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A Prospective Cohort Study of Bioavailable 25-Hydroxyvitamin D Levels as a Marker of Vitamin D Status in Nontuberculous Mycobacterial Pulmonary Disease

Research on vitamin D in patients with nontuberculous mycobacterial (NTM) pulmonary disease (PD) is limited. We aimed to compare the vitamin D parameters of patients with NTM-PD to those of a healthy control group, and to assess the possible predictive markers for a clinical response. We prospective...

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Autores principales: Kwon, Byoung-Soo, Lee, Kyunghoon, Kim, Eun-Sun, Jun, Sun-Hee, Lim, Sung-Yoon, Song, Myung-Jin, Kim, Yeon-Wook, Lee, Yeon-Joo, Park, Jong-Sun, Cho, Young-Jae, Yoon, Ho-Il, Lee, Choon-Taek, Song, Junghan, Lee, Jae-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400277/
https://www.ncbi.nlm.nih.gov/pubmed/34444684
http://dx.doi.org/10.3390/nu13082524
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author Kwon, Byoung-Soo
Lee, Kyunghoon
Kim, Eun-Sun
Jun, Sun-Hee
Lim, Sung-Yoon
Song, Myung-Jin
Kim, Yeon-Wook
Lee, Yeon-Joo
Park, Jong-Sun
Cho, Young-Jae
Yoon, Ho-Il
Lee, Choon-Taek
Song, Junghan
Lee, Jae-Ho
author_facet Kwon, Byoung-Soo
Lee, Kyunghoon
Kim, Eun-Sun
Jun, Sun-Hee
Lim, Sung-Yoon
Song, Myung-Jin
Kim, Yeon-Wook
Lee, Yeon-Joo
Park, Jong-Sun
Cho, Young-Jae
Yoon, Ho-Il
Lee, Choon-Taek
Song, Junghan
Lee, Jae-Ho
author_sort Kwon, Byoung-Soo
collection PubMed
description Research on vitamin D in patients with nontuberculous mycobacterial (NTM) pulmonary disease (PD) is limited. We aimed to compare the vitamin D parameters of patients with NTM-PD to those of a healthy control group, and to assess the possible predictive markers for a clinical response. We prospectively enrolled 53 patients with NTM-PD between January 2014 and December 2016. The clinical data and vitamin D indices, including total, free, bioavailable 25-(OH)D, and vitamin D binding protein (VDBP) genotyping, were measured at baseline and six months after enrollment. An external dataset of 226 healthy controls was compared with the NTM-PD group. The mean age of subjects was 53 years; 54.5% were male. The NTM-PD group was older, predominantly female, and had a lower body mass index (BMI) than the controls. The proportion of patients with vitamin D concentration <50 nmol/L was 52.8% in the NTM-PD group and 54.9% in the control group (p = 0.789). The bioavailable 25-(OH)D concentrations of the NTM-PD group and the controls were similar (6.9 nmol/L vs. 7.6 nmol/L, p = 0.280). In the multivariable analysis, bioavailable 25-(OH)D concentrations were associated with NTM-PD, adjusting for age, sex, BMI, and VDBP levels. Bioavailable 25-(OH)D concentrations were significantly associated with susceptibility to NTM-PD, but not with treatment outcomes. Lower bioavailable 25-(OH)D might be a risk factor for NTM-PD.
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spelling pubmed-84002772021-08-29 A Prospective Cohort Study of Bioavailable 25-Hydroxyvitamin D Levels as a Marker of Vitamin D Status in Nontuberculous Mycobacterial Pulmonary Disease Kwon, Byoung-Soo Lee, Kyunghoon Kim, Eun-Sun Jun, Sun-Hee Lim, Sung-Yoon Song, Myung-Jin Kim, Yeon-Wook Lee, Yeon-Joo Park, Jong-Sun Cho, Young-Jae Yoon, Ho-Il Lee, Choon-Taek Song, Junghan Lee, Jae-Ho Nutrients Article Research on vitamin D in patients with nontuberculous mycobacterial (NTM) pulmonary disease (PD) is limited. We aimed to compare the vitamin D parameters of patients with NTM-PD to those of a healthy control group, and to assess the possible predictive markers for a clinical response. We prospectively enrolled 53 patients with NTM-PD between January 2014 and December 2016. The clinical data and vitamin D indices, including total, free, bioavailable 25-(OH)D, and vitamin D binding protein (VDBP) genotyping, were measured at baseline and six months after enrollment. An external dataset of 226 healthy controls was compared with the NTM-PD group. The mean age of subjects was 53 years; 54.5% were male. The NTM-PD group was older, predominantly female, and had a lower body mass index (BMI) than the controls. The proportion of patients with vitamin D concentration <50 nmol/L was 52.8% in the NTM-PD group and 54.9% in the control group (p = 0.789). The bioavailable 25-(OH)D concentrations of the NTM-PD group and the controls were similar (6.9 nmol/L vs. 7.6 nmol/L, p = 0.280). In the multivariable analysis, bioavailable 25-(OH)D concentrations were associated with NTM-PD, adjusting for age, sex, BMI, and VDBP levels. Bioavailable 25-(OH)D concentrations were significantly associated with susceptibility to NTM-PD, but not with treatment outcomes. Lower bioavailable 25-(OH)D might be a risk factor for NTM-PD. MDPI 2021-07-23 /pmc/articles/PMC8400277/ /pubmed/34444684 http://dx.doi.org/10.3390/nu13082524 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kwon, Byoung-Soo
Lee, Kyunghoon
Kim, Eun-Sun
Jun, Sun-Hee
Lim, Sung-Yoon
Song, Myung-Jin
Kim, Yeon-Wook
Lee, Yeon-Joo
Park, Jong-Sun
Cho, Young-Jae
Yoon, Ho-Il
Lee, Choon-Taek
Song, Junghan
Lee, Jae-Ho
A Prospective Cohort Study of Bioavailable 25-Hydroxyvitamin D Levels as a Marker of Vitamin D Status in Nontuberculous Mycobacterial Pulmonary Disease
title A Prospective Cohort Study of Bioavailable 25-Hydroxyvitamin D Levels as a Marker of Vitamin D Status in Nontuberculous Mycobacterial Pulmonary Disease
title_full A Prospective Cohort Study of Bioavailable 25-Hydroxyvitamin D Levels as a Marker of Vitamin D Status in Nontuberculous Mycobacterial Pulmonary Disease
title_fullStr A Prospective Cohort Study of Bioavailable 25-Hydroxyvitamin D Levels as a Marker of Vitamin D Status in Nontuberculous Mycobacterial Pulmonary Disease
title_full_unstemmed A Prospective Cohort Study of Bioavailable 25-Hydroxyvitamin D Levels as a Marker of Vitamin D Status in Nontuberculous Mycobacterial Pulmonary Disease
title_short A Prospective Cohort Study of Bioavailable 25-Hydroxyvitamin D Levels as a Marker of Vitamin D Status in Nontuberculous Mycobacterial Pulmonary Disease
title_sort prospective cohort study of bioavailable 25-hydroxyvitamin d levels as a marker of vitamin d status in nontuberculous mycobacterial pulmonary disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400277/
https://www.ncbi.nlm.nih.gov/pubmed/34444684
http://dx.doi.org/10.3390/nu13082524
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