Cargando…

A Fully Human Monoclonal Antibody Targeting cKIT Is a Potent Inhibitor of Pathological Choroidal Neovascularization in Mice

Stem cell factor (SCF) and its receptor, cKIT, are novel regulators of pathological neovascularization in the eye, which suggests that inhibition of SCF/cKIT signaling may be a novel pharmacological strategy for treating neovascular age-related macular degeneration (AMD). This study evaluated the th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Seo, Songyi, Kim, Koung Li, Yeo, Yeongju, Kim, Ryul-I, Jeong, Hayoung, Kim, Jin-Ock, Song, Sun-Hwa, An, Mi-Jin, Kim, Jung-Woong, Hong, Hye Kyoung, Ham, Min Hee, Woo, Se Joon, Sung, Jong-Hyuk, Park, Sang Gyu, Suh, Wonhee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400730/ https://www.ncbi.nlm.nih.gov/pubmed/34452268 http://dx.doi.org/10.3390/pharmaceutics13081308

Ejemplares similares

Evogliptin, a dipeptidyl peptidase-4 inhibitor, attenuates pathological retinal angiogenesis by suppressing vascular endothelial growth factor-induced Arf6 activation
por: Seo, Songyi, et al.
Publicado: (2020)

Crosstalk between BMP signaling and KCNK3 in phenotypic switching of pulmonary vascular smooth muscle cells
por: Yeo, Yeongju, et al.
Publicado: (2022)

A fully human anti-c-Kit monoclonal antibody 2G4 inhibits proliferation and degranulation of human mast cells
por: Kim, Kwang-Hyeok, et al.
Publicado: (2022)

Apatinib-loaded nanoparticles suppress vascular endothelial growth factor-induced angiogenesis and experimental corneal neovascularization
por: Lee, Jung Eun, et al.
Publicado: (2017)

Antiangiogenic effect of dasatinib in murine models of oxygen-induced retinopathy and laser-induced choroidal neovascularization
por: Seo, Songyi, et al.
Publicado: (2017)

Sustained-Release Microspheres of Rivoceranib for the Treatment of Subfoveal Choroidal Neovascularization
por: Kim, E Seul, et al.
Publicado: (2021)

Lnk-dependent axis of SCF–cKit signal for osteogenesis in bone fracture healing
por: Matsumoto, Tomoyuki, et al.
Publicado: (2010)

Phosphoproteomic Landscaping Identifies Non-canonical cKIT Signaling in Polycythemia Vera Erythroid Progenitors
por: Federici, Giulia, et al.
Publicado: (2019)

Microenvironment-Induced Non-sporadic Expression of the AXL and cKIT Receptors Are Related to Epithelial Plasticity and Drug Resistance
por: Jokela, Tiina A., et al.
Publicado: (2018)

Progressing Vulvar Melanoma Caused by Instability in cKIT Juxtamembrane Domain: A Case Report and Review of Literature
por: Englert-Golon, Monika, et al.
Publicado: (2022)

Risk Factors and Outcomes of Choroidal Neovascularization Secondary to Central Serous Chorioretinopathy
por: Lee, Ga-In, et al.
Publicado: (2019)

Axitinib overcomes multiple imatinib resistant cKIT mutations including the gatekeeper mutation T670I in gastrointestinal stromal tumors
por: Liu, Feiyang, et al.
Publicado: (2019)

The effect of intravitreal brolucizumab on choroidal thickness in patients with neovascular age-related macular degeneration
por: Bae, Ki Woong, et al.
Publicado: (2022)

Inhibition of choroidal neovascularization by homoisoflavanone, a new angiogenesis inhibitor
por: Kim, Jeong Hun, et al.
Publicado: (2008)

Swept-Source Optical Coherence Tomography Angiography According to the Type of Choroidal Neovascularization
por: Yeo, Joon Hyung, et al.
Publicado: (2019)

Human CD117 (cKit)+ Innate Lymphoid Cells Have a Discrete Transcriptional Profile at Homeostasis and Are Expanded during Filarial Infection
por: Boyd, Alexis, et al.
Publicado: (2014)

Inhibition of choroidal neovascularization by anti-EphB4 monoclonal antibody
por: SU, DONGFENG, et al.
Publicado: (2013)

A Case of Intravitreal Bevacizumab Injection for the Treatment of Choroidal Neovascularization in Angioid Streaks
por: Lee, Ji Woong, et al.
Publicado: (2011)

Choroidal Neovascularization: Mechanisms of Endothelial Dysfunction
por: Yeo, Natalie Jia Ying, et al.
Publicado: (2019)

Fursultiamine Alleviates Choroidal Neovascularization by Suppressing Inflammation and Metabolic Reprogramming
por: Do, Ji Yeon, et al.
Publicado: (2020)

Choroidal neovascularization secondary to tuberculosis: Presentation and management()
por: Lee Kim, Esther, et al.
Publicado: (2017)

Choroidal Neovascularization Following Epiretinal Membrane Peeling
por: Bae, Ki Woong, et al.
Publicado: (2015)

Choroidal Neovascularization Secondary to Central Serous Chorioretinopathy: OCT Angiography Findings and Risk Factors
por: Yeo, Joon Hyung, et al.
Publicado: (2020)

Spectral domain-optical coherence tomography retinal biomarkers in choroidal neovascularization of multifocal choroiditis, myopic choroidal neovascularization, and idiopathic choroidal neovascularization
por: Gao, Rui, et al.
Publicado: (2021)

Gene Expression Profile and Functionality of ESC-Derived Lin-ckit+Sca-1+ Cells Are Distinct from Lin-ckit+Sca-1+ Cells Isolated from Fetal Liver or Bone Marrow
por: Fernandez, Irina, et al.
Publicado: (2012)

Occult choroidal neovascularization after successful macular hole surgery treated with ranibizumab
por: Oh, Ha Na, et al.
Publicado: (2012)

The Anti-angiogenic Effect of Chlorogenic Acid on Choroidal Neovascularization
por: Kim, Cinoo, et al.
Publicado: (2010)

Key Role of Microglial Matrix Metalloproteinases in Choroidal Neovascularization
por: Kim, Juhee, et al.
Publicado: (2021)

Antibody-Drug Conjugate Targeting c-Kit for the Treatment of Small Cell Lung Cancer
por: Kim, Kwang-Hyeok, et al.
Publicado: (2022)

Combined Treatment of Photodynamic Therapy and Bevacizumab for Choroidal Neovascularization Secondary to Age-Related Macular Degeneration
por: Kim, Hyun Woong, et al.
Publicado: (2011)

Melissa officinalis Extract Inhibits Laser-Induced Choroidal Neovascularization in a Rat Model
por: Lee, Eun Kyoung, et al.
Publicado: (2014)

Inflammatory Choroidal Neovascularization
por: Neri, Piergiorgi, et al.
Publicado: (2009)

Development of Highly Sensitive Digital Droplet PCR for Detection of cKIT Mutations in Circulating Free DNA That Mediate Resistance to TKI Treatment for Gastrointestinal Stromal Tumor (GIST)
por: Rassner, Michael, et al.
Publicado: (2023)

A novel anti‐c‐Kit antibody–drug conjugate to treat wild‐type and activating‐mutant c‐Kit‐positive tumors
por: Kim, Jin‐Ock, et al.
Publicado: (2021)

Anti-complement component 5 antibody targeting MG4 domain inhibits choroidal neovascularization
por: Jo, Dong Hyun, et al.
Publicado: (2017)

Risk factors for myopic choroidal neovascularization-related macular atrophy after anti-VEGF treatment
por: Bae, Ki Woong, et al.
Publicado: (2022)

CRISPR-LbCpf1 prevents choroidal neovascularization in a mouse model of age-related macular degeneration
por: Koo, Taeyoung, et al.
Publicado: (2018)

Bilateral Multifocal Choroidal Osteoma with Choroidal Neovascularization
por: MirNaghi, Mousavi, et al.
Publicado: (2015)

Photodynamic Therapy With Verteporfin for Choroidal Neovascularization in Patients with Angioid Streaks
por: Lee, Jun Mok, et al.
Publicado: (2007)

Photodynamic Therapy Combined with Intravitreal Bevacizumab in a Patient with Choroidal Neovascularization Secondary to Choroidal Osteoma
por: Jang, Jung Hyun, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_6envapd6kj7i7ve931h7hpf0uj