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Screening for Glucose Metabolism Disorders, Assessment the Disse Insulin Resistance Index and Hospital Prognosis of Coronary Artery Bypass Surgery

Objective: To study insulin resistance markers and their relationship with preoperative status and hospital complications of coronary artery bypass grafting (CABG) in patients with type 2 diabetes, prediabetes and normoglycemia. Methods: We included 383 consecutive patients who underwent CABG. Patie...

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Autores principales: Sumin, Alexey N., Bezdenezhnykh, Natalia A., Bezdenezhnykh, Andrey V., Osokina, Anastasia V., Kuz’mina, Anastasiya A., Tsepokina, Anna V., Barbarash, Olga L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401009/
https://www.ncbi.nlm.nih.gov/pubmed/34442446
http://dx.doi.org/10.3390/jpm11080802
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author Sumin, Alexey N.
Bezdenezhnykh, Natalia A.
Bezdenezhnykh, Andrey V.
Osokina, Anastasia V.
Kuz’mina, Anastasiya A.
Tsepokina, Anna V.
Barbarash, Olga L.
author_facet Sumin, Alexey N.
Bezdenezhnykh, Natalia A.
Bezdenezhnykh, Andrey V.
Osokina, Anastasia V.
Kuz’mina, Anastasiya A.
Tsepokina, Anna V.
Barbarash, Olga L.
author_sort Sumin, Alexey N.
collection PubMed
description Objective: To study insulin resistance markers and their relationship with preoperative status and hospital complications of coronary artery bypass grafting (CABG) in patients with type 2 diabetes, prediabetes and normoglycemia. Methods: We included 383 consecutive patients who underwent CABG. Patients were divided into two groups—with carbohydrate metabolism disorders (CMD, n = 192) and without CMD (n = 191). Free fatty acids and fasting insulin in plasma were determined, and the Disse, QUICKI and revised QUICKI indices were calculated in all patients. Perioperative characteristics and postoperative complications were analyzed in these groups, and their relations with markers of insulin resistance. Results: Screening before CABG increased the number of patients with CMD from 25.3% to 50.1%. Incidence of postoperative stroke (p = 0.044), and hospital stay after CABG > 30 days (p = 0.014) was greater in CMD patients. Logistic regression analysis revealed that an increase in left atrial size, age, aortic clamping time, and decrease in Disse index were independently associated with hospital stay >10 days and/or perioperative complications. Conclusions: Screening for CMD before CABG increased the patient number with prediabetes and type 2 diabetes. In the CMD group, there were more frequent hospital complications. The Disse index was an independent predictor of long hospital stay and/or poor outcomes.
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spelling pubmed-84010092021-08-29 Screening for Glucose Metabolism Disorders, Assessment the Disse Insulin Resistance Index and Hospital Prognosis of Coronary Artery Bypass Surgery Sumin, Alexey N. Bezdenezhnykh, Natalia A. Bezdenezhnykh, Andrey V. Osokina, Anastasia V. Kuz’mina, Anastasiya A. Tsepokina, Anna V. Barbarash, Olga L. J Pers Med Article Objective: To study insulin resistance markers and their relationship with preoperative status and hospital complications of coronary artery bypass grafting (CABG) in patients with type 2 diabetes, prediabetes and normoglycemia. Methods: We included 383 consecutive patients who underwent CABG. Patients were divided into two groups—with carbohydrate metabolism disorders (CMD, n = 192) and without CMD (n = 191). Free fatty acids and fasting insulin in plasma were determined, and the Disse, QUICKI and revised QUICKI indices were calculated in all patients. Perioperative characteristics and postoperative complications were analyzed in these groups, and their relations with markers of insulin resistance. Results: Screening before CABG increased the number of patients with CMD from 25.3% to 50.1%. Incidence of postoperative stroke (p = 0.044), and hospital stay after CABG > 30 days (p = 0.014) was greater in CMD patients. Logistic regression analysis revealed that an increase in left atrial size, age, aortic clamping time, and decrease in Disse index were independently associated with hospital stay >10 days and/or perioperative complications. Conclusions: Screening for CMD before CABG increased the patient number with prediabetes and type 2 diabetes. In the CMD group, there were more frequent hospital complications. The Disse index was an independent predictor of long hospital stay and/or poor outcomes. MDPI 2021-08-17 /pmc/articles/PMC8401009/ /pubmed/34442446 http://dx.doi.org/10.3390/jpm11080802 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sumin, Alexey N.
Bezdenezhnykh, Natalia A.
Bezdenezhnykh, Andrey V.
Osokina, Anastasia V.
Kuz’mina, Anastasiya A.
Tsepokina, Anna V.
Barbarash, Olga L.
Screening for Glucose Metabolism Disorders, Assessment the Disse Insulin Resistance Index and Hospital Prognosis of Coronary Artery Bypass Surgery
title Screening for Glucose Metabolism Disorders, Assessment the Disse Insulin Resistance Index and Hospital Prognosis of Coronary Artery Bypass Surgery
title_full Screening for Glucose Metabolism Disorders, Assessment the Disse Insulin Resistance Index and Hospital Prognosis of Coronary Artery Bypass Surgery
title_fullStr Screening for Glucose Metabolism Disorders, Assessment the Disse Insulin Resistance Index and Hospital Prognosis of Coronary Artery Bypass Surgery
title_full_unstemmed Screening for Glucose Metabolism Disorders, Assessment the Disse Insulin Resistance Index and Hospital Prognosis of Coronary Artery Bypass Surgery
title_short Screening for Glucose Metabolism Disorders, Assessment the Disse Insulin Resistance Index and Hospital Prognosis of Coronary Artery Bypass Surgery
title_sort screening for glucose metabolism disorders, assessment the disse insulin resistance index and hospital prognosis of coronary artery bypass surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401009/
https://www.ncbi.nlm.nih.gov/pubmed/34442446
http://dx.doi.org/10.3390/jpm11080802
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