Cargando…
Recycled Porcine Bone Powder as Filler in Thermoplastic Composite Materials Enriched with Chitosan for a Bone Scaffold Application
This work aims to synthesize biocompatible composite materials loaded with recycled porcine bone powder (BP) to fabricate scaffolds for in-situ reconstruction of bone structures. Polylactic acid (PLA) and poly(ε-caprolactone) (PCL) were tested as matrices in percentages from 40 wt% to 80 wt%. Chitos...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402051/ https://www.ncbi.nlm.nih.gov/pubmed/34451290 http://dx.doi.org/10.3390/polym13162751 |
_version_ | 1783745696001687552 |
---|---|
author | Valente, Marco Puiggalí, Jordi del Valle, Luis J. Titolo, Gioconda Sambucci, Matteo |
author_facet | Valente, Marco Puiggalí, Jordi del Valle, Luis J. Titolo, Gioconda Sambucci, Matteo |
author_sort | Valente, Marco |
collection | PubMed |
description | This work aims to synthesize biocompatible composite materials loaded with recycled porcine bone powder (BP) to fabricate scaffolds for in-situ reconstruction of bone structures. Polylactic acid (PLA) and poly(ε-caprolactone) (PCL) were tested as matrices in percentages from 40 wt% to 80 wt%. Chitosan (CS) was selected for its antibacterial properties, in the amount from 5 wt% to 15 wt%, and BP from 20 wt% to 50 wt% as active filler to promote osseointegration. In this preliminary investigation, samples have been produced by solvent casting to introduce the highest possible percentage of fillers. PCL has been chosen as a matrix due to its greater ability to incorporate fillers, ensuring their adequate dispersion and lower working temperatures compared to PLA. Tensile tests demonstrated strength properties (6–10 MPa) suitable for hard tissue engineering applications. Based on the different findings (integration of PLA in the composite system, improvements in CS adhesion and mechanical properties), the authors supposed an optimization of the synthesis process, focused on the possible implementation of the electrospinning technique to develop PCL-BP composites reinforced with PLA-CS microfibers. Finally, biological tests were conducted to evaluate the antibacterial activity of CS, demonstrating the applicability of the materials for the biomedical field. |
format | Online Article Text |
id | pubmed-8402051 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84020512021-08-29 Recycled Porcine Bone Powder as Filler in Thermoplastic Composite Materials Enriched with Chitosan for a Bone Scaffold Application Valente, Marco Puiggalí, Jordi del Valle, Luis J. Titolo, Gioconda Sambucci, Matteo Polymers (Basel) Article This work aims to synthesize biocompatible composite materials loaded with recycled porcine bone powder (BP) to fabricate scaffolds for in-situ reconstruction of bone structures. Polylactic acid (PLA) and poly(ε-caprolactone) (PCL) were tested as matrices in percentages from 40 wt% to 80 wt%. Chitosan (CS) was selected for its antibacterial properties, in the amount from 5 wt% to 15 wt%, and BP from 20 wt% to 50 wt% as active filler to promote osseointegration. In this preliminary investigation, samples have been produced by solvent casting to introduce the highest possible percentage of fillers. PCL has been chosen as a matrix due to its greater ability to incorporate fillers, ensuring their adequate dispersion and lower working temperatures compared to PLA. Tensile tests demonstrated strength properties (6–10 MPa) suitable for hard tissue engineering applications. Based on the different findings (integration of PLA in the composite system, improvements in CS adhesion and mechanical properties), the authors supposed an optimization of the synthesis process, focused on the possible implementation of the electrospinning technique to develop PCL-BP composites reinforced with PLA-CS microfibers. Finally, biological tests were conducted to evaluate the antibacterial activity of CS, demonstrating the applicability of the materials for the biomedical field. MDPI 2021-08-16 /pmc/articles/PMC8402051/ /pubmed/34451290 http://dx.doi.org/10.3390/polym13162751 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Valente, Marco Puiggalí, Jordi del Valle, Luis J. Titolo, Gioconda Sambucci, Matteo Recycled Porcine Bone Powder as Filler in Thermoplastic Composite Materials Enriched with Chitosan for a Bone Scaffold Application |
title | Recycled Porcine Bone Powder as Filler in Thermoplastic Composite Materials Enriched with Chitosan for a Bone Scaffold Application |
title_full | Recycled Porcine Bone Powder as Filler in Thermoplastic Composite Materials Enriched with Chitosan for a Bone Scaffold Application |
title_fullStr | Recycled Porcine Bone Powder as Filler in Thermoplastic Composite Materials Enriched with Chitosan for a Bone Scaffold Application |
title_full_unstemmed | Recycled Porcine Bone Powder as Filler in Thermoplastic Composite Materials Enriched with Chitosan for a Bone Scaffold Application |
title_short | Recycled Porcine Bone Powder as Filler in Thermoplastic Composite Materials Enriched with Chitosan for a Bone Scaffold Application |
title_sort | recycled porcine bone powder as filler in thermoplastic composite materials enriched with chitosan for a bone scaffold application |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402051/ https://www.ncbi.nlm.nih.gov/pubmed/34451290 http://dx.doi.org/10.3390/polym13162751 |
work_keys_str_mv | AT valentemarco recycledporcinebonepowderasfillerinthermoplasticcompositematerialsenrichedwithchitosanforabonescaffoldapplication AT puiggalijordi recycledporcinebonepowderasfillerinthermoplasticcompositematerialsenrichedwithchitosanforabonescaffoldapplication AT delvalleluisj recycledporcinebonepowderasfillerinthermoplasticcompositematerialsenrichedwithchitosanforabonescaffoldapplication AT titologioconda recycledporcinebonepowderasfillerinthermoplasticcompositematerialsenrichedwithchitosanforabonescaffoldapplication AT sambuccimatteo recycledporcinebonepowderasfillerinthermoplasticcompositematerialsenrichedwithchitosanforabonescaffoldapplication |