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Improving the Solubility and Oral Bioavailability of a Novel Aromatic Aldehyde Antisickling Agent (PP10) for the Treatment of Sickle Cell Disease

Background: Aromatic aldehydes, with their ability to increase the oxygen affinity of sickle hemoglobin, have become important therapeutic agents for sickle cell disease (SCD). One such compound, voxelotor, was recently approved for SCD treatment. Methyl 6-((2-formyl-3-hydroxyphenoxy)methyl) picolin...

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Detalles Bibliográficos
Autores principales:	Ahmed, Tarek A., El-Say, Khalid M., Abd-Allah, Fathy I., Omar, Abdelsattar M., El-Araby, Moustafa E., Muhammad, Yosra A., Pagare, Piyusha P., Zhang, Yan, Mohmmad, Khadijah A., Abdulmalik, Osheiza, Safo, Martin K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401948/ https://www.ncbi.nlm.nih.gov/pubmed/34452107 http://dx.doi.org/10.3390/pharmaceutics13081148

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