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Zebrafish as an Animal Model for Testing Agents with Antidepressant Potential

Depression is a serious mental disease that, according to statistics, affects 320 million people worldwide. Additionally, a current situation related to the COVID-19 pandemic has led to a significant deterioration of mental health in people around the world. So far, rodents have been treated as basi...

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Detalles Bibliográficos
Autores principales: Lachowicz, Joanna, Niedziałek, Karolina, Rostkowska, Ewelina, Szopa, Aleksandra, Świąder, Katarzyna, Szponar, Jarosław, Serefko, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401799/
https://www.ncbi.nlm.nih.gov/pubmed/34440536
http://dx.doi.org/10.3390/life11080792
Descripción
Sumario:Depression is a serious mental disease that, according to statistics, affects 320 million people worldwide. Additionally, a current situation related to the COVID-19 pandemic has led to a significant deterioration of mental health in people around the world. So far, rodents have been treated as basic animal models used in studies on this disease, but in recent years, Danio rerio has emerged as a new organism that might serve well in preclinical experiments. Zebrafish have a lot of advantages, such as a quick reproductive cycle, transparent body during the early developmental stages, high genetic and physiological homology to humans, and low costs of maintenance. Here, we discuss the potential of the zebrafish model to be used in behavioral studies focused on testing agents with antidepressant potential.