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The Search for a Schistosomiasis Vaccine: Australia’s Contribution

Schistosomiasis, a neglected tropical disease caused by parasitic flatworms of the genus Schistosoma, results in considerable human morbidity in sub-Saharan Africa, in particular, but also parts of the Middle East, South America, and Southeast Asia. The anti-schistosome drug praziquantel is efficaci...

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Detalles Bibliográficos
Autor principal: McManus, Donald P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402410/
https://www.ncbi.nlm.nih.gov/pubmed/34451997
http://dx.doi.org/10.3390/vaccines9080872
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author McManus, Donald P.
author_facet McManus, Donald P.
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description Schistosomiasis, a neglected tropical disease caused by parasitic flatworms of the genus Schistosoma, results in considerable human morbidity in sub-Saharan Africa, in particular, but also parts of the Middle East, South America, and Southeast Asia. The anti-schistosome drug praziquantel is efficacious and safe against the adult parasites of all Schistosoma species infecting humans; however, it does not prevent reinfection and the development of drug resistance is a constant concern. The need to develop an effective vaccine is of great importance if the health of many in the developing world is to be improved. Indeed, vaccination, in combination with other public health measures, can provide an invaluable tool to achieve lasting control, leading to schistosomiasis elimination. Australia has played a leading role in schistosomiasis vaccine research over many years and this review presents an overview of some of the significant contributions made by Australian scientists in this important area.
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spelling pubmed-84024102021-08-29 The Search for a Schistosomiasis Vaccine: Australia’s Contribution McManus, Donald P. Vaccines (Basel) Review Schistosomiasis, a neglected tropical disease caused by parasitic flatworms of the genus Schistosoma, results in considerable human morbidity in sub-Saharan Africa, in particular, but also parts of the Middle East, South America, and Southeast Asia. The anti-schistosome drug praziquantel is efficacious and safe against the adult parasites of all Schistosoma species infecting humans; however, it does not prevent reinfection and the development of drug resistance is a constant concern. The need to develop an effective vaccine is of great importance if the health of many in the developing world is to be improved. Indeed, vaccination, in combination with other public health measures, can provide an invaluable tool to achieve lasting control, leading to schistosomiasis elimination. Australia has played a leading role in schistosomiasis vaccine research over many years and this review presents an overview of some of the significant contributions made by Australian scientists in this important area. MDPI 2021-08-06 /pmc/articles/PMC8402410/ /pubmed/34451997 http://dx.doi.org/10.3390/vaccines9080872 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
McManus, Donald P.
The Search for a Schistosomiasis Vaccine: Australia’s Contribution
title The Search for a Schistosomiasis Vaccine: Australia’s Contribution
title_full The Search for a Schistosomiasis Vaccine: Australia’s Contribution
title_fullStr The Search for a Schistosomiasis Vaccine: Australia’s Contribution
title_full_unstemmed The Search for a Schistosomiasis Vaccine: Australia’s Contribution
title_short The Search for a Schistosomiasis Vaccine: Australia’s Contribution
title_sort search for a schistosomiasis vaccine: australia’s contribution
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402410/
https://www.ncbi.nlm.nih.gov/pubmed/34451997
http://dx.doi.org/10.3390/vaccines9080872
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