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Preclinical Toxicity and Safety of MM-129—First-in-Class BTK/PD-L1 Inhibitor as a Potential Candidate against Colon Cancer

MM-129 is a novel inhibitor targeting BTK/PI3K/AKT/mTOR and PD-L1, as it possesses antitumor activity against colon cancer. To evaluate the safety profile of MM-129, we conducted a toxicity study using the zebrafish and rodent model. MM-129 was also assessed for pharmacokinetics features through an...

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Detalles Bibliográficos
Autores principales:	Hermanowicz, Justyna Magdalena, Kalaska, Bartlomiej, Pawlak, Krystyna, Sieklucka, Beata, Miklosz, Joanna, Mojzych, Mariusz, Pawlak, Dariusz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400941/ https://www.ncbi.nlm.nih.gov/pubmed/34452183 http://dx.doi.org/10.3390/pharmaceutics13081222

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