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Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness

Skeletal muscle wasting in the intensive care unit (ICU) has been associated with mortality, but it is unclear whether sarcopenia, defined by skeletal muscle mass and function, is useful for detailed risk stratification after ICU discharge. In this cohort study, 72 critically ill patients with an IC...

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Autores principales: Yanagi, Naoya, Koike, Tomotaka, Kamiya, Kentaro, Hamazaki, Nobuaki, Nozaki, Kohei, Ichikawa, Takafumi, Matsunaga, Atsuhiko, Kuroiwa, Masayuki, Arai, Masayasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401251/
https://www.ncbi.nlm.nih.gov/pubmed/34444886
http://dx.doi.org/10.3390/nu13082726
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author Yanagi, Naoya
Koike, Tomotaka
Kamiya, Kentaro
Hamazaki, Nobuaki
Nozaki, Kohei
Ichikawa, Takafumi
Matsunaga, Atsuhiko
Kuroiwa, Masayuki
Arai, Masayasu
author_facet Yanagi, Naoya
Koike, Tomotaka
Kamiya, Kentaro
Hamazaki, Nobuaki
Nozaki, Kohei
Ichikawa, Takafumi
Matsunaga, Atsuhiko
Kuroiwa, Masayuki
Arai, Masayasu
author_sort Yanagi, Naoya
collection PubMed
description Skeletal muscle wasting in the intensive care unit (ICU) has been associated with mortality, but it is unclear whether sarcopenia, defined by skeletal muscle mass and function, is useful for detailed risk stratification after ICU discharge. In this cohort study, 72 critically ill patients with an ICU stay of ≥48 h were identified. Skeletal muscle mass was assessed from the muscle thickness (MT) of the patients’ quadriceps using ultrasound images before ICU discharge. Skeletal muscle function was assessed from the patients’ muscle strength (MS) before ICU discharge according to the Medical Research Council sum score. A diagnosis of sarcopenia in the ICU was made in patients with low MT and low MS. The study endpoint was 1-year mortality. Sarcopenia in the ICU was diagnosed in 26/72 patients (36%). After adjusting for covariates in the Cox regression, sarcopenia in the ICU was significantly associated with 1-year mortality (hazard ratio 3.82; 95% confidence interval, 1.40–10.42). Sarcopenia in the ICU, defined by low skeletal muscle mass and function, was associated with 1-year mortality in survivors of critical illness. Skeletal muscle mass and function assessed at the bedside could be used to identify higher-risk patients in the ICU.
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spelling pubmed-84012512021-08-29 Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness Yanagi, Naoya Koike, Tomotaka Kamiya, Kentaro Hamazaki, Nobuaki Nozaki, Kohei Ichikawa, Takafumi Matsunaga, Atsuhiko Kuroiwa, Masayuki Arai, Masayasu Nutrients Article Skeletal muscle wasting in the intensive care unit (ICU) has been associated with mortality, but it is unclear whether sarcopenia, defined by skeletal muscle mass and function, is useful for detailed risk stratification after ICU discharge. In this cohort study, 72 critically ill patients with an ICU stay of ≥48 h were identified. Skeletal muscle mass was assessed from the muscle thickness (MT) of the patients’ quadriceps using ultrasound images before ICU discharge. Skeletal muscle function was assessed from the patients’ muscle strength (MS) before ICU discharge according to the Medical Research Council sum score. A diagnosis of sarcopenia in the ICU was made in patients with low MT and low MS. The study endpoint was 1-year mortality. Sarcopenia in the ICU was diagnosed in 26/72 patients (36%). After adjusting for covariates in the Cox regression, sarcopenia in the ICU was significantly associated with 1-year mortality (hazard ratio 3.82; 95% confidence interval, 1.40–10.42). Sarcopenia in the ICU, defined by low skeletal muscle mass and function, was associated with 1-year mortality in survivors of critical illness. Skeletal muscle mass and function assessed at the bedside could be used to identify higher-risk patients in the ICU. MDPI 2021-08-08 /pmc/articles/PMC8401251/ /pubmed/34444886 http://dx.doi.org/10.3390/nu13082726 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yanagi, Naoya
Koike, Tomotaka
Kamiya, Kentaro
Hamazaki, Nobuaki
Nozaki, Kohei
Ichikawa, Takafumi
Matsunaga, Atsuhiko
Kuroiwa, Masayuki
Arai, Masayasu
Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness
title Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness
title_full Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness
title_fullStr Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness
title_full_unstemmed Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness
title_short Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness
title_sort assessment of sarcopenia in the intensive care unit and 1-year mortality in survivors of critical illness
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401251/
https://www.ncbi.nlm.nih.gov/pubmed/34444886
http://dx.doi.org/10.3390/nu13082726
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