Immunodominant Cytomegalovirus Epitopes Suppress Subdominant Epitopes in the Generation of High-Avidity CD8 T Cells

CD8(+) T-cell responses to pathogens are directed against infected cells that present pathogen-encoded peptides on MHC class-I molecules. Although natural responses are polyclonal, the spectrum of peptides that qualify for epitopes is remarkably small even for pathogens with high coding capacity. Am...

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Detalles Bibliográficos
Autores principales: Freitag, Kirsten, Hamdan, Sara, Reddehase, Matthias J., Holtappels, Rafaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400798/
https://www.ncbi.nlm.nih.gov/pubmed/34451420
http://dx.doi.org/10.3390/pathogens10080956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400798/
https://www.ncbi.nlm.nih.gov/pubmed/34451420
http://dx.doi.org/10.3390/pathogens10080956

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