Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach

Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical...

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Detalles Bibliográficos
Autores principales: Mitrović, Jelena R., Divović-Matović, Branka, Knutson, Daniel E., Đoković, Jelena B., Kremenović, Aleksandar, Dobričić, Vladimir D., Randjelović, Danijela V., Pantelić, Ivana, Cook, James M., Savić, Miroslav M., Savić, Snežana D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400889/
https://www.ncbi.nlm.nih.gov/pubmed/34452149
http://dx.doi.org/10.3390/pharmaceutics13081188

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