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Extensive Study of Breast Milk and Infant Growth: Protocol of the Cambridge Baby Growth and Breastfeeding Study (CBGS-BF)

Growth and nutrition during early life have been strongly linked to future health and metabolic risks. The Cambridge Baby Growth Study (CBGS), a longitudinal birth cohort of 2229 mother–infant pairs, was set up in 2001 to investigate early life determinant factors of infant growth and body compositi...

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Autores principales: Olga, Laurentya, Petry, Clive J., van Diepen, Janna A., Prentice, Philippa M., Hughes, Ieuan A., Vervoort, Jacques, Boekhorst, Jos, Chichlowski, Maciej, Gross, Gabriele, Dunger, David B., Ong, Ken K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400677/
https://www.ncbi.nlm.nih.gov/pubmed/34445039
http://dx.doi.org/10.3390/nu13082879
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author Olga, Laurentya
Petry, Clive J.
van Diepen, Janna A.
Prentice, Philippa M.
Hughes, Ieuan A.
Vervoort, Jacques
Boekhorst, Jos
Chichlowski, Maciej
Gross, Gabriele
Dunger, David B.
Ong, Ken K.
author_facet Olga, Laurentya
Petry, Clive J.
van Diepen, Janna A.
Prentice, Philippa M.
Hughes, Ieuan A.
Vervoort, Jacques
Boekhorst, Jos
Chichlowski, Maciej
Gross, Gabriele
Dunger, David B.
Ong, Ken K.
author_sort Olga, Laurentya
collection PubMed
description Growth and nutrition during early life have been strongly linked to future health and metabolic risks. The Cambridge Baby Growth Study (CBGS), a longitudinal birth cohort of 2229 mother–infant pairs, was set up in 2001 to investigate early life determinant factors of infant growth and body composition in the UK setting. To carry out extensive profiling of breastmilk intakes and composition in relation to infancy growth, the Cambridge Baby Growth and Breastfeeding Study (CBGS-BF) was established upon the original CBGS. The strict inclusion criteria were applied, focusing on a normal birth weight vaginally delivered infant cohort born of healthy and non-obese mothers. Crucially, only infants who were exclusively breastfed for the first 6 weeks of life were retained in the analysed study sample. At each visit from birth, 2 weeks, 6 weeks, and then at 3, 6, 12, 24, and 36 months, longitudinal anthropometric measurements and blood spot collections were conducted. Infant body composition was assessed using air displacement plethysmography (ADP) at 6 weeks and 3 months of age. Breast milk was collected for macronutrients and human milk oligosaccharides (HMO) measurements. Breast milk intake volume was also estimated, as well as sterile breastmilk and infant stool collection for microbiome study.
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spelling pubmed-84006772021-08-29 Extensive Study of Breast Milk and Infant Growth: Protocol of the Cambridge Baby Growth and Breastfeeding Study (CBGS-BF) Olga, Laurentya Petry, Clive J. van Diepen, Janna A. Prentice, Philippa M. Hughes, Ieuan A. Vervoort, Jacques Boekhorst, Jos Chichlowski, Maciej Gross, Gabriele Dunger, David B. Ong, Ken K. Nutrients Article Growth and nutrition during early life have been strongly linked to future health and metabolic risks. The Cambridge Baby Growth Study (CBGS), a longitudinal birth cohort of 2229 mother–infant pairs, was set up in 2001 to investigate early life determinant factors of infant growth and body composition in the UK setting. To carry out extensive profiling of breastmilk intakes and composition in relation to infancy growth, the Cambridge Baby Growth and Breastfeeding Study (CBGS-BF) was established upon the original CBGS. The strict inclusion criteria were applied, focusing on a normal birth weight vaginally delivered infant cohort born of healthy and non-obese mothers. Crucially, only infants who were exclusively breastfed for the first 6 weeks of life were retained in the analysed study sample. At each visit from birth, 2 weeks, 6 weeks, and then at 3, 6, 12, 24, and 36 months, longitudinal anthropometric measurements and blood spot collections were conducted. Infant body composition was assessed using air displacement plethysmography (ADP) at 6 weeks and 3 months of age. Breast milk was collected for macronutrients and human milk oligosaccharides (HMO) measurements. Breast milk intake volume was also estimated, as well as sterile breastmilk and infant stool collection for microbiome study. MDPI 2021-08-21 /pmc/articles/PMC8400677/ /pubmed/34445039 http://dx.doi.org/10.3390/nu13082879 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Olga, Laurentya
Petry, Clive J.
van Diepen, Janna A.
Prentice, Philippa M.
Hughes, Ieuan A.
Vervoort, Jacques
Boekhorst, Jos
Chichlowski, Maciej
Gross, Gabriele
Dunger, David B.
Ong, Ken K.
Extensive Study of Breast Milk and Infant Growth: Protocol of the Cambridge Baby Growth and Breastfeeding Study (CBGS-BF)
title Extensive Study of Breast Milk and Infant Growth: Protocol of the Cambridge Baby Growth and Breastfeeding Study (CBGS-BF)
title_full Extensive Study of Breast Milk and Infant Growth: Protocol of the Cambridge Baby Growth and Breastfeeding Study (CBGS-BF)
title_fullStr Extensive Study of Breast Milk and Infant Growth: Protocol of the Cambridge Baby Growth and Breastfeeding Study (CBGS-BF)
title_full_unstemmed Extensive Study of Breast Milk and Infant Growth: Protocol of the Cambridge Baby Growth and Breastfeeding Study (CBGS-BF)
title_short Extensive Study of Breast Milk and Infant Growth: Protocol of the Cambridge Baby Growth and Breastfeeding Study (CBGS-BF)
title_sort extensive study of breast milk and infant growth: protocol of the cambridge baby growth and breastfeeding study (cbgs-bf)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400677/
https://www.ncbi.nlm.nih.gov/pubmed/34445039
http://dx.doi.org/10.3390/nu13082879
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