Cargando…
A Prospective Cohort Study of Bioavailable 25-Hydroxyvitamin D Levels as a Marker of Vitamin D Status in Nontuberculous Mycobacterial Pulmonary Disease
Research on vitamin D in patients with nontuberculous mycobacterial (NTM) pulmonary disease (PD) is limited. We aimed to compare the vitamin D parameters of patients with NTM-PD to those of a healthy control group, and to assess the possible predictive markers for a clinical response. We prospective...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400277/ https://www.ncbi.nlm.nih.gov/pubmed/34444684 http://dx.doi.org/10.3390/nu13082524 |
_version_ | 1783745277561143296 |
---|---|
author | Kwon, Byoung-Soo Lee, Kyunghoon Kim, Eun-Sun Jun, Sun-Hee Lim, Sung-Yoon Song, Myung-Jin Kim, Yeon-Wook Lee, Yeon-Joo Park, Jong-Sun Cho, Young-Jae Yoon, Ho-Il Lee, Choon-Taek Song, Junghan Lee, Jae-Ho |
author_facet | Kwon, Byoung-Soo Lee, Kyunghoon Kim, Eun-Sun Jun, Sun-Hee Lim, Sung-Yoon Song, Myung-Jin Kim, Yeon-Wook Lee, Yeon-Joo Park, Jong-Sun Cho, Young-Jae Yoon, Ho-Il Lee, Choon-Taek Song, Junghan Lee, Jae-Ho |
author_sort | Kwon, Byoung-Soo |
collection | PubMed |
description | Research on vitamin D in patients with nontuberculous mycobacterial (NTM) pulmonary disease (PD) is limited. We aimed to compare the vitamin D parameters of patients with NTM-PD to those of a healthy control group, and to assess the possible predictive markers for a clinical response. We prospectively enrolled 53 patients with NTM-PD between January 2014 and December 2016. The clinical data and vitamin D indices, including total, free, bioavailable 25-(OH)D, and vitamin D binding protein (VDBP) genotyping, were measured at baseline and six months after enrollment. An external dataset of 226 healthy controls was compared with the NTM-PD group. The mean age of subjects was 53 years; 54.5% were male. The NTM-PD group was older, predominantly female, and had a lower body mass index (BMI) than the controls. The proportion of patients with vitamin D concentration <50 nmol/L was 52.8% in the NTM-PD group and 54.9% in the control group (p = 0.789). The bioavailable 25-(OH)D concentrations of the NTM-PD group and the controls were similar (6.9 nmol/L vs. 7.6 nmol/L, p = 0.280). In the multivariable analysis, bioavailable 25-(OH)D concentrations were associated with NTM-PD, adjusting for age, sex, BMI, and VDBP levels. Bioavailable 25-(OH)D concentrations were significantly associated with susceptibility to NTM-PD, but not with treatment outcomes. Lower bioavailable 25-(OH)D might be a risk factor for NTM-PD. |
format | Online Article Text |
id | pubmed-8400277 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84002772021-08-29 A Prospective Cohort Study of Bioavailable 25-Hydroxyvitamin D Levels as a Marker of Vitamin D Status in Nontuberculous Mycobacterial Pulmonary Disease Kwon, Byoung-Soo Lee, Kyunghoon Kim, Eun-Sun Jun, Sun-Hee Lim, Sung-Yoon Song, Myung-Jin Kim, Yeon-Wook Lee, Yeon-Joo Park, Jong-Sun Cho, Young-Jae Yoon, Ho-Il Lee, Choon-Taek Song, Junghan Lee, Jae-Ho Nutrients Article Research on vitamin D in patients with nontuberculous mycobacterial (NTM) pulmonary disease (PD) is limited. We aimed to compare the vitamin D parameters of patients with NTM-PD to those of a healthy control group, and to assess the possible predictive markers for a clinical response. We prospectively enrolled 53 patients with NTM-PD between January 2014 and December 2016. The clinical data and vitamin D indices, including total, free, bioavailable 25-(OH)D, and vitamin D binding protein (VDBP) genotyping, were measured at baseline and six months after enrollment. An external dataset of 226 healthy controls was compared with the NTM-PD group. The mean age of subjects was 53 years; 54.5% were male. The NTM-PD group was older, predominantly female, and had a lower body mass index (BMI) than the controls. The proportion of patients with vitamin D concentration <50 nmol/L was 52.8% in the NTM-PD group and 54.9% in the control group (p = 0.789). The bioavailable 25-(OH)D concentrations of the NTM-PD group and the controls were similar (6.9 nmol/L vs. 7.6 nmol/L, p = 0.280). In the multivariable analysis, bioavailable 25-(OH)D concentrations were associated with NTM-PD, adjusting for age, sex, BMI, and VDBP levels. Bioavailable 25-(OH)D concentrations were significantly associated with susceptibility to NTM-PD, but not with treatment outcomes. Lower bioavailable 25-(OH)D might be a risk factor for NTM-PD. MDPI 2021-07-23 /pmc/articles/PMC8400277/ /pubmed/34444684 http://dx.doi.org/10.3390/nu13082524 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kwon, Byoung-Soo Lee, Kyunghoon Kim, Eun-Sun Jun, Sun-Hee Lim, Sung-Yoon Song, Myung-Jin Kim, Yeon-Wook Lee, Yeon-Joo Park, Jong-Sun Cho, Young-Jae Yoon, Ho-Il Lee, Choon-Taek Song, Junghan Lee, Jae-Ho A Prospective Cohort Study of Bioavailable 25-Hydroxyvitamin D Levels as a Marker of Vitamin D Status in Nontuberculous Mycobacterial Pulmonary Disease |
title | A Prospective Cohort Study of Bioavailable 25-Hydroxyvitamin D Levels as a Marker of Vitamin D Status in Nontuberculous Mycobacterial Pulmonary Disease |
title_full | A Prospective Cohort Study of Bioavailable 25-Hydroxyvitamin D Levels as a Marker of Vitamin D Status in Nontuberculous Mycobacterial Pulmonary Disease |
title_fullStr | A Prospective Cohort Study of Bioavailable 25-Hydroxyvitamin D Levels as a Marker of Vitamin D Status in Nontuberculous Mycobacterial Pulmonary Disease |
title_full_unstemmed | A Prospective Cohort Study of Bioavailable 25-Hydroxyvitamin D Levels as a Marker of Vitamin D Status in Nontuberculous Mycobacterial Pulmonary Disease |
title_short | A Prospective Cohort Study of Bioavailable 25-Hydroxyvitamin D Levels as a Marker of Vitamin D Status in Nontuberculous Mycobacterial Pulmonary Disease |
title_sort | prospective cohort study of bioavailable 25-hydroxyvitamin d levels as a marker of vitamin d status in nontuberculous mycobacterial pulmonary disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400277/ https://www.ncbi.nlm.nih.gov/pubmed/34444684 http://dx.doi.org/10.3390/nu13082524 |
work_keys_str_mv | AT kwonbyoungsoo aprospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT leekyunghoon aprospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT kimeunsun aprospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT junsunhee aprospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT limsungyoon aprospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT songmyungjin aprospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT kimyeonwook aprospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT leeyeonjoo aprospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT parkjongsun aprospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT choyoungjae aprospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT yoonhoil aprospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT leechoontaek aprospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT songjunghan aprospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT leejaeho aprospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT kwonbyoungsoo prospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT leekyunghoon prospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT kimeunsun prospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT junsunhee prospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT limsungyoon prospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT songmyungjin prospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT kimyeonwook prospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT leeyeonjoo prospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT parkjongsun prospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT choyoungjae prospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT yoonhoil prospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT leechoontaek prospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT songjunghan prospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease AT leejaeho prospectivecohortstudyofbioavailable25hydroxyvitamindlevelsasamarkerofvitamindstatusinnontuberculousmycobacterialpulmonarydisease |