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Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans
The kynurenine pathway of tryptophan (TRP) degradation (KP) generates metabolites with effects on metabolism, immunity, and mental health. Endurance exercise training can change KP metabolites by changing the levels of KP enzymes in skeletal muscle. This leads to a metabolite pattern that favors ene...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400416/ https://www.ncbi.nlm.nih.gov/pubmed/34436450 http://dx.doi.org/10.3390/metabo11080508 |
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author | Valente-Silva, Paula Cervenka, Igor Ferreira, Duarte M. S. Correia, Jorge C. Edman, Sebastian Horwath, Oscar Heng, Benjamin Chow, Sharron Jacobs, Kelly R. Guillemin, Gilles J. Blomstrand, Eva Ruas, Jorge L. |
author_facet | Valente-Silva, Paula Cervenka, Igor Ferreira, Duarte M. S. Correia, Jorge C. Edman, Sebastian Horwath, Oscar Heng, Benjamin Chow, Sharron Jacobs, Kelly R. Guillemin, Gilles J. Blomstrand, Eva Ruas, Jorge L. |
author_sort | Valente-Silva, Paula |
collection | PubMed |
description | The kynurenine pathway of tryptophan (TRP) degradation (KP) generates metabolites with effects on metabolism, immunity, and mental health. Endurance exercise training can change KP metabolites by changing the levels of KP enzymes in skeletal muscle. This leads to a metabolite pattern that favors energy expenditure and an anti-inflammatory immune cell profile and reduces neurotoxic metabolites. Here, we aimed to understand if TRP supplementation in untrained vs. trained subjects affects KP metabolite levels and biological effects. Our data show that chronic TRP supplementation in mice increases all KP metabolites in circulation, and that exercise reduces the neurotoxic branch of the pathway. However, in addition to increasing wheel running, we did not observe other effects of TRP supplementation on training adaptations, energy metabolism or behavior in mice. A similar increase in KP metabolites was seen in trained vs. untrained human volunteers that took a TRP drink while performing a bout of aerobic exercise. With this acute TRP administration, TRP and KYN were higher in the trained vs. the untrained group. Considering the many biological effects of the KP, which can lead to beneficial or deleterious effects to health, our data encourage future studies of the crosstalk between TRP supplementation and physical exercise. |
format | Online Article Text |
id | pubmed-8400416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84004162021-08-29 Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans Valente-Silva, Paula Cervenka, Igor Ferreira, Duarte M. S. Correia, Jorge C. Edman, Sebastian Horwath, Oscar Heng, Benjamin Chow, Sharron Jacobs, Kelly R. Guillemin, Gilles J. Blomstrand, Eva Ruas, Jorge L. Metabolites Article The kynurenine pathway of tryptophan (TRP) degradation (KP) generates metabolites with effects on metabolism, immunity, and mental health. Endurance exercise training can change KP metabolites by changing the levels of KP enzymes in skeletal muscle. This leads to a metabolite pattern that favors energy expenditure and an anti-inflammatory immune cell profile and reduces neurotoxic metabolites. Here, we aimed to understand if TRP supplementation in untrained vs. trained subjects affects KP metabolite levels and biological effects. Our data show that chronic TRP supplementation in mice increases all KP metabolites in circulation, and that exercise reduces the neurotoxic branch of the pathway. However, in addition to increasing wheel running, we did not observe other effects of TRP supplementation on training adaptations, energy metabolism or behavior in mice. A similar increase in KP metabolites was seen in trained vs. untrained human volunteers that took a TRP drink while performing a bout of aerobic exercise. With this acute TRP administration, TRP and KYN were higher in the trained vs. the untrained group. Considering the many biological effects of the KP, which can lead to beneficial or deleterious effects to health, our data encourage future studies of the crosstalk between TRP supplementation and physical exercise. MDPI 2021-08-03 /pmc/articles/PMC8400416/ /pubmed/34436450 http://dx.doi.org/10.3390/metabo11080508 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Valente-Silva, Paula Cervenka, Igor Ferreira, Duarte M. S. Correia, Jorge C. Edman, Sebastian Horwath, Oscar Heng, Benjamin Chow, Sharron Jacobs, Kelly R. Guillemin, Gilles J. Blomstrand, Eva Ruas, Jorge L. Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans |
title | Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans |
title_full | Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans |
title_fullStr | Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans |
title_full_unstemmed | Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans |
title_short | Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans |
title_sort | effects of tryptophan supplementation and exercise on the fate of kynurenine metabolites in mice and humans |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400416/ https://www.ncbi.nlm.nih.gov/pubmed/34436450 http://dx.doi.org/10.3390/metabo11080508 |
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