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An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era
The emergence of SARS-CoV-2 in late 2019 led to the COVID-19 pandemic all over the world. When the virus was first isolated and its genome was sequenced in the early months of 2020, the efforts to develop a vaccine began. Based on prior well-known knowledge about coronavirus, the SARS-CoV-2 spike (S...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402174/ https://www.ncbi.nlm.nih.gov/pubmed/34451494 http://dx.doi.org/10.3390/pathogens10081030 |
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author | Pascual-Iglesias, Alejandro Canton, Javier Ortega-Prieto, Ana Maria Jimenez-Guardeño, Jose M. Regla-Nava, Jose Angel |
author_facet | Pascual-Iglesias, Alejandro Canton, Javier Ortega-Prieto, Ana Maria Jimenez-Guardeño, Jose M. Regla-Nava, Jose Angel |
author_sort | Pascual-Iglesias, Alejandro |
collection | PubMed |
description | The emergence of SARS-CoV-2 in late 2019 led to the COVID-19 pandemic all over the world. When the virus was first isolated and its genome was sequenced in the early months of 2020, the efforts to develop a vaccine began. Based on prior well-known knowledge about coronavirus, the SARS-CoV-2 spike (S) protein was selected as the main target. Currently, more than one hundred vaccines are being investigated and several of them are already authorized by medical agencies. This review summarizes and compares the current knowledge about main approaches for vaccine development, focusing on those authorized and specifically their immunogenicity, efficacy preventing severe disease, adverse side effects, protection, and ability to cope with emergent SARS-CoV-2 variants. |
format | Online Article Text |
id | pubmed-8402174 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84021742021-08-29 An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era Pascual-Iglesias, Alejandro Canton, Javier Ortega-Prieto, Ana Maria Jimenez-Guardeño, Jose M. Regla-Nava, Jose Angel Pathogens Review The emergence of SARS-CoV-2 in late 2019 led to the COVID-19 pandemic all over the world. When the virus was first isolated and its genome was sequenced in the early months of 2020, the efforts to develop a vaccine began. Based on prior well-known knowledge about coronavirus, the SARS-CoV-2 spike (S) protein was selected as the main target. Currently, more than one hundred vaccines are being investigated and several of them are already authorized by medical agencies. This review summarizes and compares the current knowledge about main approaches for vaccine development, focusing on those authorized and specifically their immunogenicity, efficacy preventing severe disease, adverse side effects, protection, and ability to cope with emergent SARS-CoV-2 variants. MDPI 2021-08-14 /pmc/articles/PMC8402174/ /pubmed/34451494 http://dx.doi.org/10.3390/pathogens10081030 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pascual-Iglesias, Alejandro Canton, Javier Ortega-Prieto, Ana Maria Jimenez-Guardeño, Jose M. Regla-Nava, Jose Angel An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era |
title | An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era |
title_full | An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era |
title_fullStr | An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era |
title_full_unstemmed | An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era |
title_short | An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era |
title_sort | overview of vaccines against sars-cov-2 in the covid-19 pandemic era |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402174/ https://www.ncbi.nlm.nih.gov/pubmed/34451494 http://dx.doi.org/10.3390/pathogens10081030 |
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