunctionobservedincovid19patients
AT guagnanomariateresa metabolicchangesinsarscov2infectionclinicaldataandmolecularhypothesistoexplainalterationsoflipidprofileandthyroidfunctionobservedincovid19patients
AT cipollonefrancesco metabolicchangesinsarscov2infectionclinicaldataandmolecularhypothesistoexplainalterationsoflipidprofileandthyroidfunctionobservedincovid19patients
AT buccimarco metabolicchangesinsarscov2infectionclinicaldataandmolecularhypothesistoexplainalterationsoflipidprofileandthyroidfunctionobservedincovid19patients