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Ethnic Disparities in the Development of Sight-Threatening Diabetic Retinopathy in a UK Multi-Ethnic Population with Diabetes: An Observational Cohort Study

There is little data on ethnic differences in incidence of DR and sight threatening DR (STDR) in the United Kingdom. We aimed to determine ethnic differences in the development of DR and STDR and to identify risk factors of DR and STDR in people with incident or prevalent type II diabetes (T2DM). We...

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Autores principales: Nugawela, Manjula D., Gurudas, Sarega, Prevost, A Toby, Mathur, Rohini, Robson, John, Hanif, Wasim, Majeed, Azeem, Sivaprasad, Sobha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400788/
https://www.ncbi.nlm.nih.gov/pubmed/34442384
http://dx.doi.org/10.3390/jpm11080740
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author Nugawela, Manjula D.
Gurudas, Sarega
Prevost, A Toby
Mathur, Rohini
Robson, John
Hanif, Wasim
Majeed, Azeem
Sivaprasad, Sobha
author_facet Nugawela, Manjula D.
Gurudas, Sarega
Prevost, A Toby
Mathur, Rohini
Robson, John
Hanif, Wasim
Majeed, Azeem
Sivaprasad, Sobha
author_sort Nugawela, Manjula D.
collection PubMed
description There is little data on ethnic differences in incidence of DR and sight threatening DR (STDR) in the United Kingdom. We aimed to determine ethnic differences in the development of DR and STDR and to identify risk factors of DR and STDR in people with incident or prevalent type II diabetes (T2DM). We used electronic primary care medical records of people registered with 134 general practices in East London during the period from January 2007–January 2017. There were 58,216 people with T2DM eligible to be included in the study. Among people with newly diagnosed T2DM, Indian, Pakistani and African ethnic groups showed an increased risk of DR with Africans having highest risk of STDR compared to White ethnic groups (HR: 1.36 95% CI 1.02–1.83). Among those with prevalent T2DM, Indian, Pakistani, Bangladeshi and Caribbean ethnic groups showed increased risk of DR and STDR with Indian having the highest risk of any DR (HR: 1.24 95% CI 1.16–1.32) and STDR (HR: 1.38 95% CI 1.17–1.63) compared with Whites after adjusting for all covariates considered. It is important to optimise prevention, screening and treatment options in these ethnic minority groups to avoid health inequalities in diabetes eye care.
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spelling pubmed-84007882021-08-29 Ethnic Disparities in the Development of Sight-Threatening Diabetic Retinopathy in a UK Multi-Ethnic Population with Diabetes: An Observational Cohort Study Nugawela, Manjula D. Gurudas, Sarega Prevost, A Toby Mathur, Rohini Robson, John Hanif, Wasim Majeed, Azeem Sivaprasad, Sobha J Pers Med Article There is little data on ethnic differences in incidence of DR and sight threatening DR (STDR) in the United Kingdom. We aimed to determine ethnic differences in the development of DR and STDR and to identify risk factors of DR and STDR in people with incident or prevalent type II diabetes (T2DM). We used electronic primary care medical records of people registered with 134 general practices in East London during the period from January 2007–January 2017. There were 58,216 people with T2DM eligible to be included in the study. Among people with newly diagnosed T2DM, Indian, Pakistani and African ethnic groups showed an increased risk of DR with Africans having highest risk of STDR compared to White ethnic groups (HR: 1.36 95% CI 1.02–1.83). Among those with prevalent T2DM, Indian, Pakistani, Bangladeshi and Caribbean ethnic groups showed increased risk of DR and STDR with Indian having the highest risk of any DR (HR: 1.24 95% CI 1.16–1.32) and STDR (HR: 1.38 95% CI 1.17–1.63) compared with Whites after adjusting for all covariates considered. It is important to optimise prevention, screening and treatment options in these ethnic minority groups to avoid health inequalities in diabetes eye care. MDPI 2021-07-28 /pmc/articles/PMC8400788/ /pubmed/34442384 http://dx.doi.org/10.3390/jpm11080740 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nugawela, Manjula D.
Gurudas, Sarega
Prevost, A Toby
Mathur, Rohini
Robson, John
Hanif, Wasim
Majeed, Azeem
Sivaprasad, Sobha
Ethnic Disparities in the Development of Sight-Threatening Diabetic Retinopathy in a UK Multi-Ethnic Population with Diabetes: An Observational Cohort Study
title Ethnic Disparities in the Development of Sight-Threatening Diabetic Retinopathy in a UK Multi-Ethnic Population with Diabetes: An Observational Cohort Study
title_full Ethnic Disparities in the Development of Sight-Threatening Diabetic Retinopathy in a UK Multi-Ethnic Population with Diabetes: An Observational Cohort Study
title_fullStr Ethnic Disparities in the Development of Sight-Threatening Diabetic Retinopathy in a UK Multi-Ethnic Population with Diabetes: An Observational Cohort Study
title_full_unstemmed Ethnic Disparities in the Development of Sight-Threatening Diabetic Retinopathy in a UK Multi-Ethnic Population with Diabetes: An Observational Cohort Study
title_short Ethnic Disparities in the Development of Sight-Threatening Diabetic Retinopathy in a UK Multi-Ethnic Population with Diabetes: An Observational Cohort Study
title_sort ethnic disparities in the development of sight-threatening diabetic retinopathy in a uk multi-ethnic population with diabetes: an observational cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400788/
https://www.ncbi.nlm.nih.gov/pubmed/34442384
http://dx.doi.org/10.3390/jpm11080740
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