New 2,3-Benzodiazepine Derivative: Synthesis, Activity on Central Nervous System, and Toxicity Study in Mice

We report the design and synthesis of a new diazepine derivative, 4-(4-methoxyphenyl)-2,3,4,5-tetrahydro-2,3-benzodiazepin-1-one (VBZ102), and the evaluation of its anxiolytic-like profile, memory impairment effect, and toxicity in Swiss mice. VBZ102 was evaluated for central nervous system effects...

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Detalles Bibliográficos
Autores principales: Amaghnouje, Amal, Bohza, Serhii, Bohdan, Nathalie, Es-Safi, Imane, Kyrylchuk, Andrii, Achour, Sanae, El Fatemi, Hinde, Bousta, Dalila, Grafov, Andriy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401732/
https://www.ncbi.nlm.nih.gov/pubmed/34451911
http://dx.doi.org/10.3390/ph14080814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401732/
https://www.ncbi.nlm.nih.gov/pubmed/34451911
http://dx.doi.org/10.3390/ph14080814

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