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Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study

Collagen and its peptides are natural ingredients used in food supplements and nutricosmetics with the claim of providing benefits for skin health and beauty. In this context, the aim of the present study was to evaluate the clinical efficacy of oral supplementation with hydrolyzed fish cartilage fo...

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Autores principales: Maia Campos, Patrícia Maria Berardo Gonçalves, Franco, Rodolfo Scarpino Barboza, Kakuda, Letícia, Cadioli, Gabriel Fernandes, Costa, Gabriela Maria D’Angelo, Bouvret, Elodie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401832/
https://www.ncbi.nlm.nih.gov/pubmed/34443468
http://dx.doi.org/10.3390/molecules26164880
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author Maia Campos, Patrícia Maria Berardo Gonçalves
Franco, Rodolfo Scarpino Barboza
Kakuda, Letícia
Cadioli, Gabriel Fernandes
Costa, Gabriela Maria D’Angelo
Bouvret, Elodie
author_facet Maia Campos, Patrícia Maria Berardo Gonçalves
Franco, Rodolfo Scarpino Barboza
Kakuda, Letícia
Cadioli, Gabriel Fernandes
Costa, Gabriela Maria D’Angelo
Bouvret, Elodie
author_sort Maia Campos, Patrícia Maria Berardo Gonçalves
collection PubMed
description Collagen and its peptides are natural ingredients used in food supplements and nutricosmetics with the claim of providing benefits for skin health and beauty. In this context, the aim of the present study was to evaluate the clinical efficacy of oral supplementation with hydrolyzed fish cartilage for the improvement of chronological and photoaging-induced skin changes. A total of 46 healthy females aged 45 to 59 years were enrolled and divided into two groups: G1—placebo and G2—oral treatment with hydrolyzed fish cartilage. Measurements of skin wrinkles, dermis echogenicity and thickness, and morphological and structural characteristics of the skin were performed in the nasolabial region of the face before and after a 90-day period of treatment using high-resolution imaging, ultrasound, and reflectance confocal microscopy image analyses. A significant reduction in wrinkles and an increase of dermis echogenicity were observed after a 90-day period of treatment with hydrolyzed fish cartilage compared to the placebo and baseline values. In addition, reflectance confocal microscopy (RCM) image analysis showed improved collagen morphology and reduced elastosis after treatment with hydrolyzed fish cartilage. The present study showed the clinical benefits for the skin obtained with oral supplementation with a low dose of collagen peptides from hydrolyzed fish cartilage.
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spelling pubmed-84018322021-08-29 Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study Maia Campos, Patrícia Maria Berardo Gonçalves Franco, Rodolfo Scarpino Barboza Kakuda, Letícia Cadioli, Gabriel Fernandes Costa, Gabriela Maria D’Angelo Bouvret, Elodie Molecules Article Collagen and its peptides are natural ingredients used in food supplements and nutricosmetics with the claim of providing benefits for skin health and beauty. In this context, the aim of the present study was to evaluate the clinical efficacy of oral supplementation with hydrolyzed fish cartilage for the improvement of chronological and photoaging-induced skin changes. A total of 46 healthy females aged 45 to 59 years were enrolled and divided into two groups: G1—placebo and G2—oral treatment with hydrolyzed fish cartilage. Measurements of skin wrinkles, dermis echogenicity and thickness, and morphological and structural characteristics of the skin were performed in the nasolabial region of the face before and after a 90-day period of treatment using high-resolution imaging, ultrasound, and reflectance confocal microscopy image analyses. A significant reduction in wrinkles and an increase of dermis echogenicity were observed after a 90-day period of treatment with hydrolyzed fish cartilage compared to the placebo and baseline values. In addition, reflectance confocal microscopy (RCM) image analysis showed improved collagen morphology and reduced elastosis after treatment with hydrolyzed fish cartilage. The present study showed the clinical benefits for the skin obtained with oral supplementation with a low dose of collagen peptides from hydrolyzed fish cartilage. MDPI 2021-08-12 /pmc/articles/PMC8401832/ /pubmed/34443468 http://dx.doi.org/10.3390/molecules26164880 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Maia Campos, Patrícia Maria Berardo Gonçalves
Franco, Rodolfo Scarpino Barboza
Kakuda, Letícia
Cadioli, Gabriel Fernandes
Costa, Gabriela Maria D’Angelo
Bouvret, Elodie
Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study
title Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study
title_full Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study
title_fullStr Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study
title_full_unstemmed Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study
title_short Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study
title_sort oral supplementation with hydrolyzed fish cartilage improves the morphological and structural characteristics of the skin: a double-blind, placebo-controlled clinical study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401832/
https://www.ncbi.nlm.nih.gov/pubmed/34443468
http://dx.doi.org/10.3390/molecules26164880
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