The Prognostic Role of Micro-RNAs in Head and Neck Cancers: An Umbrella Review

We conducted an umbrella review which synthetizes the findings of systematic reviews available in the literature that investigate the prognostic role of miRNAs as potential biomarkers in the field of tertiary prevention of head and neck Cancer (HNC). We selected systematic reviews in English related...

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Autores principales: Mariani, Marco, Castagna, Carolina, Boccia, Stefania, Pastorino, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Systematic Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400907/
https://www.ncbi.nlm.nih.gov/pubmed/34442465
http://dx.doi.org/10.3390/jpm11080821
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author Mariani, Marco
Castagna, Carolina
Boccia, Stefania
Pastorino, Roberta
author_facet Mariani, Marco
Castagna, Carolina
Boccia, Stefania
Pastorino, Roberta
author_sort Mariani, Marco
collection PubMed
description We conducted an umbrella review which synthetizes the findings of systematic reviews available in the literature that investigate the prognostic role of miRNAs as potential biomarkers in the field of tertiary prevention of head and neck Cancer (HNC). We selected systematic reviews in English related to HNC, with meta-analysis of observational studies that reported quantitative prognostic measures, hazard ratios (HRs), overall survival (OS) or disease-free survival (DFS). The methodological quality of the included reviews was assessed by using the AMSTAR-2 tool. The most reported miRNAs were the following: miRNA2, Let7 family and miR17, etc. Four out of six reviews particularly emphasized the link between miRNA21 expression and HNC patients. Recently the cumulative effects of sets of miRNAs have been increasingly studied and might be a stronger predictor of survival than single miRNA.
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spelling pubmed-84009072021-08-29 The Prognostic Role of Micro-RNAs in Head and Neck Cancers: An Umbrella Review Mariani, Marco Castagna, Carolina Boccia, Stefania Pastorino, Roberta J Pers Med Systematic Review We conducted an umbrella review which synthetizes the findings of systematic reviews available in the literature that investigate the prognostic role of miRNAs as potential biomarkers in the field of tertiary prevention of head and neck Cancer (HNC). We selected systematic reviews in English related to HNC, with meta-analysis of observational studies that reported quantitative prognostic measures, hazard ratios (HRs), overall survival (OS) or disease-free survival (DFS). The methodological quality of the included reviews was assessed by using the AMSTAR-2 tool. The most reported miRNAs were the following: miRNA2, Let7 family and miR17, etc. Four out of six reviews particularly emphasized the link between miRNA21 expression and HNC patients. Recently the cumulative effects of sets of miRNAs have been increasingly studied and might be a stronger predictor of survival than single miRNA. MDPI 2021-08-21 /pmc/articles/PMC8400907/ /pubmed/34442465 http://dx.doi.org/10.3390/jpm11080821 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Mariani, Marco
Castagna, Carolina
Boccia, Stefania
Pastorino, Roberta
The Prognostic Role of Micro-RNAs in Head and Neck Cancers: An Umbrella Review
title The Prognostic Role of Micro-RNAs in Head and Neck Cancers: An Umbrella Review
title_full The Prognostic Role of Micro-RNAs in Head and Neck Cancers: An Umbrella Review
title_fullStr The Prognostic Role of Micro-RNAs in Head and Neck Cancers: An Umbrella Review
title_full_unstemmed The Prognostic Role of Micro-RNAs in Head and Neck Cancers: An Umbrella Review
title_short The Prognostic Role of Micro-RNAs in Head and Neck Cancers: An Umbrella Review
title_sort prognostic role of micro-rnas in head and neck cancers: an umbrella review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400907/
https://www.ncbi.nlm.nih.gov/pubmed/34442465
http://dx.doi.org/10.3390/jpm11080821
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