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Recycled Porcine Bone Powder as Filler in Thermoplastic Composite Materials Enriched with Chitosan for a Bone Scaffold Application

This work aims to synthesize biocompatible composite materials loaded with recycled porcine bone powder (BP) to fabricate scaffolds for in-situ reconstruction of bone structures. Polylactic acid (PLA) and poly(ε-caprolactone) (PCL) were tested as matrices in percentages from 40 wt% to 80 wt%. Chitos...

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Autores principales: Valente, Marco, Puiggalí, Jordi, del Valle, Luis J., Titolo, Gioconda, Sambucci, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402051/
https://www.ncbi.nlm.nih.gov/pubmed/34451290
http://dx.doi.org/10.3390/polym13162751
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author Valente, Marco
Puiggalí, Jordi
del Valle, Luis J.
Titolo, Gioconda
Sambucci, Matteo
author_facet Valente, Marco
Puiggalí, Jordi
del Valle, Luis J.
Titolo, Gioconda
Sambucci, Matteo
author_sort Valente, Marco
collection PubMed
description This work aims to synthesize biocompatible composite materials loaded with recycled porcine bone powder (BP) to fabricate scaffolds for in-situ reconstruction of bone structures. Polylactic acid (PLA) and poly(ε-caprolactone) (PCL) were tested as matrices in percentages from 40 wt% to 80 wt%. Chitosan (CS) was selected for its antibacterial properties, in the amount from 5 wt% to 15 wt%, and BP from 20 wt% to 50 wt% as active filler to promote osseointegration. In this preliminary investigation, samples have been produced by solvent casting to introduce the highest possible percentage of fillers. PCL has been chosen as a matrix due to its greater ability to incorporate fillers, ensuring their adequate dispersion and lower working temperatures compared to PLA. Tensile tests demonstrated strength properties (6–10 MPa) suitable for hard tissue engineering applications. Based on the different findings (integration of PLA in the composite system, improvements in CS adhesion and mechanical properties), the authors supposed an optimization of the synthesis process, focused on the possible implementation of the electrospinning technique to develop PCL-BP composites reinforced with PLA-CS microfibers. Finally, biological tests were conducted to evaluate the antibacterial activity of CS, demonstrating the applicability of the materials for the biomedical field.
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spelling pubmed-84020512021-08-29 Recycled Porcine Bone Powder as Filler in Thermoplastic Composite Materials Enriched with Chitosan for a Bone Scaffold Application Valente, Marco Puiggalí, Jordi del Valle, Luis J. Titolo, Gioconda Sambucci, Matteo Polymers (Basel) Article This work aims to synthesize biocompatible composite materials loaded with recycled porcine bone powder (BP) to fabricate scaffolds for in-situ reconstruction of bone structures. Polylactic acid (PLA) and poly(ε-caprolactone) (PCL) were tested as matrices in percentages from 40 wt% to 80 wt%. Chitosan (CS) was selected for its antibacterial properties, in the amount from 5 wt% to 15 wt%, and BP from 20 wt% to 50 wt% as active filler to promote osseointegration. In this preliminary investigation, samples have been produced by solvent casting to introduce the highest possible percentage of fillers. PCL has been chosen as a matrix due to its greater ability to incorporate fillers, ensuring their adequate dispersion and lower working temperatures compared to PLA. Tensile tests demonstrated strength properties (6–10 MPa) suitable for hard tissue engineering applications. Based on the different findings (integration of PLA in the composite system, improvements in CS adhesion and mechanical properties), the authors supposed an optimization of the synthesis process, focused on the possible implementation of the electrospinning technique to develop PCL-BP composites reinforced with PLA-CS microfibers. Finally, biological tests were conducted to evaluate the antibacterial activity of CS, demonstrating the applicability of the materials for the biomedical field. MDPI 2021-08-16 /pmc/articles/PMC8402051/ /pubmed/34451290 http://dx.doi.org/10.3390/polym13162751 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Valente, Marco
Puiggalí, Jordi
del Valle, Luis J.
Titolo, Gioconda
Sambucci, Matteo
Recycled Porcine Bone Powder as Filler in Thermoplastic Composite Materials Enriched with Chitosan for a Bone Scaffold Application
title Recycled Porcine Bone Powder as Filler in Thermoplastic Composite Materials Enriched with Chitosan for a Bone Scaffold Application
title_full Recycled Porcine Bone Powder as Filler in Thermoplastic Composite Materials Enriched with Chitosan for a Bone Scaffold Application
title_fullStr Recycled Porcine Bone Powder as Filler in Thermoplastic Composite Materials Enriched with Chitosan for a Bone Scaffold Application
title_full_unstemmed Recycled Porcine Bone Powder as Filler in Thermoplastic Composite Materials Enriched with Chitosan for a Bone Scaffold Application
title_short Recycled Porcine Bone Powder as Filler in Thermoplastic Composite Materials Enriched with Chitosan for a Bone Scaffold Application
title_sort recycled porcine bone powder as filler in thermoplastic composite materials enriched with chitosan for a bone scaffold application
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402051/
https://www.ncbi.nlm.nih.gov/pubmed/34451290
http://dx.doi.org/10.3390/polym13162751
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