Cargando…
Sclerosing Extramedullary Hematopoietic Tumor (SEHT) Mimicking a Malignant Bile Duct Tumor-Case Report and Literature Review
Introduction: Sclerosing Extramedullary Hematopoietic Tumor (SEHT) is a very rare lesion associated with chronic myeloproliferative disorders (CMPD). SEHT can mimic morphologically, both macroscopically and microscopically, a wide variety of tumors/lesions. Case presentation: We present the case of...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401495/ https://www.ncbi.nlm.nih.gov/pubmed/34441030 http://dx.doi.org/10.3390/medicina57080824 |
_version_ | 1783745564462022656 |
---|---|
author | Dema, Sorin Lazar, Fulger Barna, Robert Dobrescu, Amadeus Dema, Alis Liliana Carmen Popa, Oana Ionita, Ioana Taban, Sorina Maria |
author_facet | Dema, Sorin Lazar, Fulger Barna, Robert Dobrescu, Amadeus Dema, Alis Liliana Carmen Popa, Oana Ionita, Ioana Taban, Sorina Maria |
author_sort | Dema, Sorin |
collection | PubMed |
description | Introduction: Sclerosing Extramedullary Hematopoietic Tumor (SEHT) is a very rare lesion associated with chronic myeloproliferative disorders (CMPD). SEHT can mimic morphologically, both macroscopically and microscopically, a wide variety of tumors/lesions. Case presentation: We present the case of a female patient diagnosed with gallstones for which surgery was decided. Intraoperatively, a malignant tumor of extrahepatic bile ducts was suspected. A frozen section examination raised the suspicion of a mesenchymal tumor or an inflammatory pseudotumor. The histological evaluation of the permanent sections, supplemented with an immunohistochemical investigation (IHC), was the one that established the diagnosis of SEHT, based on the presence of areas of sclerosis, atypical CD31+ megakaryocytes, myeloid and erythroid elements. Conclusions: The authors present the difficulties of a morphological diagnosis on the frozen section and on permanent sections in the absence of relevant clinical information and make a review of the literature data dedicated to the subject. |
format | Online Article Text |
id | pubmed-8401495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84014952021-08-29 Sclerosing Extramedullary Hematopoietic Tumor (SEHT) Mimicking a Malignant Bile Duct Tumor-Case Report and Literature Review Dema, Sorin Lazar, Fulger Barna, Robert Dobrescu, Amadeus Dema, Alis Liliana Carmen Popa, Oana Ionita, Ioana Taban, Sorina Maria Medicina (Kaunas) Case Report Introduction: Sclerosing Extramedullary Hematopoietic Tumor (SEHT) is a very rare lesion associated with chronic myeloproliferative disorders (CMPD). SEHT can mimic morphologically, both macroscopically and microscopically, a wide variety of tumors/lesions. Case presentation: We present the case of a female patient diagnosed with gallstones for which surgery was decided. Intraoperatively, a malignant tumor of extrahepatic bile ducts was suspected. A frozen section examination raised the suspicion of a mesenchymal tumor or an inflammatory pseudotumor. The histological evaluation of the permanent sections, supplemented with an immunohistochemical investigation (IHC), was the one that established the diagnosis of SEHT, based on the presence of areas of sclerosis, atypical CD31+ megakaryocytes, myeloid and erythroid elements. Conclusions: The authors present the difficulties of a morphological diagnosis on the frozen section and on permanent sections in the absence of relevant clinical information and make a review of the literature data dedicated to the subject. MDPI 2021-08-16 /pmc/articles/PMC8401495/ /pubmed/34441030 http://dx.doi.org/10.3390/medicina57080824 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Dema, Sorin Lazar, Fulger Barna, Robert Dobrescu, Amadeus Dema, Alis Liliana Carmen Popa, Oana Ionita, Ioana Taban, Sorina Maria Sclerosing Extramedullary Hematopoietic Tumor (SEHT) Mimicking a Malignant Bile Duct Tumor-Case Report and Literature Review |
title | Sclerosing Extramedullary Hematopoietic Tumor (SEHT) Mimicking a Malignant Bile Duct Tumor-Case Report and Literature Review |
title_full | Sclerosing Extramedullary Hematopoietic Tumor (SEHT) Mimicking a Malignant Bile Duct Tumor-Case Report and Literature Review |
title_fullStr | Sclerosing Extramedullary Hematopoietic Tumor (SEHT) Mimicking a Malignant Bile Duct Tumor-Case Report and Literature Review |
title_full_unstemmed | Sclerosing Extramedullary Hematopoietic Tumor (SEHT) Mimicking a Malignant Bile Duct Tumor-Case Report and Literature Review |
title_short | Sclerosing Extramedullary Hematopoietic Tumor (SEHT) Mimicking a Malignant Bile Duct Tumor-Case Report and Literature Review |
title_sort | sclerosing extramedullary hematopoietic tumor (seht) mimicking a malignant bile duct tumor-case report and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401495/ https://www.ncbi.nlm.nih.gov/pubmed/34441030 http://dx.doi.org/10.3390/medicina57080824 |
work_keys_str_mv | AT demasorin sclerosingextramedullaryhematopoietictumorsehtmimickingamalignantbileducttumorcasereportandliteraturereview AT lazarfulger sclerosingextramedullaryhematopoietictumorsehtmimickingamalignantbileducttumorcasereportandliteraturereview AT barnarobert sclerosingextramedullaryhematopoietictumorsehtmimickingamalignantbileducttumorcasereportandliteraturereview AT dobrescuamadeus sclerosingextramedullaryhematopoietictumorsehtmimickingamalignantbileducttumorcasereportandliteraturereview AT demaalislilianacarmen sclerosingextramedullaryhematopoietictumorsehtmimickingamalignantbileducttumorcasereportandliteraturereview AT popaoana sclerosingextramedullaryhematopoietictumorsehtmimickingamalignantbileducttumorcasereportandliteraturereview AT ionitaioana sclerosingextramedullaryhematopoietictumorsehtmimickingamalignantbileducttumorcasereportandliteraturereview AT tabansorinamaria sclerosingextramedullaryhematopoietictumorsehtmimickingamalignantbileducttumorcasereportandliteraturereview |