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Effects of Heavy Isotopes ((2)H(1) and (18)O(16)) Depleted Water Con-Sumption on Physical Recovery and Metabolic and Immunological Parameters of Healthy Volunteers under Regular Fitness Load
Water depleted of heavy isotopes, such as (2)H(1) and (18)O(16) (HIDW), has shown numerous biological/health effects in vitro, in vivo, and in epidemiological studies. Major observations were related to cell growth/differentiation, immune/nervous system responses, endurance/adaptation, mitochondrial...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402423/ https://www.ncbi.nlm.nih.gov/pubmed/34437371 http://dx.doi.org/10.3390/sports9080110 |
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author | Kharaeva, Zaira Hokonova, Tamara Elmurzaeva, Jannet Dzamihova, Irlana Mayer, Wolfgang De Luca, Chiara Trakhtman, Ilya Korkina, Liudmila |
author_facet | Kharaeva, Zaira Hokonova, Tamara Elmurzaeva, Jannet Dzamihova, Irlana Mayer, Wolfgang De Luca, Chiara Trakhtman, Ilya Korkina, Liudmila |
author_sort | Kharaeva, Zaira |
collection | PubMed |
description | Water depleted of heavy isotopes, such as (2)H(1) and (18)O(16) (HIDW), has shown numerous biological/health effects in vitro, in vivo, and in epidemiological studies. Major observations were related to cell growth/differentiation, immune/nervous system responses, endurance/adaptation, mitochondrial electron transfer, energy production, glucose metabolism, etc. No human studies to confirm physiological, metabolic, and immune responses to the consumption of HIDW have been performed. A placebo-controlled study on healthy volunteers (n = 50) under fitness load who consumed 1.5 L HIDW (58 ppm (2)H and 1780 ppm (18)O) or normal water for 60 days was carried out. Plasma content of (2)H(1) and (18)O(16), markers of energy, lipid, and glucose metabolism, anthropometric, cardio-vascular, oxidant/antioxidant, and immunological parameters were determined. Significant decrease in plasma heavy isotopes in the group consuming HIDW was observed in concomitance with an increase in ATP, insulin, and LDH, and diminished plasma lactate. Several anthropometric and cardio-vascular parameters were improved as compared to placebo group. Lipid markers demonstrated antiatherogenic effects, while oxidant/antioxidant parameters revealed HIDW-induced hormesis. Antibacterial/antiviral immunity was remarkably higher in HIDW versus placebo group. Conclusions: HIDW consumption by humans under fitness load could be a valid approach to improve their adaptation/recovery through several mechanisms. |
format | Online Article Text |
id | pubmed-8402423 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84024232021-08-29 Effects of Heavy Isotopes ((2)H(1) and (18)O(16)) Depleted Water Con-Sumption on Physical Recovery and Metabolic and Immunological Parameters of Healthy Volunteers under Regular Fitness Load Kharaeva, Zaira Hokonova, Tamara Elmurzaeva, Jannet Dzamihova, Irlana Mayer, Wolfgang De Luca, Chiara Trakhtman, Ilya Korkina, Liudmila Sports (Basel) Article Water depleted of heavy isotopes, such as (2)H(1) and (18)O(16) (HIDW), has shown numerous biological/health effects in vitro, in vivo, and in epidemiological studies. Major observations were related to cell growth/differentiation, immune/nervous system responses, endurance/adaptation, mitochondrial electron transfer, energy production, glucose metabolism, etc. No human studies to confirm physiological, metabolic, and immune responses to the consumption of HIDW have been performed. A placebo-controlled study on healthy volunteers (n = 50) under fitness load who consumed 1.5 L HIDW (58 ppm (2)H and 1780 ppm (18)O) or normal water for 60 days was carried out. Plasma content of (2)H(1) and (18)O(16), markers of energy, lipid, and glucose metabolism, anthropometric, cardio-vascular, oxidant/antioxidant, and immunological parameters were determined. Significant decrease in plasma heavy isotopes in the group consuming HIDW was observed in concomitance with an increase in ATP, insulin, and LDH, and diminished plasma lactate. Several anthropometric and cardio-vascular parameters were improved as compared to placebo group. Lipid markers demonstrated antiatherogenic effects, while oxidant/antioxidant parameters revealed HIDW-induced hormesis. Antibacterial/antiviral immunity was remarkably higher in HIDW versus placebo group. Conclusions: HIDW consumption by humans under fitness load could be a valid approach to improve their adaptation/recovery through several mechanisms. MDPI 2021-08-11 /pmc/articles/PMC8402423/ /pubmed/34437371 http://dx.doi.org/10.3390/sports9080110 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kharaeva, Zaira Hokonova, Tamara Elmurzaeva, Jannet Dzamihova, Irlana Mayer, Wolfgang De Luca, Chiara Trakhtman, Ilya Korkina, Liudmila Effects of Heavy Isotopes ((2)H(1) and (18)O(16)) Depleted Water Con-Sumption on Physical Recovery and Metabolic and Immunological Parameters of Healthy Volunteers under Regular Fitness Load |
title | Effects of Heavy Isotopes ((2)H(1) and (18)O(16)) Depleted Water Con-Sumption on Physical Recovery and Metabolic and Immunological Parameters of Healthy Volunteers under Regular Fitness Load |
title_full | Effects of Heavy Isotopes ((2)H(1) and (18)O(16)) Depleted Water Con-Sumption on Physical Recovery and Metabolic and Immunological Parameters of Healthy Volunteers under Regular Fitness Load |
title_fullStr | Effects of Heavy Isotopes ((2)H(1) and (18)O(16)) Depleted Water Con-Sumption on Physical Recovery and Metabolic and Immunological Parameters of Healthy Volunteers under Regular Fitness Load |
title_full_unstemmed | Effects of Heavy Isotopes ((2)H(1) and (18)O(16)) Depleted Water Con-Sumption on Physical Recovery and Metabolic and Immunological Parameters of Healthy Volunteers under Regular Fitness Load |
title_short | Effects of Heavy Isotopes ((2)H(1) and (18)O(16)) Depleted Water Con-Sumption on Physical Recovery and Metabolic and Immunological Parameters of Healthy Volunteers under Regular Fitness Load |
title_sort | effects of heavy isotopes ((2)h(1) and (18)o(16)) depleted water con-sumption on physical recovery and metabolic and immunological parameters of healthy volunteers under regular fitness load |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402423/ https://www.ncbi.nlm.nih.gov/pubmed/34437371 http://dx.doi.org/10.3390/sports9080110 |
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