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Severe Pneumonia in Neonates Associated with Legionella pneumophila: Case Report and Review of the Literature
The causative agent of legionellosis is the Gram-negative intracellular bacteria Legionella spp. Its clinical presentation varies from a mild febrile illness called Pontiac fever to the severe and possible fatal pneumonia, Legionnaires’ disease. Immunocompromised patients, in particular, are affecte...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400773/ https://www.ncbi.nlm.nih.gov/pubmed/34451495 http://dx.doi.org/10.3390/pathogens10081031 |
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author | Perez Ortiz, Alba Hahn, Camilla Schaible, Thomas Rafat, Neysan Lange, Bettina |
author_facet | Perez Ortiz, Alba Hahn, Camilla Schaible, Thomas Rafat, Neysan Lange, Bettina |
author_sort | Perez Ortiz, Alba |
collection | PubMed |
description | The causative agent of legionellosis is the Gram-negative intracellular bacteria Legionella spp. Its clinical presentation varies from a mild febrile illness called Pontiac fever to the severe and possible fatal pneumonia, Legionnaires’ disease. Immunocompromised patients, in particular, are affected. Only a small number of infected neonates are described in the literature. Most of them have been associated with water birth or the use of air humidifiers. In the last five years, a growing number of cases have been reported in Germany by the national institute of disease surveillance and prevention (Robert-Koch Institute). Here, we describe a fatal case report of pulmonary legionellosis with acute respiratory distress syndrome (ARDS), sepsis, associated cutaneous manifestation, and extracorporeal membrane oxygenation in a full-term neonate. Moreover, we present a review of the literature discussing the epidemiology, risk factors, clinical features, diagnostics, treatment options, and prevention for this rare condition in neonates. |
format | Online Article Text |
id | pubmed-8400773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84007732021-08-29 Severe Pneumonia in Neonates Associated with Legionella pneumophila: Case Report and Review of the Literature Perez Ortiz, Alba Hahn, Camilla Schaible, Thomas Rafat, Neysan Lange, Bettina Pathogens Systematic Review The causative agent of legionellosis is the Gram-negative intracellular bacteria Legionella spp. Its clinical presentation varies from a mild febrile illness called Pontiac fever to the severe and possible fatal pneumonia, Legionnaires’ disease. Immunocompromised patients, in particular, are affected. Only a small number of infected neonates are described in the literature. Most of them have been associated with water birth or the use of air humidifiers. In the last five years, a growing number of cases have been reported in Germany by the national institute of disease surveillance and prevention (Robert-Koch Institute). Here, we describe a fatal case report of pulmonary legionellosis with acute respiratory distress syndrome (ARDS), sepsis, associated cutaneous manifestation, and extracorporeal membrane oxygenation in a full-term neonate. Moreover, we present a review of the literature discussing the epidemiology, risk factors, clinical features, diagnostics, treatment options, and prevention for this rare condition in neonates. MDPI 2021-08-15 /pmc/articles/PMC8400773/ /pubmed/34451495 http://dx.doi.org/10.3390/pathogens10081031 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Perez Ortiz, Alba Hahn, Camilla Schaible, Thomas Rafat, Neysan Lange, Bettina Severe Pneumonia in Neonates Associated with Legionella pneumophila: Case Report and Review of the Literature |
title | Severe Pneumonia in Neonates Associated with Legionella pneumophila: Case Report and Review of the Literature |
title_full | Severe Pneumonia in Neonates Associated with Legionella pneumophila: Case Report and Review of the Literature |
title_fullStr | Severe Pneumonia in Neonates Associated with Legionella pneumophila: Case Report and Review of the Literature |
title_full_unstemmed | Severe Pneumonia in Neonates Associated with Legionella pneumophila: Case Report and Review of the Literature |
title_short | Severe Pneumonia in Neonates Associated with Legionella pneumophila: Case Report and Review of the Literature |
title_sort | severe pneumonia in neonates associated with legionella pneumophila: case report and review of the literature |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400773/ https://www.ncbi.nlm.nih.gov/pubmed/34451495 http://dx.doi.org/10.3390/pathogens10081031 |
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