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Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier
The prospective strategy for treatment of cancer is based on the application of nano-sized macromolecular carriers, which are able penetrate inside and can be accumulated within tumor tissue. In this work graft copolymers of cellulose and poly(methacrylic acid) has been prepared and tested as a nano...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401802/ https://www.ncbi.nlm.nih.gov/pubmed/34443825 http://dx.doi.org/10.3390/nano11081997 |
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author | Krasnopeeva, Elena L. Melenevskaya, Elena Yu. Klapshina, Larisa G. Shilyagina, Natalia Yu. Balalaeva, Irina V. Smirnov, Nikolay N. Smirnov, Michael A. Yakimansky, Alexander V. |
author_facet | Krasnopeeva, Elena L. Melenevskaya, Elena Yu. Klapshina, Larisa G. Shilyagina, Natalia Yu. Balalaeva, Irina V. Smirnov, Nikolay N. Smirnov, Michael A. Yakimansky, Alexander V. |
author_sort | Krasnopeeva, Elena L. |
collection | PubMed |
description | The prospective strategy for treatment of cancer is based on the application of nano-sized macromolecular carriers, which are able penetrate inside and can be accumulated within tumor tissue. In this work graft copolymers of cellulose and poly(methacrylic acid) has been prepared and tested as a nanocontainers for the delivery of drug to tumor. For this purpose, two derivatives of porphyrazine suitable for photodynamic cancer therapy were loaded into prepared polymer brush. Fluorescence imaging was applied for monitoring of accumulation of porphyrazine in the CT26 murine colon carcinoma. The selective accumulation of cellulose brush loaded with porphyrazine in tumor was demonstrated by fluorescence intensity contrast between the tumor area and normal tissues. The tumor growth rate after photodynamic therapy were assessed and inhibition of its growth was revealed. |
format | Online Article Text |
id | pubmed-8401802 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84018022021-08-29 Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier Krasnopeeva, Elena L. Melenevskaya, Elena Yu. Klapshina, Larisa G. Shilyagina, Natalia Yu. Balalaeva, Irina V. Smirnov, Nikolay N. Smirnov, Michael A. Yakimansky, Alexander V. Nanomaterials (Basel) Article The prospective strategy for treatment of cancer is based on the application of nano-sized macromolecular carriers, which are able penetrate inside and can be accumulated within tumor tissue. In this work graft copolymers of cellulose and poly(methacrylic acid) has been prepared and tested as a nanocontainers for the delivery of drug to tumor. For this purpose, two derivatives of porphyrazine suitable for photodynamic cancer therapy were loaded into prepared polymer brush. Fluorescence imaging was applied for monitoring of accumulation of porphyrazine in the CT26 murine colon carcinoma. The selective accumulation of cellulose brush loaded with porphyrazine in tumor was demonstrated by fluorescence intensity contrast between the tumor area and normal tissues. The tumor growth rate after photodynamic therapy were assessed and inhibition of its growth was revealed. MDPI 2021-08-03 /pmc/articles/PMC8401802/ /pubmed/34443825 http://dx.doi.org/10.3390/nano11081997 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Krasnopeeva, Elena L. Melenevskaya, Elena Yu. Klapshina, Larisa G. Shilyagina, Natalia Yu. Balalaeva, Irina V. Smirnov, Nikolay N. Smirnov, Michael A. Yakimansky, Alexander V. Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier |
title | Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier |
title_full | Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier |
title_fullStr | Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier |
title_full_unstemmed | Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier |
title_short | Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier |
title_sort | poly(methacrylic acid)-cellulose brushes as anticancer porphyrazine carrier |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401802/ https://www.ncbi.nlm.nih.gov/pubmed/34443825 http://dx.doi.org/10.3390/nano11081997 |
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