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Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?

Cyclodextrins (CDs) are oligosaccharides widely used in the pharmaceutical field. In this review, a detailed examination of the literature of the last two decades has been made to understand the role of CDs in nasal drug delivery systems. In nasal formulations, CDs are used as pharmaceutical excipie...

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Autores principales: Rassu, Giovanna, Sorrenti, Milena, Catenacci, Laura, Pavan, Barbara, Ferraro, Luca, Gavini, Elisabetta, Bonferoni, Maria Cristina, Giunchedi, Paolo, Dalpiaz, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401481/
https://www.ncbi.nlm.nih.gov/pubmed/34452141
http://dx.doi.org/10.3390/pharmaceutics13081180
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author Rassu, Giovanna
Sorrenti, Milena
Catenacci, Laura
Pavan, Barbara
Ferraro, Luca
Gavini, Elisabetta
Bonferoni, Maria Cristina
Giunchedi, Paolo
Dalpiaz, Alessandro
author_facet Rassu, Giovanna
Sorrenti, Milena
Catenacci, Laura
Pavan, Barbara
Ferraro, Luca
Gavini, Elisabetta
Bonferoni, Maria Cristina
Giunchedi, Paolo
Dalpiaz, Alessandro
author_sort Rassu, Giovanna
collection PubMed
description Cyclodextrins (CDs) are oligosaccharides widely used in the pharmaceutical field. In this review, a detailed examination of the literature of the last two decades has been made to understand the role of CDs in nasal drug delivery systems. In nasal formulations, CDs are used as pharmaceutical excipients, as solubilizers and absorption promoters, and as active ingredients due to their several biological activities (antiviral, antiparasitic, anti-atherosclerotic, and neuroprotective). The use of CDs in nasal formulations allowed obtaining versatile drug delivery systems intended for local and systemic effects, as well as for nose-to-brain transport of drugs. In vitro and in vivo models currently employed are suitable to analyze the effects of CDs in nasal formulations. Therefore, CDs are versatile pharmaceutical materials, and due to the continual synthesis of new CDs derivatives, the research on the new nasal applications is an interesting field evolving in the coming years, to which Italian research will still contribute.
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spelling pubmed-84014812021-08-29 Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives? Rassu, Giovanna Sorrenti, Milena Catenacci, Laura Pavan, Barbara Ferraro, Luca Gavini, Elisabetta Bonferoni, Maria Cristina Giunchedi, Paolo Dalpiaz, Alessandro Pharmaceutics Review Cyclodextrins (CDs) are oligosaccharides widely used in the pharmaceutical field. In this review, a detailed examination of the literature of the last two decades has been made to understand the role of CDs in nasal drug delivery systems. In nasal formulations, CDs are used as pharmaceutical excipients, as solubilizers and absorption promoters, and as active ingredients due to their several biological activities (antiviral, antiparasitic, anti-atherosclerotic, and neuroprotective). The use of CDs in nasal formulations allowed obtaining versatile drug delivery systems intended for local and systemic effects, as well as for nose-to-brain transport of drugs. In vitro and in vivo models currently employed are suitable to analyze the effects of CDs in nasal formulations. Therefore, CDs are versatile pharmaceutical materials, and due to the continual synthesis of new CDs derivatives, the research on the new nasal applications is an interesting field evolving in the coming years, to which Italian research will still contribute. MDPI 2021-07-30 /pmc/articles/PMC8401481/ /pubmed/34452141 http://dx.doi.org/10.3390/pharmaceutics13081180 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rassu, Giovanna
Sorrenti, Milena
Catenacci, Laura
Pavan, Barbara
Ferraro, Luca
Gavini, Elisabetta
Bonferoni, Maria Cristina
Giunchedi, Paolo
Dalpiaz, Alessandro
Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?
title Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?
title_full Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?
title_fullStr Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?
title_full_unstemmed Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?
title_short Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?
title_sort versatile nasal application of cyclodextrins: excipients and/or actives?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401481/
https://www.ncbi.nlm.nih.gov/pubmed/34452141
http://dx.doi.org/10.3390/pharmaceutics13081180
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