Regional Delivery of Anti-PD-1 Agent for Colorectal Liver Metastases Improves Therapeutic Index and Anti-Tumor Activity

Metastatic liver tumors have presented challenges with the use of checkpoint inhibitors (CPIs), with only limited success. We hypothesize that regional delivery (RD) of CPIs can improve activity in the liver and minimize systemic exposure, thereby reducing immune-related adverse events (irAE). Using...

Descripción completa

Detalles Bibliográficos
Autores principales: Chai, Louis F., Hardaway, John C., Heatherton, Kara R., O’Connell, Kyle P., Lopes, Mikayla C., Rabinowitz, Benjamin A., Ghosh, Chandra C., Guha, Prajna, Jaroch, David, Cox, Bryan F., Katz, Steven C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402391/
https://www.ncbi.nlm.nih.gov/pubmed/34451932
http://dx.doi.org/10.3390/vaccines9080807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402391/
https://www.ncbi.nlm.nih.gov/pubmed/34451932
http://dx.doi.org/10.3390/vaccines9080807

Ejemplares similares