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Uncovering cancer vulnerabilities by machine learning prediction of synthetic lethality

BACKGROUND: Synthetic lethality describes a genetic interaction between two perturbations, leading to cell death, whereas neither event alone has a significant effect on cell viability. This concept can be exploited to specifically target tumor cells. CRISPR viability screens have been widely employ...

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Detalles Bibliográficos
Autores principales:	Benfatto, Salvatore, Serçin, Özdemirhan, Dejure, Francesca R., Abdollahi, Amir, Zenke, Frank T., Mardin, Balca R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401190/ https://www.ncbi.nlm.nih.gov/pubmed/34454516 http://dx.doi.org/10.1186/s12943-021-01405-8

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