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An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era

The emergence of SARS-CoV-2 in late 2019 led to the COVID-19 pandemic all over the world. When the virus was first isolated and its genome was sequenced in the early months of 2020, the efforts to develop a vaccine began. Based on prior well-known knowledge about coronavirus, the SARS-CoV-2 spike (S...

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Autores principales: Pascual-Iglesias, Alejandro, Canton, Javier, Ortega-Prieto, Ana Maria, Jimenez-Guardeño, Jose M., Regla-Nava, Jose Angel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402174/
https://www.ncbi.nlm.nih.gov/pubmed/34451494
http://dx.doi.org/10.3390/pathogens10081030
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author Pascual-Iglesias, Alejandro
Canton, Javier
Ortega-Prieto, Ana Maria
Jimenez-Guardeño, Jose M.
Regla-Nava, Jose Angel
author_facet Pascual-Iglesias, Alejandro
Canton, Javier
Ortega-Prieto, Ana Maria
Jimenez-Guardeño, Jose M.
Regla-Nava, Jose Angel
author_sort Pascual-Iglesias, Alejandro
collection PubMed
description The emergence of SARS-CoV-2 in late 2019 led to the COVID-19 pandemic all over the world. When the virus was first isolated and its genome was sequenced in the early months of 2020, the efforts to develop a vaccine began. Based on prior well-known knowledge about coronavirus, the SARS-CoV-2 spike (S) protein was selected as the main target. Currently, more than one hundred vaccines are being investigated and several of them are already authorized by medical agencies. This review summarizes and compares the current knowledge about main approaches for vaccine development, focusing on those authorized and specifically their immunogenicity, efficacy preventing severe disease, adverse side effects, protection, and ability to cope with emergent SARS-CoV-2 variants.
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spelling pubmed-84021742021-08-29 An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era Pascual-Iglesias, Alejandro Canton, Javier Ortega-Prieto, Ana Maria Jimenez-Guardeño, Jose M. Regla-Nava, Jose Angel Pathogens Review The emergence of SARS-CoV-2 in late 2019 led to the COVID-19 pandemic all over the world. When the virus was first isolated and its genome was sequenced in the early months of 2020, the efforts to develop a vaccine began. Based on prior well-known knowledge about coronavirus, the SARS-CoV-2 spike (S) protein was selected as the main target. Currently, more than one hundred vaccines are being investigated and several of them are already authorized by medical agencies. This review summarizes and compares the current knowledge about main approaches for vaccine development, focusing on those authorized and specifically their immunogenicity, efficacy preventing severe disease, adverse side effects, protection, and ability to cope with emergent SARS-CoV-2 variants. MDPI 2021-08-14 /pmc/articles/PMC8402174/ /pubmed/34451494 http://dx.doi.org/10.3390/pathogens10081030 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pascual-Iglesias, Alejandro
Canton, Javier
Ortega-Prieto, Ana Maria
Jimenez-Guardeño, Jose M.
Regla-Nava, Jose Angel
An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era
title An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era
title_full An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era
title_fullStr An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era
title_full_unstemmed An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era
title_short An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era
title_sort overview of vaccines against sars-cov-2 in the covid-19 pandemic era
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402174/
https://www.ncbi.nlm.nih.gov/pubmed/34451494
http://dx.doi.org/10.3390/pathogens10081030
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