Cargando…

Low Preoperative Antithrombin III Level Is Associated with Postoperative Acute Kidney Injury after Liver Transplantation

We aimed to determine the association between the preoperative antithrombin III (ATIII) level and postoperative acute kidney injury (AKI) after LT (post-LT AKI). We retrospectively evaluated 2395 LT recipients between 2010 and 2018 whose data of perioperative ATIII levels were available. Patients we...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Kyoung-Sun, Moon, Young-Jin, Kim, Sung-Hoon, Kim, Bomi, Jun, In-Gu, Kwon, Hye-Mee, Song, Jun-Gol, Hwang, Gyu-Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401622/
https://www.ncbi.nlm.nih.gov/pubmed/34442360
http://dx.doi.org/10.3390/jpm11080716
_version_ 1783745594649477120
author Kim, Kyoung-Sun
Moon, Young-Jin
Kim, Sung-Hoon
Kim, Bomi
Jun, In-Gu
Kwon, Hye-Mee
Song, Jun-Gol
Hwang, Gyu-Sam
author_facet Kim, Kyoung-Sun
Moon, Young-Jin
Kim, Sung-Hoon
Kim, Bomi
Jun, In-Gu
Kwon, Hye-Mee
Song, Jun-Gol
Hwang, Gyu-Sam
author_sort Kim, Kyoung-Sun
collection PubMed
description We aimed to determine the association between the preoperative antithrombin III (ATIII) level and postoperative acute kidney injury (AKI) after LT (post-LT AKI). We retrospectively evaluated 2395 LT recipients between 2010 and 2018 whose data of perioperative ATIII levels were available. Patients were divided into two groups based on the preoperative level of ATIII (ATIII < 50% vs. ATIII ≥ 50%). Multivariable regression analysis was performed to assess the risk factors for post-LT AKI. The mean preoperative ATIII levels were 30.2 ± 11.8% in the ATIII < 50% group and 67.2 ± 13.2% in the ATIII ≥ 50% group. The incidence of post-LT AKI was significantly lower in the ATIII ≥ 50% group compared to that in the ATIII < 50% group (54.7% vs. 75.5%, p < 0.001); odds ratio (OR, per 10% increase in ATIII level) 0.86, 95% confidence interval (CI) 0.81–0.92; p < 0.001. After a backward stepwise regression model, female sex, high body mass index, low albumin, deceased donor LT, longer duration of surgery, and high red blood cell transfusion remained significantly associated with post-LT AKI. A low preoperative ATIII level is associated with post-LT AKI, suggesting that preoperative ATIII might be a prognostic factor for predicting post-LT AKI.
format Online
Article
Text
id pubmed-8401622
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84016222021-08-29 Low Preoperative Antithrombin III Level Is Associated with Postoperative Acute Kidney Injury after Liver Transplantation Kim, Kyoung-Sun Moon, Young-Jin Kim, Sung-Hoon Kim, Bomi Jun, In-Gu Kwon, Hye-Mee Song, Jun-Gol Hwang, Gyu-Sam J Pers Med Article We aimed to determine the association between the preoperative antithrombin III (ATIII) level and postoperative acute kidney injury (AKI) after LT (post-LT AKI). We retrospectively evaluated 2395 LT recipients between 2010 and 2018 whose data of perioperative ATIII levels were available. Patients were divided into two groups based on the preoperative level of ATIII (ATIII < 50% vs. ATIII ≥ 50%). Multivariable regression analysis was performed to assess the risk factors for post-LT AKI. The mean preoperative ATIII levels were 30.2 ± 11.8% in the ATIII < 50% group and 67.2 ± 13.2% in the ATIII ≥ 50% group. The incidence of post-LT AKI was significantly lower in the ATIII ≥ 50% group compared to that in the ATIII < 50% group (54.7% vs. 75.5%, p < 0.001); odds ratio (OR, per 10% increase in ATIII level) 0.86, 95% confidence interval (CI) 0.81–0.92; p < 0.001. After a backward stepwise regression model, female sex, high body mass index, low albumin, deceased donor LT, longer duration of surgery, and high red blood cell transfusion remained significantly associated with post-LT AKI. A low preoperative ATIII level is associated with post-LT AKI, suggesting that preoperative ATIII might be a prognostic factor for predicting post-LT AKI. MDPI 2021-07-26 /pmc/articles/PMC8401622/ /pubmed/34442360 http://dx.doi.org/10.3390/jpm11080716 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Kyoung-Sun
Moon, Young-Jin
Kim, Sung-Hoon
Kim, Bomi
Jun, In-Gu
Kwon, Hye-Mee
Song, Jun-Gol
Hwang, Gyu-Sam
Low Preoperative Antithrombin III Level Is Associated with Postoperative Acute Kidney Injury after Liver Transplantation
title Low Preoperative Antithrombin III Level Is Associated with Postoperative Acute Kidney Injury after Liver Transplantation
title_full Low Preoperative Antithrombin III Level Is Associated with Postoperative Acute Kidney Injury after Liver Transplantation
title_fullStr Low Preoperative Antithrombin III Level Is Associated with Postoperative Acute Kidney Injury after Liver Transplantation
title_full_unstemmed Low Preoperative Antithrombin III Level Is Associated with Postoperative Acute Kidney Injury after Liver Transplantation
title_short Low Preoperative Antithrombin III Level Is Associated with Postoperative Acute Kidney Injury after Liver Transplantation
title_sort low preoperative antithrombin iii level is associated with postoperative acute kidney injury after liver transplantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401622/
https://www.ncbi.nlm.nih.gov/pubmed/34442360
http://dx.doi.org/10.3390/jpm11080716
work_keys_str_mv AT kimkyoungsun lowpreoperativeantithrombiniiilevelisassociatedwithpostoperativeacutekidneyinjuryafterlivertransplantation
AT moonyoungjin lowpreoperativeantithrombiniiilevelisassociatedwithpostoperativeacutekidneyinjuryafterlivertransplantation
AT kimsunghoon lowpreoperativeantithrombiniiilevelisassociatedwithpostoperativeacutekidneyinjuryafterlivertransplantation
AT kimbomi lowpreoperativeantithrombiniiilevelisassociatedwithpostoperativeacutekidneyinjuryafterlivertransplantation
AT juningu lowpreoperativeantithrombiniiilevelisassociatedwithpostoperativeacutekidneyinjuryafterlivertransplantation
AT kwonhyemee lowpreoperativeantithrombiniiilevelisassociatedwithpostoperativeacutekidneyinjuryafterlivertransplantation
AT songjungol lowpreoperativeantithrombiniiilevelisassociatedwithpostoperativeacutekidneyinjuryafterlivertransplantation
AT hwanggyusam lowpreoperativeantithrombiniiilevelisassociatedwithpostoperativeacutekidneyinjuryafterlivertransplantation