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Escherichiacoli Nissle 1917 as a Novel Microrobot for Tumor-Targeted Imaging and Therapy

Highly efficient drug delivery systems with excellent tumor selectivity and minimal toxicity to normal tissues remain challenging for tumor treatment. Although great effort has been made to prolong the blood circulation and improve the delivery efficiency to tumor sites, nanomedicines are rarely app...

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Detalles Bibliográficos
Autores principales: Liu, Qingyao, Gai, Yongkang, Chen, Yaqi, Lan, Xiaoli, Jiang, Dawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401140/
https://www.ncbi.nlm.nih.gov/pubmed/34452187
http://dx.doi.org/10.3390/pharmaceutics13081226
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author Liu, Qingyao
Gai, Yongkang
Chen, Yaqi
Lan, Xiaoli
Jiang, Dawei
author_facet Liu, Qingyao
Gai, Yongkang
Chen, Yaqi
Lan, Xiaoli
Jiang, Dawei
author_sort Liu, Qingyao
collection PubMed
description Highly efficient drug delivery systems with excellent tumor selectivity and minimal toxicity to normal tissues remain challenging for tumor treatment. Although great effort has been made to prolong the blood circulation and improve the delivery efficiency to tumor sites, nanomedicines are rarely approved for clinical application. Bacteria have the inherent properties of homing to solid tumors, presenting themselves as promising drug delivery systems. Escherichia coli Nissle 1917 (EcN) is a commonly used probiotic in clinical practice. Its facultative anaerobic property drives it to selectively colonize in the hypoxic area of the tumor for survival and reproduction. EcN can be engineered as a bacteria-based microrobot for molecular imaging, drug delivery, and gene delivery. This review summarizes the progress in EcN-mediated tumor imaging and therapy and discusses the prospects and challenges for its clinical application. EcN provides a new idea as a delivery vehicle and will be a powerful weapon against cancer.
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spelling pubmed-84011402021-08-29 Escherichiacoli Nissle 1917 as a Novel Microrobot for Tumor-Targeted Imaging and Therapy Liu, Qingyao Gai, Yongkang Chen, Yaqi Lan, Xiaoli Jiang, Dawei Pharmaceutics Review Highly efficient drug delivery systems with excellent tumor selectivity and minimal toxicity to normal tissues remain challenging for tumor treatment. Although great effort has been made to prolong the blood circulation and improve the delivery efficiency to tumor sites, nanomedicines are rarely approved for clinical application. Bacteria have the inherent properties of homing to solid tumors, presenting themselves as promising drug delivery systems. Escherichia coli Nissle 1917 (EcN) is a commonly used probiotic in clinical practice. Its facultative anaerobic property drives it to selectively colonize in the hypoxic area of the tumor for survival and reproduction. EcN can be engineered as a bacteria-based microrobot for molecular imaging, drug delivery, and gene delivery. This review summarizes the progress in EcN-mediated tumor imaging and therapy and discusses the prospects and challenges for its clinical application. EcN provides a new idea as a delivery vehicle and will be a powerful weapon against cancer. MDPI 2021-08-09 /pmc/articles/PMC8401140/ /pubmed/34452187 http://dx.doi.org/10.3390/pharmaceutics13081226 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Qingyao
Gai, Yongkang
Chen, Yaqi
Lan, Xiaoli
Jiang, Dawei
Escherichiacoli Nissle 1917 as a Novel Microrobot for Tumor-Targeted Imaging and Therapy
title Escherichiacoli Nissle 1917 as a Novel Microrobot for Tumor-Targeted Imaging and Therapy
title_full Escherichiacoli Nissle 1917 as a Novel Microrobot for Tumor-Targeted Imaging and Therapy
title_fullStr Escherichiacoli Nissle 1917 as a Novel Microrobot for Tumor-Targeted Imaging and Therapy
title_full_unstemmed Escherichiacoli Nissle 1917 as a Novel Microrobot for Tumor-Targeted Imaging and Therapy
title_short Escherichiacoli Nissle 1917 as a Novel Microrobot for Tumor-Targeted Imaging and Therapy
title_sort escherichiacoli nissle 1917 as a novel microrobot for tumor-targeted imaging and therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401140/
https://www.ncbi.nlm.nih.gov/pubmed/34452187
http://dx.doi.org/10.3390/pharmaceutics13081226
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