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Risk Factors for Hepatotoxicity Due to Paracetamol Overdose in Adults
Background and Objectives: Over-the-counter availability and a good safety profile make paracetamol one of the most common analgesics in developed countries but also the leading cause of liver failure due to overdose. The objectives of the study were to identify modifiable risk factors for severe he...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402128/ https://www.ncbi.nlm.nih.gov/pubmed/34440958 http://dx.doi.org/10.3390/medicina57080752 |
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author | Popiolek, Iwona Hydzik, Piotr Jagielski, Pawel Zrodlowska, Monika Mystek, Karol Porebski, Grzegorz |
author_facet | Popiolek, Iwona Hydzik, Piotr Jagielski, Pawel Zrodlowska, Monika Mystek, Karol Porebski, Grzegorz |
author_sort | Popiolek, Iwona |
collection | PubMed |
description | Background and Objectives: Over-the-counter availability and a good safety profile make paracetamol one of the most common analgesics in developed countries but also the leading cause of liver failure due to overdose. The objectives of the study were to identify modifiable risk factors for severe hepatotoxicity following paracetamol overdose in adults. Materials and Methods: A retrospective cohort study involved the consecutive adult patients hospitalized in a toxicological center over a period of seven years due to paracetamol overdose. Complete medical datasets of laboratory and anamnestic variables were analyzed and validated by means of logistic regression model. Results: A total of 185 patients entered the study, including 25 individuals who developed severe hepatotoxicity (plasma aminotransferases levels above 1000 UI/L) and 31 individuals with mild to moderate liver injury (plasma aminotransferases levels above upper normal range, but below 1000 UI/L). In the univariable analysis, significant hepatotoxicity risk factors were male gender, alcohol abuse, an ingested paracetamol dose, and a timespan from ingestion to hospital admission. The later one was the only significant risk factor in the multivariable model (adjusted odds ratio 1.08; 95% CI: 1.03–1.12). Conclusions: A delay in hospital admission, resulting in a delayed administration of disease-specific treatment outweighs any other known risk factors of paracetamol-induced hepatotoxicity. |
format | Online Article Text |
id | pubmed-8402128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84021282021-08-29 Risk Factors for Hepatotoxicity Due to Paracetamol Overdose in Adults Popiolek, Iwona Hydzik, Piotr Jagielski, Pawel Zrodlowska, Monika Mystek, Karol Porebski, Grzegorz Medicina (Kaunas) Article Background and Objectives: Over-the-counter availability and a good safety profile make paracetamol one of the most common analgesics in developed countries but also the leading cause of liver failure due to overdose. The objectives of the study were to identify modifiable risk factors for severe hepatotoxicity following paracetamol overdose in adults. Materials and Methods: A retrospective cohort study involved the consecutive adult patients hospitalized in a toxicological center over a period of seven years due to paracetamol overdose. Complete medical datasets of laboratory and anamnestic variables were analyzed and validated by means of logistic regression model. Results: A total of 185 patients entered the study, including 25 individuals who developed severe hepatotoxicity (plasma aminotransferases levels above 1000 UI/L) and 31 individuals with mild to moderate liver injury (plasma aminotransferases levels above upper normal range, but below 1000 UI/L). In the univariable analysis, significant hepatotoxicity risk factors were male gender, alcohol abuse, an ingested paracetamol dose, and a timespan from ingestion to hospital admission. The later one was the only significant risk factor in the multivariable model (adjusted odds ratio 1.08; 95% CI: 1.03–1.12). Conclusions: A delay in hospital admission, resulting in a delayed administration of disease-specific treatment outweighs any other known risk factors of paracetamol-induced hepatotoxicity. MDPI 2021-07-25 /pmc/articles/PMC8402128/ /pubmed/34440958 http://dx.doi.org/10.3390/medicina57080752 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Popiolek, Iwona Hydzik, Piotr Jagielski, Pawel Zrodlowska, Monika Mystek, Karol Porebski, Grzegorz Risk Factors for Hepatotoxicity Due to Paracetamol Overdose in Adults |
title | Risk Factors for Hepatotoxicity Due to Paracetamol Overdose in Adults |
title_full | Risk Factors for Hepatotoxicity Due to Paracetamol Overdose in Adults |
title_fullStr | Risk Factors for Hepatotoxicity Due to Paracetamol Overdose in Adults |
title_full_unstemmed | Risk Factors for Hepatotoxicity Due to Paracetamol Overdose in Adults |
title_short | Risk Factors for Hepatotoxicity Due to Paracetamol Overdose in Adults |
title_sort | risk factors for hepatotoxicity due to paracetamol overdose in adults |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402128/ https://www.ncbi.nlm.nih.gov/pubmed/34440958 http://dx.doi.org/10.3390/medicina57080752 |
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