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Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge Theonella sp.: Moving from Correlation toward Causation

Marine sponges have been recognized as a rich source of potential anti-proliferative metabolites. Currently, there are two sponge-derived anti-cancer agents (a macrolide and a nucleoside) isolated from the Porifera phylum, suggesting the great potential of this sponge as a rich source for anti-neopl...

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Autores principales: Lai, Kuei-Hung, Peng, Bo-Rong, Su, Chun-Han, El-Shazly, Mohamed, Sun, Yi-Long, Shih, Ming-Cheng, Huang, Yu-Ting, Yen, Pei-Tzu, Wang, Lung-Shuo, Su, Jui-Hsin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400523/
https://www.ncbi.nlm.nih.gov/pubmed/34436473
http://dx.doi.org/10.3390/metabo11080532
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author Lai, Kuei-Hung
Peng, Bo-Rong
Su, Chun-Han
El-Shazly, Mohamed
Sun, Yi-Long
Shih, Ming-Cheng
Huang, Yu-Ting
Yen, Pei-Tzu
Wang, Lung-Shuo
Su, Jui-Hsin
author_facet Lai, Kuei-Hung
Peng, Bo-Rong
Su, Chun-Han
El-Shazly, Mohamed
Sun, Yi-Long
Shih, Ming-Cheng
Huang, Yu-Ting
Yen, Pei-Tzu
Wang, Lung-Shuo
Su, Jui-Hsin
author_sort Lai, Kuei-Hung
collection PubMed
description Marine sponges have been recognized as a rich source of potential anti-proliferative metabolites. Currently, there are two sponge-derived anti-cancer agents (a macrolide and a nucleoside) isolated from the Porifera phylum, suggesting the great potential of this sponge as a rich source for anti-neoplastic agents. To search for more bioactive metabolites from this phylum, we examined the EtOAc extract of Theonella sp. sponge. We isolated seven compounds (1–7), including four 4-methylene sterols (1–4), two nucleosides (5 and 6), and one macrolide (7). Among them, theonellasterol L (1) was identified for the first time, while 5′-O-acetyl-2′-deoxyuridine (5) and 5′-O-acetylthymidine (6) were the first identified deoxyuridine and thymidine derivatives from the sponge Theonella sp. These structures were elucidated based on their spectroscopic data. The anti-proliferation activity of compounds 1–7 against the MCF-7, MDA-MB-231, T-47D, HCT-116, DLD-1, K562, and Molt 4 cancer cell lines was determined. The results indicated that the 14-/15-oxygenated moiety played an important role in the antiproliferative activity and the macrolide derivatives dominated the anti-proliferative effect of the sponge Theonella sp. The in silico analysis, using a chemical global positioning system for natural products (ChemGPS-NP), indicated an anti-proliferative mode of actions (MOA) suggesting the potential applications of the isolated active metabolites as anti-proliferative agents.
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spelling pubmed-84005232021-08-29 Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge Theonella sp.: Moving from Correlation toward Causation Lai, Kuei-Hung Peng, Bo-Rong Su, Chun-Han El-Shazly, Mohamed Sun, Yi-Long Shih, Ming-Cheng Huang, Yu-Ting Yen, Pei-Tzu Wang, Lung-Shuo Su, Jui-Hsin Metabolites Article Marine sponges have been recognized as a rich source of potential anti-proliferative metabolites. Currently, there are two sponge-derived anti-cancer agents (a macrolide and a nucleoside) isolated from the Porifera phylum, suggesting the great potential of this sponge as a rich source for anti-neoplastic agents. To search for more bioactive metabolites from this phylum, we examined the EtOAc extract of Theonella sp. sponge. We isolated seven compounds (1–7), including four 4-methylene sterols (1–4), two nucleosides (5 and 6), and one macrolide (7). Among them, theonellasterol L (1) was identified for the first time, while 5′-O-acetyl-2′-deoxyuridine (5) and 5′-O-acetylthymidine (6) were the first identified deoxyuridine and thymidine derivatives from the sponge Theonella sp. These structures were elucidated based on their spectroscopic data. The anti-proliferation activity of compounds 1–7 against the MCF-7, MDA-MB-231, T-47D, HCT-116, DLD-1, K562, and Molt 4 cancer cell lines was determined. The results indicated that the 14-/15-oxygenated moiety played an important role in the antiproliferative activity and the macrolide derivatives dominated the anti-proliferative effect of the sponge Theonella sp. The in silico analysis, using a chemical global positioning system for natural products (ChemGPS-NP), indicated an anti-proliferative mode of actions (MOA) suggesting the potential applications of the isolated active metabolites as anti-proliferative agents. MDPI 2021-08-10 /pmc/articles/PMC8400523/ /pubmed/34436473 http://dx.doi.org/10.3390/metabo11080532 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lai, Kuei-Hung
Peng, Bo-Rong
Su, Chun-Han
El-Shazly, Mohamed
Sun, Yi-Long
Shih, Ming-Cheng
Huang, Yu-Ting
Yen, Pei-Tzu
Wang, Lung-Shuo
Su, Jui-Hsin
Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge Theonella sp.: Moving from Correlation toward Causation
title Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge Theonella sp.: Moving from Correlation toward Causation
title_full Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge Theonella sp.: Moving from Correlation toward Causation
title_fullStr Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge Theonella sp.: Moving from Correlation toward Causation
title_full_unstemmed Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge Theonella sp.: Moving from Correlation toward Causation
title_short Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge Theonella sp.: Moving from Correlation toward Causation
title_sort anti-proliferative potential of secondary metabolites from the marine sponge theonella sp.: moving from correlation toward causation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400523/
https://www.ncbi.nlm.nih.gov/pubmed/34436473
http://dx.doi.org/10.3390/metabo11080532
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