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Cunninghamella arunalokei a New Species of Cunninghamella from India Causing Disease in an Immunocompetent Individual
Mucormycosis due to Cunninghamella spp. is a rare disease, especially in immunocompetent individuals. Here, we describe the isolation and characterization of a new species of Cunninghamella, causing chronic rhino-orbital-cerebral disease, and review cases of mucormycosis due to Cunninghamella spp. i...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401845/ https://www.ncbi.nlm.nih.gov/pubmed/34436209 http://dx.doi.org/10.3390/jof7080670 |
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author | Hallur, Vinaykumar Prakash, Hariprasath Sable, Mukund Preetam, Chappity Purushotham, Prashanth Senapati, Rabindra Shankarnarayan, Shamanth Adekhandi Bag, Nerbadyswari Deep Rudramurthy, Shivaprakash Mandya |
author_facet | Hallur, Vinaykumar Prakash, Hariprasath Sable, Mukund Preetam, Chappity Purushotham, Prashanth Senapati, Rabindra Shankarnarayan, Shamanth Adekhandi Bag, Nerbadyswari Deep Rudramurthy, Shivaprakash Mandya |
author_sort | Hallur, Vinaykumar |
collection | PubMed |
description | Mucormycosis due to Cunninghamella spp. is a rare disease, especially in immunocompetent individuals. Here, we describe the isolation and characterization of a new species of Cunninghamella, causing chronic rhino-orbital-cerebral disease, and review cases of mucormycosis due to Cunninghamella spp. in immunocompetent individuals. The Basic Local Alignment Search Tool (BLAST) analysis of the internal transcribed spacer region (ITS) sequence of isolate NCCPF 890012 showed 90% similarity with Cunninghamella bigelovii, while the large ribosomal subunit (28S) and translation elongation factor-1 alpha (EF-1 alpha) gene sequences showed 98% identity. Further, the phylogenetic analysis with concatenated sequences clustered isolate (NCCPF 890012) closely with C. bigelovii. The ITS sequence showed the maximum variation among three genes analyzed and helped in the new species’ delineation. Comparison of the assembled whole genome of NCCPF 890012 with other Mucorales using 123 single-copy orthologous genes showed clustering within the genus Cunninghamella. Based on these findings, the isolate is considered to be a new species of Cunninghamella and designated as Cunninghamella arunalokei sp. nov. Despite repeated debridement and antifungal treatment, the patient had multiple recurrences with intracranial extension and succumbed to the illness. |
format | Online Article Text |
id | pubmed-8401845 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84018452021-08-29 Cunninghamella arunalokei a New Species of Cunninghamella from India Causing Disease in an Immunocompetent Individual Hallur, Vinaykumar Prakash, Hariprasath Sable, Mukund Preetam, Chappity Purushotham, Prashanth Senapati, Rabindra Shankarnarayan, Shamanth Adekhandi Bag, Nerbadyswari Deep Rudramurthy, Shivaprakash Mandya J Fungi (Basel) Article Mucormycosis due to Cunninghamella spp. is a rare disease, especially in immunocompetent individuals. Here, we describe the isolation and characterization of a new species of Cunninghamella, causing chronic rhino-orbital-cerebral disease, and review cases of mucormycosis due to Cunninghamella spp. in immunocompetent individuals. The Basic Local Alignment Search Tool (BLAST) analysis of the internal transcribed spacer region (ITS) sequence of isolate NCCPF 890012 showed 90% similarity with Cunninghamella bigelovii, while the large ribosomal subunit (28S) and translation elongation factor-1 alpha (EF-1 alpha) gene sequences showed 98% identity. Further, the phylogenetic analysis with concatenated sequences clustered isolate (NCCPF 890012) closely with C. bigelovii. The ITS sequence showed the maximum variation among three genes analyzed and helped in the new species’ delineation. Comparison of the assembled whole genome of NCCPF 890012 with other Mucorales using 123 single-copy orthologous genes showed clustering within the genus Cunninghamella. Based on these findings, the isolate is considered to be a new species of Cunninghamella and designated as Cunninghamella arunalokei sp. nov. Despite repeated debridement and antifungal treatment, the patient had multiple recurrences with intracranial extension and succumbed to the illness. MDPI 2021-08-19 /pmc/articles/PMC8401845/ /pubmed/34436209 http://dx.doi.org/10.3390/jof7080670 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hallur, Vinaykumar Prakash, Hariprasath Sable, Mukund Preetam, Chappity Purushotham, Prashanth Senapati, Rabindra Shankarnarayan, Shamanth Adekhandi Bag, Nerbadyswari Deep Rudramurthy, Shivaprakash Mandya Cunninghamella arunalokei a New Species of Cunninghamella from India Causing Disease in an Immunocompetent Individual |
title | Cunninghamella arunalokei a New Species of Cunninghamella from India Causing Disease in an Immunocompetent Individual |
title_full | Cunninghamella arunalokei a New Species of Cunninghamella from India Causing Disease in an Immunocompetent Individual |
title_fullStr | Cunninghamella arunalokei a New Species of Cunninghamella from India Causing Disease in an Immunocompetent Individual |
title_full_unstemmed | Cunninghamella arunalokei a New Species of Cunninghamella from India Causing Disease in an Immunocompetent Individual |
title_short | Cunninghamella arunalokei a New Species of Cunninghamella from India Causing Disease in an Immunocompetent Individual |
title_sort | cunninghamella arunalokei a new species of cunninghamella from india causing disease in an immunocompetent individual |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401845/ https://www.ncbi.nlm.nih.gov/pubmed/34436209 http://dx.doi.org/10.3390/jof7080670 |
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