Cargando…

The Pharmaceutical Technology Approach on Imaging Innovations from Italian Research

Many modern therapeutic approaches are based on precise diagnostic evidence, where imaging procedures play an essential role. To date, in the diagnostic field, a plethora of agents have been investigated to increase the selectivity and sensitivity of diagnosis. However, the most common drawbacks of...

Descripción completa

Detalles Bibliográficos
Autores principales: Ailuno, Giorgia, Iacobazzi, Rosa Maria, Lopalco, Antonio, Baldassari, Sara, Arduino, Ilaria, Azzariti, Amalia, Pastorino, Sara, Caviglioli, Gabriele, Denora, Nunzio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402236/
https://www.ncbi.nlm.nih.gov/pubmed/34452175
http://dx.doi.org/10.3390/pharmaceutics13081214
_version_ 1783745739959042048
author Ailuno, Giorgia
Iacobazzi, Rosa Maria
Lopalco, Antonio
Baldassari, Sara
Arduino, Ilaria
Azzariti, Amalia
Pastorino, Sara
Caviglioli, Gabriele
Denora, Nunzio
author_facet Ailuno, Giorgia
Iacobazzi, Rosa Maria
Lopalco, Antonio
Baldassari, Sara
Arduino, Ilaria
Azzariti, Amalia
Pastorino, Sara
Caviglioli, Gabriele
Denora, Nunzio
author_sort Ailuno, Giorgia
collection PubMed
description Many modern therapeutic approaches are based on precise diagnostic evidence, where imaging procedures play an essential role. To date, in the diagnostic field, a plethora of agents have been investigated to increase the selectivity and sensitivity of diagnosis. However, the most common drawbacks of conventional imaging agents reside in their non-specificity, short imaging time, instability, and toxicity. Moreover, routinely used diagnostic agents have low molecular weights and consequently a rapid clearance and renal excretion, and this represents a limitation if long-lasting imaging analyses are to be conducted. Thus, the development of new agents for in vivo diagnostics requires not only a deep knowledge of the physical principles of the imaging techniques and of the physiopathological aspects of the disease but also of the relative pharmaceutical and biopharmaceutical requirements. In this scenario, skills in pharmaceutical technology have become highly indispensable in order to respond to these needs. This review specifically aims to collect examples of newly developed diagnostic agents connoting the importance of an appropriate formulation study for the realization of effective products. Within the context of pharmaceutical technology research in Italy, several groups have developed and patented promising agents for fluorescence and radioactive imaging, the most relevant of which are described hereafter.
format Online
Article
Text
id pubmed-8402236
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84022362021-08-29 The Pharmaceutical Technology Approach on Imaging Innovations from Italian Research Ailuno, Giorgia Iacobazzi, Rosa Maria Lopalco, Antonio Baldassari, Sara Arduino, Ilaria Azzariti, Amalia Pastorino, Sara Caviglioli, Gabriele Denora, Nunzio Pharmaceutics Review Many modern therapeutic approaches are based on precise diagnostic evidence, where imaging procedures play an essential role. To date, in the diagnostic field, a plethora of agents have been investigated to increase the selectivity and sensitivity of diagnosis. However, the most common drawbacks of conventional imaging agents reside in their non-specificity, short imaging time, instability, and toxicity. Moreover, routinely used diagnostic agents have low molecular weights and consequently a rapid clearance and renal excretion, and this represents a limitation if long-lasting imaging analyses are to be conducted. Thus, the development of new agents for in vivo diagnostics requires not only a deep knowledge of the physical principles of the imaging techniques and of the physiopathological aspects of the disease but also of the relative pharmaceutical and biopharmaceutical requirements. In this scenario, skills in pharmaceutical technology have become highly indispensable in order to respond to these needs. This review specifically aims to collect examples of newly developed diagnostic agents connoting the importance of an appropriate formulation study for the realization of effective products. Within the context of pharmaceutical technology research in Italy, several groups have developed and patented promising agents for fluorescence and radioactive imaging, the most relevant of which are described hereafter. MDPI 2021-08-06 /pmc/articles/PMC8402236/ /pubmed/34452175 http://dx.doi.org/10.3390/pharmaceutics13081214 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ailuno, Giorgia
Iacobazzi, Rosa Maria
Lopalco, Antonio
Baldassari, Sara
Arduino, Ilaria
Azzariti, Amalia
Pastorino, Sara
Caviglioli, Gabriele
Denora, Nunzio
The Pharmaceutical Technology Approach on Imaging Innovations from Italian Research
title The Pharmaceutical Technology Approach on Imaging Innovations from Italian Research
title_full The Pharmaceutical Technology Approach on Imaging Innovations from Italian Research
title_fullStr The Pharmaceutical Technology Approach on Imaging Innovations from Italian Research
title_full_unstemmed The Pharmaceutical Technology Approach on Imaging Innovations from Italian Research
title_short The Pharmaceutical Technology Approach on Imaging Innovations from Italian Research
title_sort pharmaceutical technology approach on imaging innovations from italian research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402236/
https://www.ncbi.nlm.nih.gov/pubmed/34452175
http://dx.doi.org/10.3390/pharmaceutics13081214
work_keys_str_mv AT ailunogiorgia thepharmaceuticaltechnologyapproachonimaginginnovationsfromitalianresearch
AT iacobazzirosamaria thepharmaceuticaltechnologyapproachonimaginginnovationsfromitalianresearch
AT lopalcoantonio thepharmaceuticaltechnologyapproachonimaginginnovationsfromitalianresearch
AT baldassarisara thepharmaceuticaltechnologyapproachonimaginginnovationsfromitalianresearch
AT arduinoilaria thepharmaceuticaltechnologyapproachonimaginginnovationsfromitalianresearch
AT azzaritiamalia thepharmaceuticaltechnologyapproachonimaginginnovationsfromitalianresearch
AT pastorinosara thepharmaceuticaltechnologyapproachonimaginginnovationsfromitalianresearch
AT caviglioligabriele thepharmaceuticaltechnologyapproachonimaginginnovationsfromitalianresearch
AT denoranunzio thepharmaceuticaltechnologyapproachonimaginginnovationsfromitalianresearch
AT ailunogiorgia pharmaceuticaltechnologyapproachonimaginginnovationsfromitalianresearch
AT iacobazzirosamaria pharmaceuticaltechnologyapproachonimaginginnovationsfromitalianresearch
AT lopalcoantonio pharmaceuticaltechnologyapproachonimaginginnovationsfromitalianresearch
AT baldassarisara pharmaceuticaltechnologyapproachonimaginginnovationsfromitalianresearch
AT arduinoilaria pharmaceuticaltechnologyapproachonimaginginnovationsfromitalianresearch
AT azzaritiamalia pharmaceuticaltechnologyapproachonimaginginnovationsfromitalianresearch
AT pastorinosara pharmaceuticaltechnologyapproachonimaginginnovationsfromitalianresearch
AT caviglioligabriele pharmaceuticaltechnologyapproachonimaginginnovationsfromitalianresearch
AT denoranunzio pharmaceuticaltechnologyapproachonimaginginnovationsfromitalianresearch