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Stipa tenacissima L.: A New Promising Source of Bioactive Compounds with Antioxidant and Anticancer Potentials

Background: Stipa tenacissima L. (S. tenacissima), called Esparto grass, is a cultivated species used for industrial purposes, including textile production. This species has never been studied for its medical potential before, nor has it been used in traditional medicines. It is thus fitting that th...

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Autores principales: El Bouchti, Mehdi, Bourhia, Mohammed, Alotaibi, Amal, Aghmih, Kaoutar, Majid, Sanaa, Ullah, Riaz, Salamatullah, Ahmad Mohammad, El Achaby, Mounir, Oumam, Mina, Hannache, Hassan, Cherkaoui, Omar, El Mzibri, Mohammed, Benbacer, Laila, Gmouh, Said
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401904/
https://www.ncbi.nlm.nih.gov/pubmed/34440501
http://dx.doi.org/10.3390/life11080757
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author El Bouchti, Mehdi
Bourhia, Mohammed
Alotaibi, Amal
Aghmih, Kaoutar
Majid, Sanaa
Ullah, Riaz
Salamatullah, Ahmad Mohammad
El Achaby, Mounir
Oumam, Mina
Hannache, Hassan
Cherkaoui, Omar
El Mzibri, Mohammed
Benbacer, Laila
Gmouh, Said
author_facet El Bouchti, Mehdi
Bourhia, Mohammed
Alotaibi, Amal
Aghmih, Kaoutar
Majid, Sanaa
Ullah, Riaz
Salamatullah, Ahmad Mohammad
El Achaby, Mounir
Oumam, Mina
Hannache, Hassan
Cherkaoui, Omar
El Mzibri, Mohammed
Benbacer, Laila
Gmouh, Said
author_sort El Bouchti, Mehdi
collection PubMed
description Background: Stipa tenacissima L. (S. tenacissima), called Esparto grass, is a cultivated species used for industrial purposes, including textile production. This species has never been studied for its medical potential before, nor has it been used in traditional medicines. It is thus fitting that the present study aimed to investigate the pharmacological potential of S. tenacissima. To achieve this goal, this work was conducted to study the chemical composition, antioxidant properties, and antiproliferative effects of S. tenacissima against cancerous cell lines, including the human colorectal adenocarcinoma cell line (HT-29) and human breast adenocarcinoma cell line (MDA-MB-231). Fractionation and characterization of S. tenacissima extract showed the presence of promising bioactive fractions. The fractions obtained from S. tenacissima extract exhibited interesting antioxidant properties, with IC(50) values ranging from 1.26 to 1.85 mg/mL. All fractions, such as F1, F2, F3, and F4, induced an important antiproliferative effect on the cancer cell lines MDA-MB-231, scoring IC(50) values ranging from 63.58 ± 3.14 to 99.880 ± 0.061 µg/mL. These fractions (F1, F2, F3, and F4) also exhibited a potent antiproliferative effect versus HT-29 cell lines, with IC(50) values ranging from 71.50 ± 4.97 to 87.500 ± 1.799 µg/mL. Therefore, S. tenacissima could constitute a new natural source of bioactive compounds that can be used for therapeutic purposes to fight cancer and free radical damage.
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spelling pubmed-84019042021-08-29 Stipa tenacissima L.: A New Promising Source of Bioactive Compounds with Antioxidant and Anticancer Potentials El Bouchti, Mehdi Bourhia, Mohammed Alotaibi, Amal Aghmih, Kaoutar Majid, Sanaa Ullah, Riaz Salamatullah, Ahmad Mohammad El Achaby, Mounir Oumam, Mina Hannache, Hassan Cherkaoui, Omar El Mzibri, Mohammed Benbacer, Laila Gmouh, Said Life (Basel) Article Background: Stipa tenacissima L. (S. tenacissima), called Esparto grass, is a cultivated species used for industrial purposes, including textile production. This species has never been studied for its medical potential before, nor has it been used in traditional medicines. It is thus fitting that the present study aimed to investigate the pharmacological potential of S. tenacissima. To achieve this goal, this work was conducted to study the chemical composition, antioxidant properties, and antiproliferative effects of S. tenacissima against cancerous cell lines, including the human colorectal adenocarcinoma cell line (HT-29) and human breast adenocarcinoma cell line (MDA-MB-231). Fractionation and characterization of S. tenacissima extract showed the presence of promising bioactive fractions. The fractions obtained from S. tenacissima extract exhibited interesting antioxidant properties, with IC(50) values ranging from 1.26 to 1.85 mg/mL. All fractions, such as F1, F2, F3, and F4, induced an important antiproliferative effect on the cancer cell lines MDA-MB-231, scoring IC(50) values ranging from 63.58 ± 3.14 to 99.880 ± 0.061 µg/mL. These fractions (F1, F2, F3, and F4) also exhibited a potent antiproliferative effect versus HT-29 cell lines, with IC(50) values ranging from 71.50 ± 4.97 to 87.500 ± 1.799 µg/mL. Therefore, S. tenacissima could constitute a new natural source of bioactive compounds that can be used for therapeutic purposes to fight cancer and free radical damage. MDPI 2021-07-27 /pmc/articles/PMC8401904/ /pubmed/34440501 http://dx.doi.org/10.3390/life11080757 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
El Bouchti, Mehdi
Bourhia, Mohammed
Alotaibi, Amal
Aghmih, Kaoutar
Majid, Sanaa
Ullah, Riaz
Salamatullah, Ahmad Mohammad
El Achaby, Mounir
Oumam, Mina
Hannache, Hassan
Cherkaoui, Omar
El Mzibri, Mohammed
Benbacer, Laila
Gmouh, Said
Stipa tenacissima L.: A New Promising Source of Bioactive Compounds with Antioxidant and Anticancer Potentials
title Stipa tenacissima L.: A New Promising Source of Bioactive Compounds with Antioxidant and Anticancer Potentials
title_full Stipa tenacissima L.: A New Promising Source of Bioactive Compounds with Antioxidant and Anticancer Potentials
title_fullStr Stipa tenacissima L.: A New Promising Source of Bioactive Compounds with Antioxidant and Anticancer Potentials
title_full_unstemmed Stipa tenacissima L.: A New Promising Source of Bioactive Compounds with Antioxidant and Anticancer Potentials
title_short Stipa tenacissima L.: A New Promising Source of Bioactive Compounds with Antioxidant and Anticancer Potentials
title_sort stipa tenacissima l.: a new promising source of bioactive compounds with antioxidant and anticancer potentials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401904/
https://www.ncbi.nlm.nih.gov/pubmed/34440501
http://dx.doi.org/10.3390/life11080757
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