Functional Characterization of 21 Rare Allelic CYP1A2 Variants Identified in a Population of 4773 Japanese Individuals by Assessing Phenacetin O-Deethylation

Cytochrome P450 1A2 (CYP1A2), which accounts for approximately 13% of the total hepatic cytochrome content, catalyzes the metabolic reactions of approximately 9% of frequently used drugs, including theophylline and olanzapine. Substantial inter-individual differences in enzymatic activity have been...

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Detalles Bibliográficos
Autores principales: Kumondai, Masaki, Gutiérrez Rico, Evelyn Marie, Hishinuma, Eiji, Nakanishi, Yuya, Yamazaki, Shuki, Ueda, Akiko, Saito, Sakae, Tadaka, Shu, Kinoshita, Kengo, Saigusa, Daisuke, Nakayoshi, Tomoki, Oda, Akifumi, Hirasawa, Noriyasu, Hiratsuka, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401128/
https://www.ncbi.nlm.nih.gov/pubmed/34442334
http://dx.doi.org/10.3390/jpm11080690

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