Abietane Diterpenoids Isolated from Clerodendrum bracteatum and Their Antioxidant and Cytotoxic Activities

Two new abietane diterpenoids (1,2), along with five known diterpenoids (3–7), were first isolated and purified from the stems of Clerodendrum bracteatum. The structures of the new compounds were established by extensive analysis of mass spectrometric and 1-D, 2-D NMR spectroscopic data. Their antio...

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Detalles Bibliográficos
Autores principales: Li, Pingting, Li, Lingling, Zhu, Qin, Xu, Mingfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400359/
https://www.ncbi.nlm.nih.gov/pubmed/34443454
http://dx.doi.org/10.3390/molecules26164870
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author Li, Pingting
Li, Lingling
Zhu, Qin
Xu, Mingfeng
author_facet Li, Pingting
Li, Lingling
Zhu, Qin
Xu, Mingfeng
author_sort Li, Pingting
collection PubMed
description Two new abietane diterpenoids (1,2), along with five known diterpenoids (3–7), were first isolated and purified from the stems of Clerodendrum bracteatum. The structures of the new compounds were established by extensive analysis of mass spectrometric and 1-D, 2-D NMR spectroscopic data. Their antioxidant activities were determined on DPPH radical scavenging and ABTS. The in vitro cytotoxic activities of the compounds were evaluated against the HL-60 and A549 cell lines by the MTT method.
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spelling pubmed-84003592021-08-29 Abietane Diterpenoids Isolated from Clerodendrum bracteatum and Their Antioxidant and Cytotoxic Activities Li, Pingting Li, Lingling Zhu, Qin Xu, Mingfeng Molecules Article Two new abietane diterpenoids (1,2), along with five known diterpenoids (3–7), were first isolated and purified from the stems of Clerodendrum bracteatum. The structures of the new compounds were established by extensive analysis of mass spectrometric and 1-D, 2-D NMR spectroscopic data. Their antioxidant activities were determined on DPPH radical scavenging and ABTS. The in vitro cytotoxic activities of the compounds were evaluated against the HL-60 and A549 cell lines by the MTT method. MDPI 2021-08-11 /pmc/articles/PMC8400359/ /pubmed/34443454 http://dx.doi.org/10.3390/molecules26164870 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Pingting
Li, Lingling
Zhu, Qin
Xu, Mingfeng
Abietane Diterpenoids Isolated from Clerodendrum bracteatum and Their Antioxidant and Cytotoxic Activities
title Abietane Diterpenoids Isolated from Clerodendrum bracteatum and Their Antioxidant and Cytotoxic Activities
title_full Abietane Diterpenoids Isolated from Clerodendrum bracteatum and Their Antioxidant and Cytotoxic Activities
title_fullStr Abietane Diterpenoids Isolated from Clerodendrum bracteatum and Their Antioxidant and Cytotoxic Activities
title_full_unstemmed Abietane Diterpenoids Isolated from Clerodendrum bracteatum and Their Antioxidant and Cytotoxic Activities
title_short Abietane Diterpenoids Isolated from Clerodendrum bracteatum and Their Antioxidant and Cytotoxic Activities
title_sort abietane diterpenoids isolated from clerodendrum bracteatum and their antioxidant and cytotoxic activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400359/
https://www.ncbi.nlm.nih.gov/pubmed/34443454
http://dx.doi.org/10.3390/molecules26164870
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AT zhuqin abietanediterpenoidsisolatedfromclerodendrumbracteatumandtheirantioxidantandcytotoxicactivities
AT xumingfeng abietanediterpenoidsisolatedfromclerodendrumbracteatumandtheirantioxidantandcytotoxicactivities

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