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The Search for a Schistosomiasis Vaccine: Australia’s Contribution
Schistosomiasis, a neglected tropical disease caused by parasitic flatworms of the genus Schistosoma, results in considerable human morbidity in sub-Saharan Africa, in particular, but also parts of the Middle East, South America, and Southeast Asia. The anti-schistosome drug praziquantel is efficaci...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402410/ https://www.ncbi.nlm.nih.gov/pubmed/34451997 http://dx.doi.org/10.3390/vaccines9080872 |
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author | McManus, Donald P. |
author_facet | McManus, Donald P. |
author_sort | McManus, Donald P. |
collection | PubMed |
description | Schistosomiasis, a neglected tropical disease caused by parasitic flatworms of the genus Schistosoma, results in considerable human morbidity in sub-Saharan Africa, in particular, but also parts of the Middle East, South America, and Southeast Asia. The anti-schistosome drug praziquantel is efficacious and safe against the adult parasites of all Schistosoma species infecting humans; however, it does not prevent reinfection and the development of drug resistance is a constant concern. The need to develop an effective vaccine is of great importance if the health of many in the developing world is to be improved. Indeed, vaccination, in combination with other public health measures, can provide an invaluable tool to achieve lasting control, leading to schistosomiasis elimination. Australia has played a leading role in schistosomiasis vaccine research over many years and this review presents an overview of some of the significant contributions made by Australian scientists in this important area. |
format | Online Article Text |
id | pubmed-8402410 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84024102021-08-29 The Search for a Schistosomiasis Vaccine: Australia’s Contribution McManus, Donald P. Vaccines (Basel) Review Schistosomiasis, a neglected tropical disease caused by parasitic flatworms of the genus Schistosoma, results in considerable human morbidity in sub-Saharan Africa, in particular, but also parts of the Middle East, South America, and Southeast Asia. The anti-schistosome drug praziquantel is efficacious and safe against the adult parasites of all Schistosoma species infecting humans; however, it does not prevent reinfection and the development of drug resistance is a constant concern. The need to develop an effective vaccine is of great importance if the health of many in the developing world is to be improved. Indeed, vaccination, in combination with other public health measures, can provide an invaluable tool to achieve lasting control, leading to schistosomiasis elimination. Australia has played a leading role in schistosomiasis vaccine research over many years and this review presents an overview of some of the significant contributions made by Australian scientists in this important area. MDPI 2021-08-06 /pmc/articles/PMC8402410/ /pubmed/34451997 http://dx.doi.org/10.3390/vaccines9080872 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review McManus, Donald P. The Search for a Schistosomiasis Vaccine: Australia’s Contribution |
title | The Search for a Schistosomiasis Vaccine: Australia’s Contribution |
title_full | The Search for a Schistosomiasis Vaccine: Australia’s Contribution |
title_fullStr | The Search for a Schistosomiasis Vaccine: Australia’s Contribution |
title_full_unstemmed | The Search for a Schistosomiasis Vaccine: Australia’s Contribution |
title_short | The Search for a Schistosomiasis Vaccine: Australia’s Contribution |
title_sort | search for a schistosomiasis vaccine: australia’s contribution |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402410/ https://www.ncbi.nlm.nih.gov/pubmed/34451997 http://dx.doi.org/10.3390/vaccines9080872 |
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