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Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review

Intense efforts to develop alternative materials for gelatine as a drug-delivery system are progressing at a high rate. Some of the materials developed are hard capsules made from alginate, carrageenan, hypromellose and cellulose. However, there are still some disadvantages that must be minimised or...

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Autores principales: Fauzi, Muhammad Al Rizqi Dharma, Pudjiastuti, Pratiwi, Wibowo, Arief Cahyo, Hendradi, Esti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400433/
https://www.ncbi.nlm.nih.gov/pubmed/34451207
http://dx.doi.org/10.3390/polym13162666
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author Fauzi, Muhammad Al Rizqi Dharma
Pudjiastuti, Pratiwi
Wibowo, Arief Cahyo
Hendradi, Esti
author_facet Fauzi, Muhammad Al Rizqi Dharma
Pudjiastuti, Pratiwi
Wibowo, Arief Cahyo
Hendradi, Esti
author_sort Fauzi, Muhammad Al Rizqi Dharma
collection PubMed
description Intense efforts to develop alternative materials for gelatine as a drug-delivery system are progressing at a high rate. Some of the materials developed are hard capsules made from alginate, carrageenan, hypromellose and cellulose. However, there are still some disadvantages that must be minimised or eliminated for future use in drug-delivery systems. This review attempts to review the preparation and potential of seaweed-based, specifically carrageenan, hard capsules, summarise their properties and highlight their potential as an optional main component of hard capsules in a drug-delivery system. The characterisation methods reviewed were dimensional analysis, water and ash content, microbial activity, viscosity analysis, mechanical analysis, scanning electron microscopy, swelling degree analysis, gel permeation chromatography, Fourier-transform infrared spectroscopy and thermal analysis. The release kinetics of the capsule is highlighted as well. This review is expected to provide insights for new researchers developing innovative products from carrageenan-based hard capsules, which will support the development goals of the industry.
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spelling pubmed-84004332021-08-29 Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review Fauzi, Muhammad Al Rizqi Dharma Pudjiastuti, Pratiwi Wibowo, Arief Cahyo Hendradi, Esti Polymers (Basel) Review Intense efforts to develop alternative materials for gelatine as a drug-delivery system are progressing at a high rate. Some of the materials developed are hard capsules made from alginate, carrageenan, hypromellose and cellulose. However, there are still some disadvantages that must be minimised or eliminated for future use in drug-delivery systems. This review attempts to review the preparation and potential of seaweed-based, specifically carrageenan, hard capsules, summarise their properties and highlight their potential as an optional main component of hard capsules in a drug-delivery system. The characterisation methods reviewed were dimensional analysis, water and ash content, microbial activity, viscosity analysis, mechanical analysis, scanning electron microscopy, swelling degree analysis, gel permeation chromatography, Fourier-transform infrared spectroscopy and thermal analysis. The release kinetics of the capsule is highlighted as well. This review is expected to provide insights for new researchers developing innovative products from carrageenan-based hard capsules, which will support the development goals of the industry. MDPI 2021-08-10 /pmc/articles/PMC8400433/ /pubmed/34451207 http://dx.doi.org/10.3390/polym13162666 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fauzi, Muhammad Al Rizqi Dharma
Pudjiastuti, Pratiwi
Wibowo, Arief Cahyo
Hendradi, Esti
Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review
title Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review
title_full Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review
title_fullStr Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review
title_full_unstemmed Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review
title_short Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review
title_sort preparation, properties and potential of carrageenan-based hard capsules for replacing gelatine: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400433/
https://www.ncbi.nlm.nih.gov/pubmed/34451207
http://dx.doi.org/10.3390/polym13162666
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