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Cancer Cell Membrane-Coated Nanosuspensions for Enhanced Chemotherapeutic Treatment of Glioma

Effective intracerebral delivery is key for glioma treatment. However, the drug delivery system within the brain is largely limited by its own adverse physical and chemical properties, low targeting efficiency, the blood–brain barrier and the blood–brain tumor barrier. Herein, we developed a simple,...

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Autores principales: Fan, Yueyue, Hao, Wenyan, Cui, Yuexin, Chen, Mengyu, Chu, Xiaoyang, Yang, Yang, Wang, Yuli, Gao, Chunsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400986/
https://www.ncbi.nlm.nih.gov/pubmed/34443689
http://dx.doi.org/10.3390/molecules26165103
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author Fan, Yueyue
Hao, Wenyan
Cui, Yuexin
Chen, Mengyu
Chu, Xiaoyang
Yang, Yang
Wang, Yuli
Gao, Chunsheng
author_facet Fan, Yueyue
Hao, Wenyan
Cui, Yuexin
Chen, Mengyu
Chu, Xiaoyang
Yang, Yang
Wang, Yuli
Gao, Chunsheng
author_sort Fan, Yueyue
collection PubMed
description Effective intracerebral delivery is key for glioma treatment. However, the drug delivery system within the brain is largely limited by its own adverse physical and chemical properties, low targeting efficiency, the blood–brain barrier and the blood–brain tumor barrier. Herein, we developed a simple, safe and efficient biomimetic nanosuspension. The C6 cell membrane (CCM) was utilized to camouflaged the 10-hydroxycamptothecin nanosuspension (HCPT-NS) in order to obtain HCPT-NS/CCM. Through the use of immune escape and homotypic binding of the cancer cell membrane, HCPT-NS/CCM was able to penetrate the blood–brain barrier and target tumors. The HCPT-NS is only comprised of drugs, as well as a small amount of stabilizers that are characterized by a simple preparation method and high drug loading. Similarly, the HCPT-NS/CCM is able to achieve targeted treatment of glioma without any ligand modification, which leads it to be stable and efficient. Cellular uptake and in vivo imaging experiments demonstrated that HCPT-NS/CCM is able to effectively cross the blood–brain barrier and was concentrated at the glioma site due to the natural homing pathway. Our results reveal that the glioma cancer cell membrane is able to promote drug transport into the brain and enter the tumor via a homologous targeting mechanism.
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spelling pubmed-84009862021-08-29 Cancer Cell Membrane-Coated Nanosuspensions for Enhanced Chemotherapeutic Treatment of Glioma Fan, Yueyue Hao, Wenyan Cui, Yuexin Chen, Mengyu Chu, Xiaoyang Yang, Yang Wang, Yuli Gao, Chunsheng Molecules Article Effective intracerebral delivery is key for glioma treatment. However, the drug delivery system within the brain is largely limited by its own adverse physical and chemical properties, low targeting efficiency, the blood–brain barrier and the blood–brain tumor barrier. Herein, we developed a simple, safe and efficient biomimetic nanosuspension. The C6 cell membrane (CCM) was utilized to camouflaged the 10-hydroxycamptothecin nanosuspension (HCPT-NS) in order to obtain HCPT-NS/CCM. Through the use of immune escape and homotypic binding of the cancer cell membrane, HCPT-NS/CCM was able to penetrate the blood–brain barrier and target tumors. The HCPT-NS is only comprised of drugs, as well as a small amount of stabilizers that are characterized by a simple preparation method and high drug loading. Similarly, the HCPT-NS/CCM is able to achieve targeted treatment of glioma without any ligand modification, which leads it to be stable and efficient. Cellular uptake and in vivo imaging experiments demonstrated that HCPT-NS/CCM is able to effectively cross the blood–brain barrier and was concentrated at the glioma site due to the natural homing pathway. Our results reveal that the glioma cancer cell membrane is able to promote drug transport into the brain and enter the tumor via a homologous targeting mechanism. MDPI 2021-08-23 /pmc/articles/PMC8400986/ /pubmed/34443689 http://dx.doi.org/10.3390/molecules26165103 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fan, Yueyue
Hao, Wenyan
Cui, Yuexin
Chen, Mengyu
Chu, Xiaoyang
Yang, Yang
Wang, Yuli
Gao, Chunsheng
Cancer Cell Membrane-Coated Nanosuspensions for Enhanced Chemotherapeutic Treatment of Glioma
title Cancer Cell Membrane-Coated Nanosuspensions for Enhanced Chemotherapeutic Treatment of Glioma
title_full Cancer Cell Membrane-Coated Nanosuspensions for Enhanced Chemotherapeutic Treatment of Glioma
title_fullStr Cancer Cell Membrane-Coated Nanosuspensions for Enhanced Chemotherapeutic Treatment of Glioma
title_full_unstemmed Cancer Cell Membrane-Coated Nanosuspensions for Enhanced Chemotherapeutic Treatment of Glioma
title_short Cancer Cell Membrane-Coated Nanosuspensions for Enhanced Chemotherapeutic Treatment of Glioma
title_sort cancer cell membrane-coated nanosuspensions for enhanced chemotherapeutic treatment of glioma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400986/
https://www.ncbi.nlm.nih.gov/pubmed/34443689
http://dx.doi.org/10.3390/molecules26165103
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