Cargando…

Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans

The kynurenine pathway of tryptophan (TRP) degradation (KP) generates metabolites with effects on metabolism, immunity, and mental health. Endurance exercise training can change KP metabolites by changing the levels of KP enzymes in skeletal muscle. This leads to a metabolite pattern that favors ene...

Descripción completa

Detalles Bibliográficos
Autores principales: Valente-Silva, Paula, Cervenka, Igor, Ferreira, Duarte M. S., Correia, Jorge C., Edman, Sebastian, Horwath, Oscar, Heng, Benjamin, Chow, Sharron, Jacobs, Kelly R., Guillemin, Gilles J., Blomstrand, Eva, Ruas, Jorge L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400416/
https://www.ncbi.nlm.nih.gov/pubmed/34436450
http://dx.doi.org/10.3390/metabo11080508
_version_ 1783745309821632512
author Valente-Silva, Paula
Cervenka, Igor
Ferreira, Duarte M. S.
Correia, Jorge C.
Edman, Sebastian
Horwath, Oscar
Heng, Benjamin
Chow, Sharron
Jacobs, Kelly R.
Guillemin, Gilles J.
Blomstrand, Eva
Ruas, Jorge L.
author_facet Valente-Silva, Paula
Cervenka, Igor
Ferreira, Duarte M. S.
Correia, Jorge C.
Edman, Sebastian
Horwath, Oscar
Heng, Benjamin
Chow, Sharron
Jacobs, Kelly R.
Guillemin, Gilles J.
Blomstrand, Eva
Ruas, Jorge L.
author_sort Valente-Silva, Paula
collection PubMed
description The kynurenine pathway of tryptophan (TRP) degradation (KP) generates metabolites with effects on metabolism, immunity, and mental health. Endurance exercise training can change KP metabolites by changing the levels of KP enzymes in skeletal muscle. This leads to a metabolite pattern that favors energy expenditure and an anti-inflammatory immune cell profile and reduces neurotoxic metabolites. Here, we aimed to understand if TRP supplementation in untrained vs. trained subjects affects KP metabolite levels and biological effects. Our data show that chronic TRP supplementation in mice increases all KP metabolites in circulation, and that exercise reduces the neurotoxic branch of the pathway. However, in addition to increasing wheel running, we did not observe other effects of TRP supplementation on training adaptations, energy metabolism or behavior in mice. A similar increase in KP metabolites was seen in trained vs. untrained human volunteers that took a TRP drink while performing a bout of aerobic exercise. With this acute TRP administration, TRP and KYN were higher in the trained vs. the untrained group. Considering the many biological effects of the KP, which can lead to beneficial or deleterious effects to health, our data encourage future studies of the crosstalk between TRP supplementation and physical exercise.
format Online
Article
Text
id pubmed-8400416
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84004162021-08-29 Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans Valente-Silva, Paula Cervenka, Igor Ferreira, Duarte M. S. Correia, Jorge C. Edman, Sebastian Horwath, Oscar Heng, Benjamin Chow, Sharron Jacobs, Kelly R. Guillemin, Gilles J. Blomstrand, Eva Ruas, Jorge L. Metabolites Article The kynurenine pathway of tryptophan (TRP) degradation (KP) generates metabolites with effects on metabolism, immunity, and mental health. Endurance exercise training can change KP metabolites by changing the levels of KP enzymes in skeletal muscle. This leads to a metabolite pattern that favors energy expenditure and an anti-inflammatory immune cell profile and reduces neurotoxic metabolites. Here, we aimed to understand if TRP supplementation in untrained vs. trained subjects affects KP metabolite levels and biological effects. Our data show that chronic TRP supplementation in mice increases all KP metabolites in circulation, and that exercise reduces the neurotoxic branch of the pathway. However, in addition to increasing wheel running, we did not observe other effects of TRP supplementation on training adaptations, energy metabolism or behavior in mice. A similar increase in KP metabolites was seen in trained vs. untrained human volunteers that took a TRP drink while performing a bout of aerobic exercise. With this acute TRP administration, TRP and KYN were higher in the trained vs. the untrained group. Considering the many biological effects of the KP, which can lead to beneficial or deleterious effects to health, our data encourage future studies of the crosstalk between TRP supplementation and physical exercise. MDPI 2021-08-03 /pmc/articles/PMC8400416/ /pubmed/34436450 http://dx.doi.org/10.3390/metabo11080508 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Valente-Silva, Paula
Cervenka, Igor
Ferreira, Duarte M. S.
Correia, Jorge C.
Edman, Sebastian
Horwath, Oscar
Heng, Benjamin
Chow, Sharron
Jacobs, Kelly R.
Guillemin, Gilles J.
Blomstrand, Eva
Ruas, Jorge L.
Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans
title Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans
title_full Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans
title_fullStr Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans
title_full_unstemmed Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans
title_short Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans
title_sort effects of tryptophan supplementation and exercise on the fate of kynurenine metabolites in mice and humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400416/
https://www.ncbi.nlm.nih.gov/pubmed/34436450
http://dx.doi.org/10.3390/metabo11080508
work_keys_str_mv AT valentesilvapaula effectsoftryptophansupplementationandexerciseonthefateofkynureninemetabolitesinmiceandhumans
AT cervenkaigor effectsoftryptophansupplementationandexerciseonthefateofkynureninemetabolitesinmiceandhumans
AT ferreiraduartems effectsoftryptophansupplementationandexerciseonthefateofkynureninemetabolitesinmiceandhumans
AT correiajorgec effectsoftryptophansupplementationandexerciseonthefateofkynureninemetabolitesinmiceandhumans
AT edmansebastian effectsoftryptophansupplementationandexerciseonthefateofkynureninemetabolitesinmiceandhumans
AT horwathoscar effectsoftryptophansupplementationandexerciseonthefateofkynureninemetabolitesinmiceandhumans
AT hengbenjamin effectsoftryptophansupplementationandexerciseonthefateofkynureninemetabolitesinmiceandhumans
AT chowsharron effectsoftryptophansupplementationandexerciseonthefateofkynureninemetabolitesinmiceandhumans
AT jacobskellyr effectsoftryptophansupplementationandexerciseonthefateofkynureninemetabolitesinmiceandhumans
AT guillemingillesj effectsoftryptophansupplementationandexerciseonthefateofkynureninemetabolitesinmiceandhumans
AT blomstrandeva effectsoftryptophansupplementationandexerciseonthefateofkynureninemetabolitesinmiceandhumans
AT ruasjorgel effectsoftryptophansupplementationandexerciseonthefateofkynureninemetabolitesinmiceandhumans