Mesenchymal Stromal Cells Perspective: New Potential Therapeutic for the Treatment of Neurological Diseases

Several studies have shown that mesenchymal stromal/stem cells (MSCs) exert their neuroprotective and neurorestorative efficacy via the secretion of neurotrophic factors. Based on these studies, many clinical trials using MSCs for the treatment of neurological disorders have been conducted, and resu...

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Detalles Bibliográficos
Autores principales: Mukai, Takeo, Sei, Kenshi, Nagamura-Inoue, Tokiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401282/
https://www.ncbi.nlm.nih.gov/pubmed/34452120
http://dx.doi.org/10.3390/pharmaceutics13081159
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author Mukai, Takeo
Sei, Kenshi
Nagamura-Inoue, Tokiko
author_facet Mukai, Takeo
Sei, Kenshi
Nagamura-Inoue, Tokiko
author_sort Mukai, Takeo
collection PubMed
description Several studies have shown that mesenchymal stromal/stem cells (MSCs) exert their neuroprotective and neurorestorative efficacy via the secretion of neurotrophic factors. Based on these studies, many clinical trials using MSCs for the treatment of neurological disorders have been conducted, and results regarding their feasibility and efficacy have been reported. The present review aims to highlight the characteristics and basic research regarding the role of MSCs in neurological disease and to discuss the recent progress in clinical trials using MSCs to treat various neurological disorders.
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spelling pubmed-84012822021-08-29 Mesenchymal Stromal Cells Perspective: New Potential Therapeutic for the Treatment of Neurological Diseases Mukai, Takeo Sei, Kenshi Nagamura-Inoue, Tokiko Pharmaceutics Review Several studies have shown that mesenchymal stromal/stem cells (MSCs) exert their neuroprotective and neurorestorative efficacy via the secretion of neurotrophic factors. Based on these studies, many clinical trials using MSCs for the treatment of neurological disorders have been conducted, and results regarding their feasibility and efficacy have been reported. The present review aims to highlight the characteristics and basic research regarding the role of MSCs in neurological disease and to discuss the recent progress in clinical trials using MSCs to treat various neurological disorders. MDPI 2021-07-27 /pmc/articles/PMC8401282/ /pubmed/34452120 http://dx.doi.org/10.3390/pharmaceutics13081159 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mukai, Takeo
Sei, Kenshi
Nagamura-Inoue, Tokiko
Mesenchymal Stromal Cells Perspective: New Potential Therapeutic for the Treatment of Neurological Diseases
title Mesenchymal Stromal Cells Perspective: New Potential Therapeutic for the Treatment of Neurological Diseases
title_full Mesenchymal Stromal Cells Perspective: New Potential Therapeutic for the Treatment of Neurological Diseases
title_fullStr Mesenchymal Stromal Cells Perspective: New Potential Therapeutic for the Treatment of Neurological Diseases
title_full_unstemmed Mesenchymal Stromal Cells Perspective: New Potential Therapeutic for the Treatment of Neurological Diseases
title_short Mesenchymal Stromal Cells Perspective: New Potential Therapeutic for the Treatment of Neurological Diseases
title_sort mesenchymal stromal cells perspective: new potential therapeutic for the treatment of neurological diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401282/
https://www.ncbi.nlm.nih.gov/pubmed/34452120
http://dx.doi.org/10.3390/pharmaceutics13081159
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