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Next-Generation Bioinformatics Approaches and Resources for Coronavirus Vaccine Discovery and Development—A Perspective Review

COVID-19 is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To fight this pandemic, which has caused a massive death toll around the globe, researchers are putting efforts into developing an effective vaccine against the pathogen. As genome sequencing pro...

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Autores principales: Chatterjee, Rahul, Ghosh, Mrinmoy, Sahoo, Susrita, Padhi, Santwana, Misra, Namrata, Raina, Visakha, Suar, Mrutyunjay, Son, Young-Ok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402397/
https://www.ncbi.nlm.nih.gov/pubmed/34451937
http://dx.doi.org/10.3390/vaccines9080812
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author Chatterjee, Rahul
Ghosh, Mrinmoy
Sahoo, Susrita
Padhi, Santwana
Misra, Namrata
Raina, Visakha
Suar, Mrutyunjay
Son, Young-Ok
author_facet Chatterjee, Rahul
Ghosh, Mrinmoy
Sahoo, Susrita
Padhi, Santwana
Misra, Namrata
Raina, Visakha
Suar, Mrutyunjay
Son, Young-Ok
author_sort Chatterjee, Rahul
collection PubMed
description COVID-19 is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To fight this pandemic, which has caused a massive death toll around the globe, researchers are putting efforts into developing an effective vaccine against the pathogen. As genome sequencing projects for several coronavirus strains have been completed, a detailed investigation of the functions of the proteins and their 3D structures has gained increasing attention. These high throughput data are a valuable resource for accelerating the emerging field of immuno-informatics, which is primarily aimed toward the identification of potential antigenic epitopes in viral proteins that can be targeted for the development of a vaccine construct eliciting a high immune response. Bioinformatics platforms and various computational tools and databases are also essential for the identification of promising vaccine targets making the best use of genomic resources, for further experimental validation. The present review focuses on the various stages of the vaccine development process and the vaccines available for COVID-19. Additionally, recent advances in genomic platforms and publicly available bioinformatics resources in coronavirus vaccine discovery together with related immunoinformatics databases and advances in technology are discussed.
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spelling pubmed-84023972021-08-29 Next-Generation Bioinformatics Approaches and Resources for Coronavirus Vaccine Discovery and Development—A Perspective Review Chatterjee, Rahul Ghosh, Mrinmoy Sahoo, Susrita Padhi, Santwana Misra, Namrata Raina, Visakha Suar, Mrutyunjay Son, Young-Ok Vaccines (Basel) Review COVID-19 is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To fight this pandemic, which has caused a massive death toll around the globe, researchers are putting efforts into developing an effective vaccine against the pathogen. As genome sequencing projects for several coronavirus strains have been completed, a detailed investigation of the functions of the proteins and their 3D structures has gained increasing attention. These high throughput data are a valuable resource for accelerating the emerging field of immuno-informatics, which is primarily aimed toward the identification of potential antigenic epitopes in viral proteins that can be targeted for the development of a vaccine construct eliciting a high immune response. Bioinformatics platforms and various computational tools and databases are also essential for the identification of promising vaccine targets making the best use of genomic resources, for further experimental validation. The present review focuses on the various stages of the vaccine development process and the vaccines available for COVID-19. Additionally, recent advances in genomic platforms and publicly available bioinformatics resources in coronavirus vaccine discovery together with related immunoinformatics databases and advances in technology are discussed. MDPI 2021-07-22 /pmc/articles/PMC8402397/ /pubmed/34451937 http://dx.doi.org/10.3390/vaccines9080812 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chatterjee, Rahul
Ghosh, Mrinmoy
Sahoo, Susrita
Padhi, Santwana
Misra, Namrata
Raina, Visakha
Suar, Mrutyunjay
Son, Young-Ok
Next-Generation Bioinformatics Approaches and Resources for Coronavirus Vaccine Discovery and Development—A Perspective Review
title Next-Generation Bioinformatics Approaches and Resources for Coronavirus Vaccine Discovery and Development—A Perspective Review
title_full Next-Generation Bioinformatics Approaches and Resources for Coronavirus Vaccine Discovery and Development—A Perspective Review
title_fullStr Next-Generation Bioinformatics Approaches and Resources for Coronavirus Vaccine Discovery and Development—A Perspective Review
title_full_unstemmed Next-Generation Bioinformatics Approaches and Resources for Coronavirus Vaccine Discovery and Development—A Perspective Review
title_short Next-Generation Bioinformatics Approaches and Resources for Coronavirus Vaccine Discovery and Development—A Perspective Review
title_sort next-generation bioinformatics approaches and resources for coronavirus vaccine discovery and development—a perspective review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402397/
https://www.ncbi.nlm.nih.gov/pubmed/34451937
http://dx.doi.org/10.3390/vaccines9080812
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