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Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review
Intense efforts to develop alternative materials for gelatine as a drug-delivery system are progressing at a high rate. Some of the materials developed are hard capsules made from alginate, carrageenan, hypromellose and cellulose. However, there are still some disadvantages that must be minimised or...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400433/ https://www.ncbi.nlm.nih.gov/pubmed/34451207 http://dx.doi.org/10.3390/polym13162666 |
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author | Fauzi, Muhammad Al Rizqi Dharma Pudjiastuti, Pratiwi Wibowo, Arief Cahyo Hendradi, Esti |
author_facet | Fauzi, Muhammad Al Rizqi Dharma Pudjiastuti, Pratiwi Wibowo, Arief Cahyo Hendradi, Esti |
author_sort | Fauzi, Muhammad Al Rizqi Dharma |
collection | PubMed |
description | Intense efforts to develop alternative materials for gelatine as a drug-delivery system are progressing at a high rate. Some of the materials developed are hard capsules made from alginate, carrageenan, hypromellose and cellulose. However, there are still some disadvantages that must be minimised or eliminated for future use in drug-delivery systems. This review attempts to review the preparation and potential of seaweed-based, specifically carrageenan, hard capsules, summarise their properties and highlight their potential as an optional main component of hard capsules in a drug-delivery system. The characterisation methods reviewed were dimensional analysis, water and ash content, microbial activity, viscosity analysis, mechanical analysis, scanning electron microscopy, swelling degree analysis, gel permeation chromatography, Fourier-transform infrared spectroscopy and thermal analysis. The release kinetics of the capsule is highlighted as well. This review is expected to provide insights for new researchers developing innovative products from carrageenan-based hard capsules, which will support the development goals of the industry. |
format | Online Article Text |
id | pubmed-8400433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84004332021-08-29 Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review Fauzi, Muhammad Al Rizqi Dharma Pudjiastuti, Pratiwi Wibowo, Arief Cahyo Hendradi, Esti Polymers (Basel) Review Intense efforts to develop alternative materials for gelatine as a drug-delivery system are progressing at a high rate. Some of the materials developed are hard capsules made from alginate, carrageenan, hypromellose and cellulose. However, there are still some disadvantages that must be minimised or eliminated for future use in drug-delivery systems. This review attempts to review the preparation and potential of seaweed-based, specifically carrageenan, hard capsules, summarise their properties and highlight their potential as an optional main component of hard capsules in a drug-delivery system. The characterisation methods reviewed were dimensional analysis, water and ash content, microbial activity, viscosity analysis, mechanical analysis, scanning electron microscopy, swelling degree analysis, gel permeation chromatography, Fourier-transform infrared spectroscopy and thermal analysis. The release kinetics of the capsule is highlighted as well. This review is expected to provide insights for new researchers developing innovative products from carrageenan-based hard capsules, which will support the development goals of the industry. MDPI 2021-08-10 /pmc/articles/PMC8400433/ /pubmed/34451207 http://dx.doi.org/10.3390/polym13162666 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fauzi, Muhammad Al Rizqi Dharma Pudjiastuti, Pratiwi Wibowo, Arief Cahyo Hendradi, Esti Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review |
title | Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review |
title_full | Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review |
title_fullStr | Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review |
title_full_unstemmed | Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review |
title_short | Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review |
title_sort | preparation, properties and potential of carrageenan-based hard capsules for replacing gelatine: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400433/ https://www.ncbi.nlm.nih.gov/pubmed/34451207 http://dx.doi.org/10.3390/polym13162666 |
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