Cargando…

The Role of Autophagy Modulated by Exercise in Cancer Cachexia

Cancer cachexia is a syndrome experienced by many patients with cancer. Exercise can act as an autophagy modulator, and thus holds the potential to be used to treat cancer cachexia. Autophagy imbalance plays an important role in cancer cachexia, and is correlated to skeletal and cardiac muscle atrop...

Descripción completa

Detalles Bibliográficos
Autores principales: Gunadi, Julia Windi, Welliangan, Ariyani Sudhamma, Soetadji, Ray Sebastian, Jasaputra, Diana Krisanti, Lesmana, Ronny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402221/
https://www.ncbi.nlm.nih.gov/pubmed/34440525
http://dx.doi.org/10.3390/life11080781
_version_ 1783745736251277312
author Gunadi, Julia Windi
Welliangan, Ariyani Sudhamma
Soetadji, Ray Sebastian
Jasaputra, Diana Krisanti
Lesmana, Ronny
author_facet Gunadi, Julia Windi
Welliangan, Ariyani Sudhamma
Soetadji, Ray Sebastian
Jasaputra, Diana Krisanti
Lesmana, Ronny
author_sort Gunadi, Julia Windi
collection PubMed
description Cancer cachexia is a syndrome experienced by many patients with cancer. Exercise can act as an autophagy modulator, and thus holds the potential to be used to treat cancer cachexia. Autophagy imbalance plays an important role in cancer cachexia, and is correlated to skeletal and cardiac muscle atrophy and energy-wasting in the liver. The molecular mechanism of autophagy modulation in different types of exercise has not yet been clearly defined. This review aims to elaborate on the role of exercise in modulating autophagy in cancer cachexia. We evaluated nine studies in the literature and found a potential correlation between the type of exercise and autophagy modulation. Combined exercise or aerobic exercise alone seems more beneficial than resistance exercise alone in cancer cachexia. Looking ahead, determining the physiological role of autophagy modulated by exercise will support the development of a new medical approach for treating cancer cachexia. In addition, the harmonization of the exercise type, intensity, and duration might play a key role in optimizing the autophagy levels to preserve muscle function and regulate energy utilization in the liver.
format Online
Article
Text
id pubmed-8402221
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84022212021-08-29 The Role of Autophagy Modulated by Exercise in Cancer Cachexia Gunadi, Julia Windi Welliangan, Ariyani Sudhamma Soetadji, Ray Sebastian Jasaputra, Diana Krisanti Lesmana, Ronny Life (Basel) Review Cancer cachexia is a syndrome experienced by many patients with cancer. Exercise can act as an autophagy modulator, and thus holds the potential to be used to treat cancer cachexia. Autophagy imbalance plays an important role in cancer cachexia, and is correlated to skeletal and cardiac muscle atrophy and energy-wasting in the liver. The molecular mechanism of autophagy modulation in different types of exercise has not yet been clearly defined. This review aims to elaborate on the role of exercise in modulating autophagy in cancer cachexia. We evaluated nine studies in the literature and found a potential correlation between the type of exercise and autophagy modulation. Combined exercise or aerobic exercise alone seems more beneficial than resistance exercise alone in cancer cachexia. Looking ahead, determining the physiological role of autophagy modulated by exercise will support the development of a new medical approach for treating cancer cachexia. In addition, the harmonization of the exercise type, intensity, and duration might play a key role in optimizing the autophagy levels to preserve muscle function and regulate energy utilization in the liver. MDPI 2021-08-02 /pmc/articles/PMC8402221/ /pubmed/34440525 http://dx.doi.org/10.3390/life11080781 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gunadi, Julia Windi
Welliangan, Ariyani Sudhamma
Soetadji, Ray Sebastian
Jasaputra, Diana Krisanti
Lesmana, Ronny
The Role of Autophagy Modulated by Exercise in Cancer Cachexia
title The Role of Autophagy Modulated by Exercise in Cancer Cachexia
title_full The Role of Autophagy Modulated by Exercise in Cancer Cachexia
title_fullStr The Role of Autophagy Modulated by Exercise in Cancer Cachexia
title_full_unstemmed The Role of Autophagy Modulated by Exercise in Cancer Cachexia
title_short The Role of Autophagy Modulated by Exercise in Cancer Cachexia
title_sort role of autophagy modulated by exercise in cancer cachexia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402221/
https://www.ncbi.nlm.nih.gov/pubmed/34440525
http://dx.doi.org/10.3390/life11080781
work_keys_str_mv AT gunadijuliawindi theroleofautophagymodulatedbyexerciseincancercachexia
AT wellianganariyanisudhamma theroleofautophagymodulatedbyexerciseincancercachexia
AT soetadjiraysebastian theroleofautophagymodulatedbyexerciseincancercachexia
AT jasaputradianakrisanti theroleofautophagymodulatedbyexerciseincancercachexia
AT lesmanaronny theroleofautophagymodulatedbyexerciseincancercachexia
AT gunadijuliawindi roleofautophagymodulatedbyexerciseincancercachexia
AT wellianganariyanisudhamma roleofautophagymodulatedbyexerciseincancercachexia
AT soetadjiraysebastian roleofautophagymodulatedbyexerciseincancercachexia
AT jasaputradianakrisanti roleofautophagymodulatedbyexerciseincancercachexia
AT lesmanaronny roleofautophagymodulatedbyexerciseincancercachexia