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Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge Theonella sp.: Moving from Correlation toward Causation
Marine sponges have been recognized as a rich source of potential anti-proliferative metabolites. Currently, there are two sponge-derived anti-cancer agents (a macrolide and a nucleoside) isolated from the Porifera phylum, suggesting the great potential of this sponge as a rich source for anti-neopl...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400523/ https://www.ncbi.nlm.nih.gov/pubmed/34436473 http://dx.doi.org/10.3390/metabo11080532 |
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author | Lai, Kuei-Hung Peng, Bo-Rong Su, Chun-Han El-Shazly, Mohamed Sun, Yi-Long Shih, Ming-Cheng Huang, Yu-Ting Yen, Pei-Tzu Wang, Lung-Shuo Su, Jui-Hsin |
author_facet | Lai, Kuei-Hung Peng, Bo-Rong Su, Chun-Han El-Shazly, Mohamed Sun, Yi-Long Shih, Ming-Cheng Huang, Yu-Ting Yen, Pei-Tzu Wang, Lung-Shuo Su, Jui-Hsin |
author_sort | Lai, Kuei-Hung |
collection | PubMed |
description | Marine sponges have been recognized as a rich source of potential anti-proliferative metabolites. Currently, there are two sponge-derived anti-cancer agents (a macrolide and a nucleoside) isolated from the Porifera phylum, suggesting the great potential of this sponge as a rich source for anti-neoplastic agents. To search for more bioactive metabolites from this phylum, we examined the EtOAc extract of Theonella sp. sponge. We isolated seven compounds (1–7), including four 4-methylene sterols (1–4), two nucleosides (5 and 6), and one macrolide (7). Among them, theonellasterol L (1) was identified for the first time, while 5′-O-acetyl-2′-deoxyuridine (5) and 5′-O-acetylthymidine (6) were the first identified deoxyuridine and thymidine derivatives from the sponge Theonella sp. These structures were elucidated based on their spectroscopic data. The anti-proliferation activity of compounds 1–7 against the MCF-7, MDA-MB-231, T-47D, HCT-116, DLD-1, K562, and Molt 4 cancer cell lines was determined. The results indicated that the 14-/15-oxygenated moiety played an important role in the antiproliferative activity and the macrolide derivatives dominated the anti-proliferative effect of the sponge Theonella sp. The in silico analysis, using a chemical global positioning system for natural products (ChemGPS-NP), indicated an anti-proliferative mode of actions (MOA) suggesting the potential applications of the isolated active metabolites as anti-proliferative agents. |
format | Online Article Text |
id | pubmed-8400523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84005232021-08-29 Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge Theonella sp.: Moving from Correlation toward Causation Lai, Kuei-Hung Peng, Bo-Rong Su, Chun-Han El-Shazly, Mohamed Sun, Yi-Long Shih, Ming-Cheng Huang, Yu-Ting Yen, Pei-Tzu Wang, Lung-Shuo Su, Jui-Hsin Metabolites Article Marine sponges have been recognized as a rich source of potential anti-proliferative metabolites. Currently, there are two sponge-derived anti-cancer agents (a macrolide and a nucleoside) isolated from the Porifera phylum, suggesting the great potential of this sponge as a rich source for anti-neoplastic agents. To search for more bioactive metabolites from this phylum, we examined the EtOAc extract of Theonella sp. sponge. We isolated seven compounds (1–7), including four 4-methylene sterols (1–4), two nucleosides (5 and 6), and one macrolide (7). Among them, theonellasterol L (1) was identified for the first time, while 5′-O-acetyl-2′-deoxyuridine (5) and 5′-O-acetylthymidine (6) were the first identified deoxyuridine and thymidine derivatives from the sponge Theonella sp. These structures were elucidated based on their spectroscopic data. The anti-proliferation activity of compounds 1–7 against the MCF-7, MDA-MB-231, T-47D, HCT-116, DLD-1, K562, and Molt 4 cancer cell lines was determined. The results indicated that the 14-/15-oxygenated moiety played an important role in the antiproliferative activity and the macrolide derivatives dominated the anti-proliferative effect of the sponge Theonella sp. The in silico analysis, using a chemical global positioning system for natural products (ChemGPS-NP), indicated an anti-proliferative mode of actions (MOA) suggesting the potential applications of the isolated active metabolites as anti-proliferative agents. MDPI 2021-08-10 /pmc/articles/PMC8400523/ /pubmed/34436473 http://dx.doi.org/10.3390/metabo11080532 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lai, Kuei-Hung Peng, Bo-Rong Su, Chun-Han El-Shazly, Mohamed Sun, Yi-Long Shih, Ming-Cheng Huang, Yu-Ting Yen, Pei-Tzu Wang, Lung-Shuo Su, Jui-Hsin Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge Theonella sp.: Moving from Correlation toward Causation |
title | Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge Theonella sp.: Moving from Correlation toward Causation |
title_full | Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge Theonella sp.: Moving from Correlation toward Causation |
title_fullStr | Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge Theonella sp.: Moving from Correlation toward Causation |
title_full_unstemmed | Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge Theonella sp.: Moving from Correlation toward Causation |
title_short | Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge Theonella sp.: Moving from Correlation toward Causation |
title_sort | anti-proliferative potential of secondary metabolites from the marine sponge theonella sp.: moving from correlation toward causation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400523/ https://www.ncbi.nlm.nih.gov/pubmed/34436473 http://dx.doi.org/10.3390/metabo11080532 |
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