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Assessment of the Use of Multi-Channel Organic Electrodes to Record ENG on Small Nerves: Application to Phrenic Nerve Burst Detection

Effective closed-loop neuromodulation relies on the acquisition of appropriate physiological control variables and the delivery of an appropriate stimulation signal. In particular, electroneurogram (ENG) data acquired from a set of electrodes applied at the surface of the nerve may be used as a pote...

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Autores principales: Avdeew, Yvan, Bergé-Laval, Victor, Le Rolle, Virginie, Dieuset, Gabriel, Moreau, David, Kergoat, Loïg, Martin, Benoît, Bernard, Christophe, Gestreau, Christian, Hernández, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402313/
https://www.ncbi.nlm.nih.gov/pubmed/34451031
http://dx.doi.org/10.3390/s21165594
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author Avdeew, Yvan
Bergé-Laval, Victor
Le Rolle, Virginie
Dieuset, Gabriel
Moreau, David
Kergoat, Loïg
Martin, Benoît
Bernard, Christophe
Gestreau, Christian
Hernández, Alfredo
author_facet Avdeew, Yvan
Bergé-Laval, Victor
Le Rolle, Virginie
Dieuset, Gabriel
Moreau, David
Kergoat, Loïg
Martin, Benoît
Bernard, Christophe
Gestreau, Christian
Hernández, Alfredo
author_sort Avdeew, Yvan
collection PubMed
description Effective closed-loop neuromodulation relies on the acquisition of appropriate physiological control variables and the delivery of an appropriate stimulation signal. In particular, electroneurogram (ENG) data acquired from a set of electrodes applied at the surface of the nerve may be used as a potential control variable in this field. Improved electrode technologies and data processing methods are clearly needed in this context. In this work, we evaluated a new electrode technology based on multichannel organic electrodes (OE) and applied a signal processing chain in order to detect respiratory-related bursts from the phrenic nerve. Phrenic ENG (pENG) were acquired from nine Long Evans rats in situ preparations. For each preparation, a 16-channel OE was applied around the phrenic nerve’s surface and a suction electrode was applied to the cut end of the same nerve. The former electrode provided input multivariate pENG signals while the latter electrode provided the gold standard for data analysis. Correlations between OE signals and that from the gold standard were estimated. Signal to noise ratio (SNR) and ROC curves were built to quantify phrenic bursts detection performance. Correlation score showed the ability of the OE to record high-quality pENG. Our methods allowed good phrenic bursts detection. However, we failed to demonstrate a spatial selectivity from the multiple pENG recorded with our OE matrix. Altogether, our results suggest that highly flexible and biocompatible multi-channel electrode may represent an interesting alternative to metallic cuff electrodes to perform nerve bursts detection and/or closed-loop neuromodulation.
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spelling pubmed-84023132021-08-29 Assessment of the Use of Multi-Channel Organic Electrodes to Record ENG on Small Nerves: Application to Phrenic Nerve Burst Detection Avdeew, Yvan Bergé-Laval, Victor Le Rolle, Virginie Dieuset, Gabriel Moreau, David Kergoat, Loïg Martin, Benoît Bernard, Christophe Gestreau, Christian Hernández, Alfredo Sensors (Basel) Article Effective closed-loop neuromodulation relies on the acquisition of appropriate physiological control variables and the delivery of an appropriate stimulation signal. In particular, electroneurogram (ENG) data acquired from a set of electrodes applied at the surface of the nerve may be used as a potential control variable in this field. Improved electrode technologies and data processing methods are clearly needed in this context. In this work, we evaluated a new electrode technology based on multichannel organic electrodes (OE) and applied a signal processing chain in order to detect respiratory-related bursts from the phrenic nerve. Phrenic ENG (pENG) were acquired from nine Long Evans rats in situ preparations. For each preparation, a 16-channel OE was applied around the phrenic nerve’s surface and a suction electrode was applied to the cut end of the same nerve. The former electrode provided input multivariate pENG signals while the latter electrode provided the gold standard for data analysis. Correlations between OE signals and that from the gold standard were estimated. Signal to noise ratio (SNR) and ROC curves were built to quantify phrenic bursts detection performance. Correlation score showed the ability of the OE to record high-quality pENG. Our methods allowed good phrenic bursts detection. However, we failed to demonstrate a spatial selectivity from the multiple pENG recorded with our OE matrix. Altogether, our results suggest that highly flexible and biocompatible multi-channel electrode may represent an interesting alternative to metallic cuff electrodes to perform nerve bursts detection and/or closed-loop neuromodulation. MDPI 2021-08-19 /pmc/articles/PMC8402313/ /pubmed/34451031 http://dx.doi.org/10.3390/s21165594 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Avdeew, Yvan
Bergé-Laval, Victor
Le Rolle, Virginie
Dieuset, Gabriel
Moreau, David
Kergoat, Loïg
Martin, Benoît
Bernard, Christophe
Gestreau, Christian
Hernández, Alfredo
Assessment of the Use of Multi-Channel Organic Electrodes to Record ENG on Small Nerves: Application to Phrenic Nerve Burst Detection
title Assessment of the Use of Multi-Channel Organic Electrodes to Record ENG on Small Nerves: Application to Phrenic Nerve Burst Detection
title_full Assessment of the Use of Multi-Channel Organic Electrodes to Record ENG on Small Nerves: Application to Phrenic Nerve Burst Detection
title_fullStr Assessment of the Use of Multi-Channel Organic Electrodes to Record ENG on Small Nerves: Application to Phrenic Nerve Burst Detection
title_full_unstemmed Assessment of the Use of Multi-Channel Organic Electrodes to Record ENG on Small Nerves: Application to Phrenic Nerve Burst Detection
title_short Assessment of the Use of Multi-Channel Organic Electrodes to Record ENG on Small Nerves: Application to Phrenic Nerve Burst Detection
title_sort assessment of the use of multi-channel organic electrodes to record eng on small nerves: application to phrenic nerve burst detection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402313/
https://www.ncbi.nlm.nih.gov/pubmed/34451031
http://dx.doi.org/10.3390/s21165594
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