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Palmitoleoylethanolamide Is an Efficient Anti-Obesity Endogenous Compound: Comparison with Oleylethanolamide in Diet-Induced Obesity

Obesity is currently a major epidemic in the developed world. However, we lack a wide range of effective pharmacological treatments and therapies against obesity, and those approved are not devoid of adverse effects. Dietary components such as palmitoleic acid have been proposed to improve metabolic...

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Autores principales: Tovar, Rubén, Gavito, Ana Luisa, Vargas, Antonio, Soverchia, Laura, Hernandez-Folgado, Laura, Jagerovic, Nadine, Baixeras, Elena, Ciccocioppo, Roberto, Rodríguez de Fonseca, Fernando, Decara, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400335/
https://www.ncbi.nlm.nih.gov/pubmed/34444748
http://dx.doi.org/10.3390/nu13082589
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author Tovar, Rubén
Gavito, Ana Luisa
Vargas, Antonio
Soverchia, Laura
Hernandez-Folgado, Laura
Jagerovic, Nadine
Baixeras, Elena
Ciccocioppo, Roberto
Rodríguez de Fonseca, Fernando
Decara, Juan
author_facet Tovar, Rubén
Gavito, Ana Luisa
Vargas, Antonio
Soverchia, Laura
Hernandez-Folgado, Laura
Jagerovic, Nadine
Baixeras, Elena
Ciccocioppo, Roberto
Rodríguez de Fonseca, Fernando
Decara, Juan
author_sort Tovar, Rubén
collection PubMed
description Obesity is currently a major epidemic in the developed world. However, we lack a wide range of effective pharmacological treatments and therapies against obesity, and those approved are not devoid of adverse effects. Dietary components such as palmitoleic acid have been proposed to improve metabolic disbalance in obesity, although the mechanisms involved are not well understood. Both palmitoleic acid (POA) and oleic acid (OA) can be transformed in N-acylethanolamines (NAEs), mediating the effects of dietary POA and OA. To test this hypothesis, here, we study the effects on food intake and body weight gain of palmitoleylethanolamide (POEA) and the OA-derived NAE analogue, oleoylethanolamide (OEA), in Sprague–Dawley rats with a hypercaloric cafeteria diet (HFD). Plasma biochemical metabolites, inflammatory mediators, and lipogenesis-associated liver protein expression were also measured. The results indicate that POEA is able to improve health status in diet-induced obesity, decreasing weight, liver steatosis, inflammation, and dyslipemia. The action of POEA was found to be almost identical to that of OEA, which is an activator of the nuclear peroxisome proliferator receptor alpha (PPARα), and it is structurally related to POEA. These results suggest that the dietary administration of either POA or POEA might be considered as nutritional intervention as complementary treatment for complicated obesity in humans.
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spelling pubmed-84003352021-08-29 Palmitoleoylethanolamide Is an Efficient Anti-Obesity Endogenous Compound: Comparison with Oleylethanolamide in Diet-Induced Obesity Tovar, Rubén Gavito, Ana Luisa Vargas, Antonio Soverchia, Laura Hernandez-Folgado, Laura Jagerovic, Nadine Baixeras, Elena Ciccocioppo, Roberto Rodríguez de Fonseca, Fernando Decara, Juan Nutrients Article Obesity is currently a major epidemic in the developed world. However, we lack a wide range of effective pharmacological treatments and therapies against obesity, and those approved are not devoid of adverse effects. Dietary components such as palmitoleic acid have been proposed to improve metabolic disbalance in obesity, although the mechanisms involved are not well understood. Both palmitoleic acid (POA) and oleic acid (OA) can be transformed in N-acylethanolamines (NAEs), mediating the effects of dietary POA and OA. To test this hypothesis, here, we study the effects on food intake and body weight gain of palmitoleylethanolamide (POEA) and the OA-derived NAE analogue, oleoylethanolamide (OEA), in Sprague–Dawley rats with a hypercaloric cafeteria diet (HFD). Plasma biochemical metabolites, inflammatory mediators, and lipogenesis-associated liver protein expression were also measured. The results indicate that POEA is able to improve health status in diet-induced obesity, decreasing weight, liver steatosis, inflammation, and dyslipemia. The action of POEA was found to be almost identical to that of OEA, which is an activator of the nuclear peroxisome proliferator receptor alpha (PPARα), and it is structurally related to POEA. These results suggest that the dietary administration of either POA or POEA might be considered as nutritional intervention as complementary treatment for complicated obesity in humans. MDPI 2021-07-28 /pmc/articles/PMC8400335/ /pubmed/34444748 http://dx.doi.org/10.3390/nu13082589 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tovar, Rubén
Gavito, Ana Luisa
Vargas, Antonio
Soverchia, Laura
Hernandez-Folgado, Laura
Jagerovic, Nadine
Baixeras, Elena
Ciccocioppo, Roberto
Rodríguez de Fonseca, Fernando
Decara, Juan
Palmitoleoylethanolamide Is an Efficient Anti-Obesity Endogenous Compound: Comparison with Oleylethanolamide in Diet-Induced Obesity
title Palmitoleoylethanolamide Is an Efficient Anti-Obesity Endogenous Compound: Comparison with Oleylethanolamide in Diet-Induced Obesity
title_full Palmitoleoylethanolamide Is an Efficient Anti-Obesity Endogenous Compound: Comparison with Oleylethanolamide in Diet-Induced Obesity
title_fullStr Palmitoleoylethanolamide Is an Efficient Anti-Obesity Endogenous Compound: Comparison with Oleylethanolamide in Diet-Induced Obesity
title_full_unstemmed Palmitoleoylethanolamide Is an Efficient Anti-Obesity Endogenous Compound: Comparison with Oleylethanolamide in Diet-Induced Obesity
title_short Palmitoleoylethanolamide Is an Efficient Anti-Obesity Endogenous Compound: Comparison with Oleylethanolamide in Diet-Induced Obesity
title_sort palmitoleoylethanolamide is an efficient anti-obesity endogenous compound: comparison with oleylethanolamide in diet-induced obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400335/
https://www.ncbi.nlm.nih.gov/pubmed/34444748
http://dx.doi.org/10.3390/nu13082589
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