Influence of MXene Particles with a Stacked-Lamellar Structure on Osteogenic Differentiation of Human Mesenchymal Stem Cells

MXenes with a two-dimensional (2D) structure have attracted attention as potential biomedical materials. In this study, Ti(3)C(2) MXene particles with 2D-lamellar structures were intercalated and their potential as a biomaterial was evaluated using human mesenchymal stem cells. Intercalated MXene wa...

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Detalles Bibliográficos
Autores principales: Jang, Jun-Hwee, Lee, Eun-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401813/
https://www.ncbi.nlm.nih.gov/pubmed/34442976
http://dx.doi.org/10.3390/ma14164453
Descripción
Sumario:MXenes with a two-dimensional (2D) structure have attracted attention as potential biomedical materials. In this study, Ti(3)C(2) MXene particles with 2D-lamellar structures were intercalated and their potential as a biomaterial was evaluated using human mesenchymal stem cells. Intercalated MXene was characterized in terms of microstructure, phase composition, and size. Cell proliferation experiments with MXene particles confirmed that concentrations >50 μg/mL were cytotoxic, while concentrations <20 μg/mL promoted osteogenic differentiation. Moreover, MXene effectively facilitated the early and late osteogenic gene expression.

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