Cargando…

The Inhibition of Non-albicans Candida Species and Uncommon Yeast Pathogens by Selected Essential Oils and Their Major Compounds

The epidemiology of yeast infections and resistance to available antifungal drugs are rapidly increasing, and non-albicans Candida species and rare yeast species are increasingly emerging as major opportunistic pathogens. In order to identify new strategies to counter the threat of antimicrobial res...

Descripción completa

Detalles Bibliográficos
Autores principales: Mandras, Narcisa, Roana, Janira, Scalas, Daniela, Del Re, Simonetta, Cavallo, Lorenza, Ghisetti, Valeria, Tullio, Vivian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400735/
https://www.ncbi.nlm.nih.gov/pubmed/34443525
http://dx.doi.org/10.3390/molecules26164937
_version_ 1783745385390407680
author Mandras, Narcisa
Roana, Janira
Scalas, Daniela
Del Re, Simonetta
Cavallo, Lorenza
Ghisetti, Valeria
Tullio, Vivian
author_facet Mandras, Narcisa
Roana, Janira
Scalas, Daniela
Del Re, Simonetta
Cavallo, Lorenza
Ghisetti, Valeria
Tullio, Vivian
author_sort Mandras, Narcisa
collection PubMed
description The epidemiology of yeast infections and resistance to available antifungal drugs are rapidly increasing, and non-albicans Candida species and rare yeast species are increasingly emerging as major opportunistic pathogens. In order to identify new strategies to counter the threat of antimicrobial resistant microorganisms, essential oils (EOs) have become an important potential in the treatment of fungal infections. EOs and their bioactive pure compounds have been found to exhibit a wide range of remarkable biological activities. We investigated the in vitro antifungal activity of nine commercial EOs such as Thymus vulgaris (thyme red), Origanum vulgare (oregano), Lavandula vera (lavender), Pinus sylvestris (pine), Foeniculum vulgare (fennel), Melissa officinalis (lemon balm), Salvia officinalis (sage), Eugenia caryophyllata (clove) and Pelargonium asperum (geranium), and some of their main components (α-pinene, carvacrol, citronellal, eugenol, γ-terpinene, linalool, linalylacetate, terpinen-4-ol, thymol) against non-albicans Candida strains and uncommon yeasts. The EOs were analyzed by GC-MS, and their antifungal properties were evaluated by minimum inhibitory concentration and minimum fungicidal concentration parameters, in accordance with CLSI guidelines, with some modifications for EOs. Pine exhibited strong antifungal activity against the selected non-albicans Candida isolates and uncommon yeasts. In addition, lemon balm EOs and α-pinene exhibited strong antifungal activity against the selected non-albicans Candida yeasts. Thymol inhibited the growth of all uncommon yeasts. These data showed a promising potential application of EOs as natural adjuvant for management of infections by emerging non-albicans Candida species and uncommon pathogenic yeasts.
format Online
Article
Text
id pubmed-8400735
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84007352021-08-29 The Inhibition of Non-albicans Candida Species and Uncommon Yeast Pathogens by Selected Essential Oils and Their Major Compounds Mandras, Narcisa Roana, Janira Scalas, Daniela Del Re, Simonetta Cavallo, Lorenza Ghisetti, Valeria Tullio, Vivian Molecules Article The epidemiology of yeast infections and resistance to available antifungal drugs are rapidly increasing, and non-albicans Candida species and rare yeast species are increasingly emerging as major opportunistic pathogens. In order to identify new strategies to counter the threat of antimicrobial resistant microorganisms, essential oils (EOs) have become an important potential in the treatment of fungal infections. EOs and their bioactive pure compounds have been found to exhibit a wide range of remarkable biological activities. We investigated the in vitro antifungal activity of nine commercial EOs such as Thymus vulgaris (thyme red), Origanum vulgare (oregano), Lavandula vera (lavender), Pinus sylvestris (pine), Foeniculum vulgare (fennel), Melissa officinalis (lemon balm), Salvia officinalis (sage), Eugenia caryophyllata (clove) and Pelargonium asperum (geranium), and some of their main components (α-pinene, carvacrol, citronellal, eugenol, γ-terpinene, linalool, linalylacetate, terpinen-4-ol, thymol) against non-albicans Candida strains and uncommon yeasts. The EOs were analyzed by GC-MS, and their antifungal properties were evaluated by minimum inhibitory concentration and minimum fungicidal concentration parameters, in accordance with CLSI guidelines, with some modifications for EOs. Pine exhibited strong antifungal activity against the selected non-albicans Candida isolates and uncommon yeasts. In addition, lemon balm EOs and α-pinene exhibited strong antifungal activity against the selected non-albicans Candida yeasts. Thymol inhibited the growth of all uncommon yeasts. These data showed a promising potential application of EOs as natural adjuvant for management of infections by emerging non-albicans Candida species and uncommon pathogenic yeasts. MDPI 2021-08-15 /pmc/articles/PMC8400735/ /pubmed/34443525 http://dx.doi.org/10.3390/molecules26164937 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mandras, Narcisa
Roana, Janira
Scalas, Daniela
Del Re, Simonetta
Cavallo, Lorenza
Ghisetti, Valeria
Tullio, Vivian
The Inhibition of Non-albicans Candida Species and Uncommon Yeast Pathogens by Selected Essential Oils and Their Major Compounds
title The Inhibition of Non-albicans Candida Species and Uncommon Yeast Pathogens by Selected Essential Oils and Their Major Compounds
title_full The Inhibition of Non-albicans Candida Species and Uncommon Yeast Pathogens by Selected Essential Oils and Their Major Compounds
title_fullStr The Inhibition of Non-albicans Candida Species and Uncommon Yeast Pathogens by Selected Essential Oils and Their Major Compounds
title_full_unstemmed The Inhibition of Non-albicans Candida Species and Uncommon Yeast Pathogens by Selected Essential Oils and Their Major Compounds
title_short The Inhibition of Non-albicans Candida Species and Uncommon Yeast Pathogens by Selected Essential Oils and Their Major Compounds
title_sort inhibition of non-albicans candida species and uncommon yeast pathogens by selected essential oils and their major compounds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400735/
https://www.ncbi.nlm.nih.gov/pubmed/34443525
http://dx.doi.org/10.3390/molecules26164937
work_keys_str_mv AT mandrasnarcisa theinhibitionofnonalbicanscandidaspeciesanduncommonyeastpathogensbyselectedessentialoilsandtheirmajorcompounds
AT roanajanira theinhibitionofnonalbicanscandidaspeciesanduncommonyeastpathogensbyselectedessentialoilsandtheirmajorcompounds
AT scalasdaniela theinhibitionofnonalbicanscandidaspeciesanduncommonyeastpathogensbyselectedessentialoilsandtheirmajorcompounds
AT delresimonetta theinhibitionofnonalbicanscandidaspeciesanduncommonyeastpathogensbyselectedessentialoilsandtheirmajorcompounds
AT cavallolorenza theinhibitionofnonalbicanscandidaspeciesanduncommonyeastpathogensbyselectedessentialoilsandtheirmajorcompounds
AT ghisettivaleria theinhibitionofnonalbicanscandidaspeciesanduncommonyeastpathogensbyselectedessentialoilsandtheirmajorcompounds
AT tulliovivian theinhibitionofnonalbicanscandidaspeciesanduncommonyeastpathogensbyselectedessentialoilsandtheirmajorcompounds
AT mandrasnarcisa inhibitionofnonalbicanscandidaspeciesanduncommonyeastpathogensbyselectedessentialoilsandtheirmajorcompounds
AT roanajanira inhibitionofnonalbicanscandidaspeciesanduncommonyeastpathogensbyselectedessentialoilsandtheirmajorcompounds
AT scalasdaniela inhibitionofnonalbicanscandidaspeciesanduncommonyeastpathogensbyselectedessentialoilsandtheirmajorcompounds
AT delresimonetta inhibitionofnonalbicanscandidaspeciesanduncommonyeastpathogensbyselectedessentialoilsandtheirmajorcompounds
AT cavallolorenza inhibitionofnonalbicanscandidaspeciesanduncommonyeastpathogensbyselectedessentialoilsandtheirmajorcompounds
AT ghisettivaleria inhibitionofnonalbicanscandidaspeciesanduncommonyeastpathogensbyselectedessentialoilsandtheirmajorcompounds
AT tulliovivian inhibitionofnonalbicanscandidaspeciesanduncommonyeastpathogensbyselectedessentialoilsandtheirmajorcompounds