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HPV Vaccination in Women Treated for Cervical Intraepithelial Neoplasia: A Budget Impact Analysis

Human Papillomavirus (HPV) is the most common sexually transmitted infection. Its progression is related to the development of malignant lesions, particularly cervical intraepithelial neoplasias (CINs). CINs correlate with a higher risk of premature births, and their excisional and ablative treatmen...

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Autores principales: Basile, Michele, Calabrò, Giovanna Elisa, Ghelardi, Alessandro, Ricciardi, Roberto, De Vincenzo, Rosa, Cicchetti, Americo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402448/
https://www.ncbi.nlm.nih.gov/pubmed/34451941
http://dx.doi.org/10.3390/vaccines9080816
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author Basile, Michele
Calabrò, Giovanna Elisa
Ghelardi, Alessandro
Ricciardi, Roberto
De Vincenzo, Rosa
Cicchetti, Americo
author_facet Basile, Michele
Calabrò, Giovanna Elisa
Ghelardi, Alessandro
Ricciardi, Roberto
De Vincenzo, Rosa
Cicchetti, Americo
author_sort Basile, Michele
collection PubMed
description Human Papillomavirus (HPV) is the most common sexually transmitted infection. Its progression is related to the development of malignant lesions, particularly cervical intraepithelial neoplasias (CINs). CINs correlate with a higher risk of premature births, and their excisional and ablative treatment further increases this risk in pregnant women. These complications are also correlated with higher healthcare costs for their management. In Italy, more than 26,000 new cases of CINs are estimated to occur yearly and their economic burden is significant. Therefore, the management of these conditions is a public health priority. Since HPV vaccination is associated with a reduced risk of relapse in women surgically treated for HPV-related injuries, we estimated the economic impact of extending HPV vaccination to this target population. This strategy would result in a significant reduction in the general costs of managing these women, resulting in an overall saving for the Italian Health Service of €155,596.38 in 5 years. This lower cost is due not only to the reduced incidence of CINs following vaccination, but also to the lower occurrence of preterm births. Extending HPV vaccination to this target population as part of a care path to be offered to women treated for HPV injuries is therefore desirable.
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spelling pubmed-84024482021-08-29 HPV Vaccination in Women Treated for Cervical Intraepithelial Neoplasia: A Budget Impact Analysis Basile, Michele Calabrò, Giovanna Elisa Ghelardi, Alessandro Ricciardi, Roberto De Vincenzo, Rosa Cicchetti, Americo Vaccines (Basel) Article Human Papillomavirus (HPV) is the most common sexually transmitted infection. Its progression is related to the development of malignant lesions, particularly cervical intraepithelial neoplasias (CINs). CINs correlate with a higher risk of premature births, and their excisional and ablative treatment further increases this risk in pregnant women. These complications are also correlated with higher healthcare costs for their management. In Italy, more than 26,000 new cases of CINs are estimated to occur yearly and their economic burden is significant. Therefore, the management of these conditions is a public health priority. Since HPV vaccination is associated with a reduced risk of relapse in women surgically treated for HPV-related injuries, we estimated the economic impact of extending HPV vaccination to this target population. This strategy would result in a significant reduction in the general costs of managing these women, resulting in an overall saving for the Italian Health Service of €155,596.38 in 5 years. This lower cost is due not only to the reduced incidence of CINs following vaccination, but also to the lower occurrence of preterm births. Extending HPV vaccination to this target population as part of a care path to be offered to women treated for HPV injuries is therefore desirable. MDPI 2021-07-22 /pmc/articles/PMC8402448/ /pubmed/34451941 http://dx.doi.org/10.3390/vaccines9080816 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Basile, Michele
Calabrò, Giovanna Elisa
Ghelardi, Alessandro
Ricciardi, Roberto
De Vincenzo, Rosa
Cicchetti, Americo
HPV Vaccination in Women Treated for Cervical Intraepithelial Neoplasia: A Budget Impact Analysis
title HPV Vaccination in Women Treated for Cervical Intraepithelial Neoplasia: A Budget Impact Analysis
title_full HPV Vaccination in Women Treated for Cervical Intraepithelial Neoplasia: A Budget Impact Analysis
title_fullStr HPV Vaccination in Women Treated for Cervical Intraepithelial Neoplasia: A Budget Impact Analysis
title_full_unstemmed HPV Vaccination in Women Treated for Cervical Intraepithelial Neoplasia: A Budget Impact Analysis
title_short HPV Vaccination in Women Treated for Cervical Intraepithelial Neoplasia: A Budget Impact Analysis
title_sort hpv vaccination in women treated for cervical intraepithelial neoplasia: a budget impact analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402448/
https://www.ncbi.nlm.nih.gov/pubmed/34451941
http://dx.doi.org/10.3390/vaccines9080816
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