Cargando…

Inflammation Markers in Adipose Tissue and Cardiovascular Risk Reduction by Pomegranate Juice in Obesity Induced by a Hypercaloric Diet in Wistar Rats

Pomegranate juice (Punica granatum) has been used since ancient times in traditional medicine (Unani Medicine, Ayurveda); its main compounds are anthocyanins and ellagic acid, which have anti-inflammatory, antioxidant, hepatoprotective, and cardiovascular health effects. The objective was to evaluat...

Descripción completa

Detalles Bibliográficos
Autores principales: Michicotl-Meneses, Maria Monica, Thompson-Bonilla, María del Rocío, Reyes-López, César A., García-Pérez, Blanca Estela, López-Tenorio, Itzel I., Ordaz-Pichardo, Cynthia, Jaramillo-Flores, María Eugenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402035/
https://www.ncbi.nlm.nih.gov/pubmed/34444736
http://dx.doi.org/10.3390/nu13082577
_version_ 1783745692322234368
author Michicotl-Meneses, Maria Monica
Thompson-Bonilla, María del Rocío
Reyes-López, César A.
García-Pérez, Blanca Estela
López-Tenorio, Itzel I.
Ordaz-Pichardo, Cynthia
Jaramillo-Flores, María Eugenia
author_facet Michicotl-Meneses, Maria Monica
Thompson-Bonilla, María del Rocío
Reyes-López, César A.
García-Pérez, Blanca Estela
López-Tenorio, Itzel I.
Ordaz-Pichardo, Cynthia
Jaramillo-Flores, María Eugenia
author_sort Michicotl-Meneses, Maria Monica
collection PubMed
description Pomegranate juice (Punica granatum) has been used since ancient times in traditional medicine (Unani Medicine, Ayurveda); its main compounds are anthocyanins and ellagic acid, which have anti-inflammatory, antioxidant, hepatoprotective, and cardiovascular health effects. The objective was to evaluate the effect of pomegranate juice on inflammation, blood pressure, and vascular and physiological markers associated with obesity induced by a high-fat diet in a murine model. The results show that pomegranate juice reduces the concentration of low-density lipoprotein cholesterol (cLDL) 39% and increases the concentration of high-density lipoprotein cholesterol (cHDL) by 27%, leading to a 12%–18% decrease in the risk of cardiovascular diseases (CVD). In addition to reducing blood pressure by 24%, it also had an antiatherogenic effect by decreasing sE-selectin levels by 42%. On the other hand, the juice significantly increased adiponectin levels in adipose tissue, decreased levels of inflammation markers (tumor necrosis factor-α (TNF-α), plasminogen activator inhibitor-1 (PAI-1), interleukin-17A (IL-17A), interleukin-6 (IL-6), interleukin-1β (IL-1β)), and inhibited the monocyte chemoattractant protein-1 (MCP-1). Pomegranate juice requires clinical studies to prove its immunoregulatory and therapeutic effects on cardiovascular and atherogenic risks.
format Online
Article
Text
id pubmed-8402035
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84020352021-08-29 Inflammation Markers in Adipose Tissue and Cardiovascular Risk Reduction by Pomegranate Juice in Obesity Induced by a Hypercaloric Diet in Wistar Rats Michicotl-Meneses, Maria Monica Thompson-Bonilla, María del Rocío Reyes-López, César A. García-Pérez, Blanca Estela López-Tenorio, Itzel I. Ordaz-Pichardo, Cynthia Jaramillo-Flores, María Eugenia Nutrients Article Pomegranate juice (Punica granatum) has been used since ancient times in traditional medicine (Unani Medicine, Ayurveda); its main compounds are anthocyanins and ellagic acid, which have anti-inflammatory, antioxidant, hepatoprotective, and cardiovascular health effects. The objective was to evaluate the effect of pomegranate juice on inflammation, blood pressure, and vascular and physiological markers associated with obesity induced by a high-fat diet in a murine model. The results show that pomegranate juice reduces the concentration of low-density lipoprotein cholesterol (cLDL) 39% and increases the concentration of high-density lipoprotein cholesterol (cHDL) by 27%, leading to a 12%–18% decrease in the risk of cardiovascular diseases (CVD). In addition to reducing blood pressure by 24%, it also had an antiatherogenic effect by decreasing sE-selectin levels by 42%. On the other hand, the juice significantly increased adiponectin levels in adipose tissue, decreased levels of inflammation markers (tumor necrosis factor-α (TNF-α), plasminogen activator inhibitor-1 (PAI-1), interleukin-17A (IL-17A), interleukin-6 (IL-6), interleukin-1β (IL-1β)), and inhibited the monocyte chemoattractant protein-1 (MCP-1). Pomegranate juice requires clinical studies to prove its immunoregulatory and therapeutic effects on cardiovascular and atherogenic risks. MDPI 2021-07-27 /pmc/articles/PMC8402035/ /pubmed/34444736 http://dx.doi.org/10.3390/nu13082577 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Michicotl-Meneses, Maria Monica
Thompson-Bonilla, María del Rocío
Reyes-López, César A.
García-Pérez, Blanca Estela
López-Tenorio, Itzel I.
Ordaz-Pichardo, Cynthia
Jaramillo-Flores, María Eugenia
Inflammation Markers in Adipose Tissue and Cardiovascular Risk Reduction by Pomegranate Juice in Obesity Induced by a Hypercaloric Diet in Wistar Rats
title Inflammation Markers in Adipose Tissue and Cardiovascular Risk Reduction by Pomegranate Juice in Obesity Induced by a Hypercaloric Diet in Wistar Rats
title_full Inflammation Markers in Adipose Tissue and Cardiovascular Risk Reduction by Pomegranate Juice in Obesity Induced by a Hypercaloric Diet in Wistar Rats
title_fullStr Inflammation Markers in Adipose Tissue and Cardiovascular Risk Reduction by Pomegranate Juice in Obesity Induced by a Hypercaloric Diet in Wistar Rats
title_full_unstemmed Inflammation Markers in Adipose Tissue and Cardiovascular Risk Reduction by Pomegranate Juice in Obesity Induced by a Hypercaloric Diet in Wistar Rats
title_short Inflammation Markers in Adipose Tissue and Cardiovascular Risk Reduction by Pomegranate Juice in Obesity Induced by a Hypercaloric Diet in Wistar Rats
title_sort inflammation markers in adipose tissue and cardiovascular risk reduction by pomegranate juice in obesity induced by a hypercaloric diet in wistar rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402035/
https://www.ncbi.nlm.nih.gov/pubmed/34444736
http://dx.doi.org/10.3390/nu13082577
work_keys_str_mv AT michicotlmenesesmariamonica inflammationmarkersinadiposetissueandcardiovascularriskreductionbypomegranatejuiceinobesityinducedbyahypercaloricdietinwistarrats
AT thompsonbonillamariadelrocio inflammationmarkersinadiposetissueandcardiovascularriskreductionbypomegranatejuiceinobesityinducedbyahypercaloricdietinwistarrats
AT reyeslopezcesara inflammationmarkersinadiposetissueandcardiovascularriskreductionbypomegranatejuiceinobesityinducedbyahypercaloricdietinwistarrats
AT garciaperezblancaestela inflammationmarkersinadiposetissueandcardiovascularriskreductionbypomegranatejuiceinobesityinducedbyahypercaloricdietinwistarrats
AT lopeztenorioitzeli inflammationmarkersinadiposetissueandcardiovascularriskreductionbypomegranatejuiceinobesityinducedbyahypercaloricdietinwistarrats
AT ordazpichardocynthia inflammationmarkersinadiposetissueandcardiovascularriskreductionbypomegranatejuiceinobesityinducedbyahypercaloricdietinwistarrats
AT jaramillofloresmariaeugenia inflammationmarkersinadiposetissueandcardiovascularriskreductionbypomegranatejuiceinobesityinducedbyahypercaloricdietinwistarrats