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Evaluation of an Intravitreal Rho-Associated Kinase Inhibitor Depot Formulation in a Rat Model of Diabetic Retinopathy

Rho-associated kinase (ROCK) activation was shown to contribute to microvascular closure, retinal hypoxia, and to retinal pigment epithelium (RPE) barrier disruption in a rat model of diabetic retinopathy. Fasudil, a clinically approved ROCK inhibitor, improved retinal perfusion and reduced edema in...

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Detalles Bibliográficos
Autores principales:	Lebon, Cecile, Neubauer, Heike, Berdugo, Marianne, Delaunay, Kimberley, Markert, Elke, Becker, Kolja, Baum-Kroker, Katja S., Prestle, Jürgen, Fuchs, Holger, Bakker, Remko A., Behar-Cohen, Francine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401380/ https://www.ncbi.nlm.nih.gov/pubmed/34452066 http://dx.doi.org/10.3390/pharmaceutics13081105

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