Cargando…

Berberine, A Phytoalkaloid, Inhibits Inflammatory Response Induced by LPS through NF-Kappaβ Pathway: Possible Involvement of the IKKα

Berberine (BBR), a plant alkaloid, is known for its therapeutic properties of anticancer, cardioprotective, antidiabetic, hypolipidemic, neuroprotective, and hepatoprotective activities. The present study was to determine the molecular mechanism of BBR’s pharmacological activity in human monocytic (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reddi, Kiran Kumar, Li, Hanxuan, Li, Wei, Tetali, Sarada D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400273/ https://www.ncbi.nlm.nih.gov/pubmed/34443321 http://dx.doi.org/10.3390/molecules26164733

Ejemplares similares

Attribution of NF-κB Activity to CHUK/IKKα-Involved Carcinogenesis
por: Li, Xin, et al.
Publicado: (2021)

GSK-3β controls NF-kappaB activity via IKKγ/NEMO
por: Medunjanin, Senad, et al.
Publicado: (2016)

C26 Cancer-Induced Muscle Wasting Is IKKβ-Dependent and NF-kappaB-Independent
por: Cornwell, Evangeline W., et al.
Publicado: (2014)

An NF-kappaB- and IKK-Independent Function of NEMO Prevents Hepatocarcinogenesis by Suppressing Compensatory Liver Regeneration
por: Koppe, Christiane, et al.
Publicado: (2019)

TfR1 interacts with the IKK complex and is involved in IKK–NF-κB signalling
por: Kenneth, Niall S., et al.
Publicado: (2012)

Marein Prevented LPS-Induced Osteoclastogenesis by Regulating the NF-κB Pathway In Vitro
por: Li, Yuling, et al.
Publicado: (2022)

Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers
por: Anthony, Nahoum G., et al.
Publicado: (2017)

DNA-PK: gatekeeper for IKKγ/NEMO nucleocytoplasmic shuttling in genotoxic stress-induced NF-kappaB activation
por: Medunjanin, Senad, et al.
Publicado: (2020)

IKKα and IKKβ Each Function to Regulate NF-κB Activation in the TNF-Induced/Canonical Pathway
por: Adli, Mazhar, et al.
Publicado: (2010)

Her2 Activates NF-κB and Induces Invasion Through the Canonical Pathway Involving IKKα
por: Merkhofer, Evan C, et al.
Publicado: (2009)

TNFAIP3 interacting protein 2 relieves lipopolysaccharide (LPS)‐induced inflammatory injury in endometritis by inhibiting NF‐kappaB activation
por: Qian, Xinxin, et al.
Publicado: (2023)

Hypothalamic Programming of Systemic Aging Involving IKKβ/NF-κB and GnRH
por: Zhang, Guo, et al.
Publicado: (2013)

Anti-Inflammatory Effects of Berberine Hydrochloride in an LPS-Induced Murine Model of Mastitis
por: Wang, Xichun, et al.
Publicado: (2018)

Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation
por: Olivotto, Eleonora, et al.
Publicado: (2015)

Wnt4 prevents apoptosis and inflammation of dental pulp cells induced by LPS by inhibiting the IKK/NF‑κB pathway
por: Ni, Chengli, et al.
Publicado: (2022)

Effect of berberine on LPS-induced expression of NF-κB/MAPK signalling pathway and related inflammatory cytokines in porcine intestinal epithelial cells
por: Zhu, Zhang, et al.
Publicado: (2020)

IKKα and IKKβ Regulation of DNA Damage-Induced Cleavage of Huntingtin
por: Khoshnan, Ali, et al.
Publicado: (2009)

Curcumin Alleviates Lipopolysaccharide (LPS)-Activated Neuroinflammation via Modulation of miR-199b-5p/IκB Kinase β (IKKβ)/Nuclear Factor Kappa B (NF-κB) Pathway in Microglia
por: Gao, Feng, et al.
Publicado: (2019)

Binding of NF-kappaB p65 subunit to the promoter elements is involved in LPS-induced transactivation of miRNA genes in human biliary epithelial cells
por: Zhou, Rui, et al.
Publicado: (2010)

IKKβ/NF-κB and the miscreant macrophage
por: Timmer, Anjuli M., et al.
Publicado: (2008)

A co-crystal berberine-ibuprofen improves obesity by inhibiting the protein kinases TBK1 and IKKɛ
por: Wang, Man, et al.
Publicado: (2022)

Wedelolactone inhibits LPS-induced pro-inflammation via NF-kappaB Pathway in RAW 264.7 cells
por: Yuan, Fang, et al.
Publicado: (2013)

IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism
por: Bakkar, Nadine, et al.
Publicado: (2012)

NF-kappaB Is Involved in the Regulation of EMT Genes in Breast Cancer Cells
por: Pires, Bruno R. B., et al.
Publicado: (2017)

I-kappa-kinase-2 (IKK-2) inhibition potentiates vincristine cytotoxicity in non-Hodgkin's lymphoma
por: Al-Katib, Ayad, et al.
Publicado: (2010)

IKKα plays a major role in canonical NF-κB signalling in colorectal cells
por: Prescott, Jack A., et al.
Publicado: (2022)

Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancer
por: Nottingham, Liesl K., et al.
Publicado: (2013)

Basal and IL-1β enhanced chondrocyte chemotactic activity on monocytes are co-dependent on both IKKα and IKKβ NF-κB activating kinases
por: Olivotto, Eleonora, et al.
Publicado: (2021)

Inflammatory related gene IKKα, IKKβ, IKKγ cooperates to determine liver cancer stem cells progression by altering telomere via heterochromatin protein 1-HOTAIR axis
por: An, Jiahui, et al.
Publicado: (2016)

Anti-Inflammatory Effects of IKK Inhibitor XII, Thymulin, and Fat-Soluble Antioxidants in LPS-Treated Mice
por: Novoselova, E. G., et al.
Publicado: (2014)

NF-Kappa B Modulation Is Involved in Celastrol Induced Human Multiple Myeloma Cell Apoptosis
por: Ni, Haiwen, et al.
Publicado: (2014)

MicroRNAs modulate the noncanonical NF-κB pathway by regulating IKKα expression during macrophage differentiation
por: Li, Tao, et al.
Publicado: (2010)

NF-kappaB in Lung Tumorigenesis
por: Cai, Zhenjian, et al.
Publicado: (2011)

Modulation of LPS stimulated NF-kappaB mediated Nitric Oxide production by PKCε and JAK2 in RAW macrophages
por: Jones, Edward, et al.
Publicado: (2007)

Inhibition of Osteoblast Functions by IKK/NF-κB in Osteoporosis
por: Chang, Jia, et al.
Publicado: (2009)

NF-KappaB Pathway Is Involved in Bone Marrow Stromal Cell-Produced Pain Relief
por: Guo, Wei, et al.
Publicado: (2018)

JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin
por: Park, Hye Ji, et al.
Publicado: (2008)

Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells
por: Ho, Catherine M. K., et al.
Publicado: (2016)

Structural Basis for the Activation of IKK1/α
por: Polley, Smarajit, et al.
Publicado: (2016)

IKKα Contributes to Canonical NF-κB Activation Downstream of Nod1-Mediated Peptidoglycan Recognition
por: Kim, Man Lyang, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_ok392nf0mi018f9oofetmblfve