An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era

The emergence of SARS-CoV-2 in late 2019 led to the COVID-19 pandemic all over the world. When the virus was first isolated and its genome was sequenced in the early months of 2020, the efforts to develop a vaccine began. Based on prior well-known knowledge about coronavirus, the SARS-CoV-2 spike (S...

Descripción completa

Detalles Bibliográficos
Autores principales: Pascual-Iglesias, Alejandro, Canton, Javier, Ortega-Prieto, Ana Maria, Jimenez-Guardeño, Jose M., Regla-Nava, Jose Angel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402174/
https://www.ncbi.nlm.nih.gov/pubmed/34451494
http://dx.doi.org/10.3390/pathogens10081030
Descripción
Sumario:The emergence of SARS-CoV-2 in late 2019 led to the COVID-19 pandemic all over the world. When the virus was first isolated and its genome was sequenced in the early months of 2020, the efforts to develop a vaccine began. Based on prior well-known knowledge about coronavirus, the SARS-CoV-2 spike (S) protein was selected as the main target. Currently, more than one hundred vaccines are being investigated and several of them are already authorized by medical agencies. This review summarizes and compares the current knowledge about main approaches for vaccine development, focusing on those authorized and specifically their immunogenicity, efficacy preventing severe disease, adverse side effects, protection, and ability to cope with emergent SARS-CoV-2 variants.

Ejemplares similares